Tapahtumakalenteri
Dissertation: Julia Niskanen
Opponent: professor Johanna Schleutker, University of Turku
Dissertation: Jenni Liikanen
Opponent: Professor Gábor Cserni, University of Szeged
Dissertation: Paavo Häppölä
Opponent: Docent Patrik Magnusson, Karolinska Institutet
HiLIFE Webinar/ Biomedicum Helsinki seminar: Julia TCW
Dr. Julia TCW is an assistant professor at Boston University (primary appointment at Department of Pharmacology & Experimental therapeutics) and a director of the Laboratory of Human Induced Pluripotent Stem Cell Therapeutics. She received Ph.D. and A.M. in Molecular and Cellular Biology from Harvard University with Biophysics training background and research studies in induced pluripotent stem cell (iPSC) reprogramming in the Department of Stem Cell and Regenerative Biology. She then perused her postdoctoral research in the Department of Neuroscience, Ronald M. Loeb Center for Alzheimer’s Disease, Department of Genetics and Genomic Sciences at Icahn School of Medicine at Mount Sinai, New York, with a research focus of the development of iPSC models and study Alzheimer’s disease (AD) genetics. Currently, the TCW laboratory is aiming at human induced pluripotent stem cell therapeutics for AD and neurodegenerative diseases.
Welcome to this exciting seminar!
Selected publications:
TCW J#, Qian L, Pipalia NH, Chao MJ, Liang SA, Shi Y, Jain B.R., Bertelsen SE, Kapoor M, Marcora E, Sikora E, Andrews EJ, Martini AC, Karch, CM, Head E, Holtzman DM, Zhang B, Wang M, Maxfield FR, Poon WW, Goate AM. Cholesterol and matrisome pathways dysregulated in astrocytes and microglia. Cell, Jun, 2022. https://www.cell.com/cell/pdf/S0092-8674(22)00648-1.pdf
TCW J*, Preman P*, Snellinx A, Calafate S, Alfonso-Triguero M, Corthout N, Munck S, Rudolf Thal D, Goate AM, De Strooper B, Arranz AM. Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-β plaques. Molecular Neurodegeneration. 2021;16:68. *Co-first authors PMID: 34563212 PMCID: PMC8467145. https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-021-00487-8
Saroja SR, Gorbachev K, TCW J, Goate AM, Pereira AC. Astrocyte-secreted glypican-4 drives APOE4-dependent tau hyperphosphorylation. PNAS, Jul, 2022. https://www.pnas.org/doi/10.1073/pnas.2108870119
Dissertation: Risto Halonen
Sleep and its oscillatory characteristics in overnight learning - what is the role of plasticity genes BDNF and COMT?