Tapahtumakalenteri

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HiLIFE / Biomedicum Helsinki seminar by Bogdan Pasaniuc:

Polygenic risk scores for precision medicine: promises and challenges

Dr Pasaniuc is an professor of Computational Medicine, Human Genetics and Pathology & Laboratory Medicine at UCLA. Dr Pasaniuc develops statistical and computational methods to understand the genetic basis of disease, focusing on under-represented populations, integrative genomics, and biobank studies. Dr Pasaniuc group developed machine learning methods to integrate epigenetic profiles within trans-ancestry studies to localize disease variants and genes; his group introduced transcriptome-wide association studies (TWAS) using predicted gene expression as a principled approach to identify disease genes for many traits such as Schizophrenia, Ovarian Cancer and Prostate Cancer. Dr Pasaniuc serves as Associate Director of Population Genetics of the Institute for Precision Health at UCLA that links the genetics of more than 150k patients with their electronic health record to predict health outcomes, to stratify patients based on their genetic risk to disease and to translate genomics to the clinic. Dr Pasaniuc also serves as PI for the Center for Admixed populations and Health Equity and for the Biomedical Data Science Training Program for Precision Health Equity at UCLA.

 

Bogdan Lab

 

Welcome to this exciting seminar!

Andrea Ganna


Selected publications

Polygenic scoring accuracy varies across the genetic ancestry continuum. Ding et al. Nature. 2023.

Large uncertainty in individual polygenic risk score estimation impacts PRS-based risk stratification. Ding*, Hou*, et al. Nat Genet. 2022.

Impact of cross-ancestry genetic architecture on GWASs in admixed populations. Mester et al. AJHG. 2023.

Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals. Hou et al. Nat Genet. 2023.


Aloitusaika: 14.10.2024 13:00
Lopetusaika: 14.10.2024 14:00
Kesto: 1 hour
Sijainti: Biomedicum1, lecture hall 1, Haartmaninkatu 8, 00290 Helsinki
Tyyppi: Seminar
Organisaatio: Helsinki Institute of Life Science HiLIFE
Yhteyshenkilö: hilife-seminars@helsinki.fi
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Special semnar by Prof Gyorgy Hajnóczky

Gyorgy Hajnóczky: Mitochondrial form and function in the brain

Prof Gyorgy Hajnóczky from the Department of Pathology and Cell Biology, Thomas Jefferson University, Philadelphia, is the Founding Director of the MitoCare Center for Mitochondrial Imaging Research and Diagnostics. Hajnóczky group was among the first to visualize mitochondrial energy and ion metabolism in single live cells. They are credited with the discovery of physically tethered contact sites between endoplasmic reticulum (ER) and mitochondria, and that the ER-mitochondrial “synapses” enable calcium signal propagation to the mitochondria to control both energy production and cell death. They have also had major contributions to the current understanding of mitochondrial maintenance and proper distribution by fusion and movement. Hajnóczky group has invented numerous microscopy techniques and probes to benefit the field. Their major current focus is on the role of dysregulation of mitochondrial calcium homeostasis, energetics and dynamics in human neuropathogenesis.

 

 

For a meeting with Prof Hajnóczky, please contact henna.tyynismaa@helsinki.fi.

 

EXAMPLES OF RECENT PUBLICATIONS:

 

MSTO1 is a cytoplasmic pro-mitochondrial fusion protein, whose mutation induces myopathy and ataxia in humans.

Gal A, Balicza P, Weaver D, Naghdi S, Joseph SK, Várnai P, Gyuris T, Horváth A, Nagy L, Seifert EL, Molnar MJ, Hajnóczky G. EMBO Mol Med. 2023 Aug 7;15(8):e17911. doi: 10.15252/emmm.202317911.

 

MICU1 controls the sensitivity of the mitochondrial Ca2+ uniporter to activators and inhibitors.

Rodríguez-Prados M, Huang KT, Márta K, Paillard M, Csordás G, Joseph SK, Hajnóczky G. Cell Chem Biol. 2023 Jun 15;30(6):606-617.e4. doi: 10.1016/j.chembiol.2023.05.002.

