lokakuu 03

Special Seminar Dr. Kathleen J Green

Linking Epidermal Morphogenesis and the Immune Barrier through Desmosomes
Dr. Green is the Joseph L. Mayberry Professor of Pathology at Northwestern University and Professor in the Department of Dermatology.  She serves as Associate Director for Basic Sciences in the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois. She received her Ph.D. in Cell and Developmental Biology from Washington University in St. Louis and carried out Postdoctoral Training in the Department of Cell Biology at Northwestern University, where she joined the faculty in 1987.
Dr. Green's research focuses on how cadherins and their associated proteins direct tissue morphogenesis and differentiation. Her pioneering work on intercellular junctions called desmosomes contributed to the discovery of their involvement in diseases of the skin and heart. The lab is currently determining how keratinocyte cadherins that appeared late in evolution integrate mechanical and chemical signaling pathways to direct formation of complex tissues through both cell autonomous and paracrine signaling.  Dr. Green served as Secretary for the American Society for Cell Biology and is past President of the Society for Investigative Dermatology. An Honorary Member of the Society for Investigative Dermatology and European Society for Dermatological Research, Dr. Green was elected into the German National Academy of Sciences in 2016.

Relevant References:
a. Nekrasova, O., R.M. Harmon, J.A. Broussard, J.L. Koetsier, L.M. Godsel, G.N. Fitz, M. Gardel and K.J. Green.  (2018). Desmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination. Nat. Commun. 9 (1): 1053. Doi: 10.1038/s41467-018-03414-6. PMC5849617.
b. Broussard, J.A., J.L. Koetsier, M. Hegazy and K.J. Green.  (2021). Desmosomes polarize and integrate chemical and mechanical signaling to govern epidermal tissue form and function.  Curr. Biol. 31: 3275-91. PMC8355090.
c. Godsel, L.M.*, Q.R. Roth-Carter*, J.L. Koetsier, L.C. Tsoi, J.A. Broussard, G.N. Fitz, S.M. Lloyd, J. Kweon, A.L. Huffine, H.E. Burks, M. Hegazy, S. Amagai, P.W. Harms, J.L. Johnson, G. Urciuli, L.T. Doglio, W.R. Swindell, R. Awatramani, E. Sprecher, X. Bao, E. Cohen-Barak, C. Missero, J.E. Gudjonsson and K.J. Green. (2022). Translational implications of Th17-skewed inflammation due to genetic deficiency of a cadherin stress sensor. J. Clin. Invest. 1132: e144363. PMC8803337.
d. Hegazy M, J.L. Koetsier, A.L. Huffine, J.A. Broussard, B.M. Godsel, L.M. Godsel*, K.J. Green*. Epidermal stratification requires retromer-mediated Desmoglein-1 recycling. (2021). BioRxiv. 2021.10.25.464989. 10.1101/2021.10.25.464989. *Co-corresponding authors.  
e. REVIEW:   Hegazy, M., A.L. Perl, S.A. Svoboda, K.J. Green (2022). Desmosomal cadherins in health and disease. Ann. Rev. Pathol. 17: 47-72. DOI: 10.1146/annurev-pathol-042320-092912. PMC87992335.

Aloitusaika: 03.10.2022 12:00
Lopetusaika: 03.10.2022 13:00
Sijainti: Biomedicum1, lecture hall 3, Haartmaninkatu 8, 00290 Helsinki
Tyyppi: Seminar
Organisaatio: UH, Faculty of Medicine
Yhteyshenkilö: sara.wickstrom@helsinki.fi
lokakuu 03

HiLIFE webinar/Biomedicum Helsinki seminar: Silvia Cappello

​Extracellular Signaling in Neurodevelopmental Disorders

Silvia Cappello is a research group leader at the Max Planck Institute of Psychiatry. The major focus of her laboratory is to understand the basic molecular and cellular mechanisms regulating the development of the human brain. Silvia Cappello studied biotechnology at the University of Bologna, Italy, and carried out her Ph.D. at the University of Padua, Italy and in the laboratory of Magdalena Götz, at the Helmholtz Center. As a postdoctoral fellow, she studied mechanisms regulating neurogenesis and neuronal migration with Magdalena Götz and in the laboratory of Richard Vallee at Columbia University.  

Cappello Research Group 

Welcome to this exciting seminar!  

Takashi Namba 


Selected publications: 

Christina Kyrousi, Adam C. O’Neill, Agnieska Brazovskaja, Laure Coquand, Rossella Di Giaimo, Isabel Y. Buchsbaum, Renzo Guerrini, Frances Elmslie, Alexandre Baffet, Barbara Treutlein, Stephen P. Robertson and Silvia Cappello. The extracellular matrix protein LGALS3BP regulates progenitor position and relates to human cortical complexity. Nature Communications, 2021, 12, 6298. 

Francesco Di Matteo*, Fabrizia Pipicelli*, Christina Kyrousi, Isabella Tovecci, Eduardo Penna, Marianna Crispino, Angela Chambery, Rosita Russo, Ane Cristina Ayo-Martin, Martina Giordano, Anke Hoffmann, Emilio Ciusani, Laura Canafoglia, Magdalena Gotz, Rossella Di Giaimo# and Silvia Cappello#. Cystatin B is essential for proliferation and interneuron migration in individuals with EPM1 epilepsy. EMBO Molecular Medicine, 2020, 12(6):e11419.  

Isabel Y. Buchsbaum, Pavel Kielkowski, Grazia Giorgio, Adam C. O’Neill, Rossella Di Giaimo, Christina Kyrousi, Shahryar Khattak, Stephan A. Sieber, Stephen P. Robertson and Silvia Cappello. ECE2 regulates Neurogenesis and Neuronal Migration during Human Cortical Development. EMBO Reports, 2020, 21(5):e48204. 

Johannes Klaus*, Sabina Kanton*, Christina Kyrousi*, Ane C. Ayo-Martin, Rossella Di Giaimo, Stephan Riesenberg, Adam C. O’Neill, J. Gray Camp, Chiara Tocco, Malgorzata Santel, Ejona Rusha, Micha Drukker, Mariana Schroeder, Magdalena Götz, Stephen P. Robertson, Barbara Treutlein# and Silvia Cappello#. Altered neuronal migratory trajectories in human cerebral organoids derived from individuals with neuronal heterotopia. Nature Medicine 2019, 25(4):561-568. 



University of Helsinki students please note: If you wish to obtain credits (DPBM, ILS)  from this webinar series, please rename yourself in Zoom with first name + last name (do not use nickname/user ID/student number/just first name). 

Aloitusaika: 03.10.2022 13:00
Lopetusaika: 03.10.2022 14:00
Kesto: 1 hour
Sijainti: Biomedicum1, lecture hall 2, Haartmaninkatu 8, 00290 Helsinki
Tyyppi: Seminar
Organisaatio: Biomedicum Helsinki
Yhteyshenkilö: hilife-seminars@helsinki.fi
lokakuu 05

Single Cell Transcriptomics Symposium (DPBM-161)


Martin Enge (Karolinska Institutet), Laura Elo (Univ. of Turku), Naveed Ishaque (Charité – Universitätsmedizin Berlin), Kim Thrane (KTH Royal Institute of Technology), Andrew Erickson (UH), Biswajyoti Sahu (Univ. of Oslo & UH), Akira Takeda (Univ. of Turku), Eliisa Kekäläinen (UH) and Caroline Heckman (FIMM).

Aloitusaika: 05.10.2022 09:00
Lopetusaika: 05.10.2022 17:00
Kesto: 8 hours
Sijainti: Biomedicum1, lecture hall 2, Haartmaninkatu 8, 00290 Helsinki
Tyyppi: Symposium
Organisaatio: UH, Faculty of Medicine
Yhteyshenkilö: anna.vaharautio@helsinki.fi
lokakuu 07

Dissertation: Valentina Kieseppä

​Valentina Kieseppä, University o, f Helsinki, Faculty of Medicine, Doctoral Program in Population Health
Mental health service use among immigrants living in Finland

Opponent:  professor Jouko Miettunen, University of Oulu

Aloitusaika: 07.10.2022 12:00
Lopetusaika: 07.10.2022 14:00
Kesto: 2 hours
Sijainti: Siltavuorenpenger 3A, Athena hall
Tyyppi: Dissertation
Organisaatio: UH, Faculty of Medicine
Yhteyshenkilö: https://helda.helsinki.fi/handle/10138/347357
lokakuu 07

Dissertation: Sanni Ruotsalainen

​Sanni Ruotsalainen, University of Helsinki, Faculty of Medicine, Doctoral Program in Population Health
Novel genetic risk factors in coronary artery disease and related biomarkers

Opponent: professor Janne Pitkäniemi, Suomen Syöpärekisteri

Aloitusaika: 07.10.2022 12:00
Lopetusaika: 07.10.2022 14:00
Kesto: 2 hours
Sijainti: Biomedicum1, lecture hall 3, Haartmaninkatu 8, 00290 Helsinki
Tyyppi: Dissertation
Organisaatio: UH, Faculty of Medicine
Yhteyshenkilö: sanni.ruotsalainen@helsinki.fi