 

Fuel oxidation under the control of mitochondrial shape and dynamics.

Seifert EL, Hajnóczky G. EMBO J. 2023 Jun 1;42(11):e114129. doi: 10.15252/embj.2023114129.

 

Capture at the ER-mitochondrial contacts licenses IP3 receptors to stimulate local Ca2+ transfer and oxidative metabolism.

Katona M, Bartók Á, Nichtova Z, Csordás G, Berezhnaya E, Weaver D, Ghosh A, Várnai P, Yule DI, Hajnóczky G. Nat Commun. 2022 Nov 9;13(1):6779. doi: 10.1038/s41467-022-34365-8.

 

Uncontrolled mitochondrial calcium uptake underlies the pathogenesis of neurodegeneration in MICU1-deficient mice and patients.

Singh R, Bartok A, Paillard M, Tyburski A, Elliott M, Hajnóczky G. Sci Adv. 2022 Mar 18;8(11):eabj4716. doi: 10.1126/sciadv.abj4716.

 

Oxidative bursts of single mitochondria mediate retrograde signaling toward the ER.

Booth DM, Várnai P, Joseph SK, Hajnóczky G. Mol Cell. 2021 Sep 16;81(18):3866-3876.e2. doi: 10.1016/j.molcel.2021.07.014.

 

IP3 receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer.

Bartok A, Weaver D, Golenár T, Nichtova Z, Katona M, Bánsághi S, Alzayady KJ, Thomas VK, Ando H, Mikoshiba K, Joseph SK, Yule DI, Csordás G, Hajnóczky G. Nat Commun. 2019 Aug 19;10(1):3726. doi: 10.1038/s41467-019-11646-3.

 


 

Best regards,

Henna Tyynismaa & Emil Ylikallio



Aloitusaika: 14.10.2024 15:00
Lopetusaika: 14.10.2024 16:00
Kesto:
Sijainti: Biomedicum 1, seminar room 1-2
Tyyppi: Seminar
Organisaatio: UH, Faculty of Medicine
Yhteyshenkilö: henna.tyynismaa@helsinki.fi
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Dissertation: Julius Rönkkö

Julius Rönkkö, University of Helsinki, Faculty of Medicine, Doctoral Programme in Biomedicine
Charcot-Marie-Tooth disease type 1J

Opponent: Professor Gyorgy Hajnozcky, Thomas Jefferson University, US



Aloitusaika: 15.10.2024 13:00
Lopetusaika: 15.10.2024 15:00
Kesto: 2 hours
Sijainti: Biomedicum1, lecture hall 1, Haartmaninkatu 8, 00290 Helsinki
Tyyppi: Dissertation
Organisaatio: UH, Faculty of Medicine
Yhteyshenkilö: julius.ronkko@helsinki.fi
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Dissertation: Jannica Björklöf

Jannica Björklöf, University of Helsinki, Faculty of Medicine, Doctoral Program in Population Health
Peripheral and central insulin regulation and links to physical and mental phenotypes of aging

Opponent: Professor Tiina Laatikainen, University of Eastern Finland



Aloitusaika: 18.10.2024 12:00
Lopetusaika: 18.10.2024 14:00
Kesto: 2 hours
Sijainti: UH main building, Tekla Hultin sali (F3003), Unioninkatu 34
Tyyppi: Dissertation
Organisaatio: UH, Faculty of Medicine
Yhteyshenkilö: jannica.bjorklof@helsinki.fi
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Dissertation: Leena Raudasoja

Leena Raudasoja, University of Helsinki, Faculty of Medicine
Fracture of the distal radius : Epidemiology and treatment in Finland

Opponent: orto trauma docent Antti Launonen, University of Tampere



Aloitusaika: 18.10.2024 12:00
Lopetusaika: 18.10.2024 14:00
Kesto: 2 hours
Sijainti: HUS SIltasairaala, Töölö luentosali STB3.03, Haartmaninkatu 4
Tyyppi: Dissertation
Organisaatio: UH, Faculty of Medicine
Yhteyshenkilö: leena.raudasoja@helsinki.fi