Tapahtumakalenteri
Kliinisen kemian seminaari: dosenttiluento
Tuukka Helin: Hyytymisen analytiikan perusteet
Kohderyhmä on lääketieteen perustutkinto-opiskelijat
Dosentuurin ala on kliininen kemia
Biostatistics drop-in workshop
Are you a researcher needing support with any statistical aspect of your work? The Biostatistics Consulting Service here at Meilahti Campus holds drop-in workshop sessions every other week to answer smaller questions about your analysis - solving a particular problem, how to get started, etc. We provide service in Finnish, English and Swedish.
The next workshop is on Wednesday 16th April, at 13:00-15:00 in Biomedicum 2B, in the Olohuone on floor 6. Come whenever you can. Note that you may end up waiting a while for your turn, especially early on in the session. We aim to spend no more than 15 minutes with each customer.
Bring:
- your computer
- your data
- your questions
and we biostatisticians will be on hand to help and guide.
Registration is not required, but you can help us prepare for your questions by filling in this form. The workshops are open to any researcher at the university's Medical Faculty, HUS or FIMM.
The following sessions are planned for 30th April, 14th May and 28th May.
For more in-depth questions, please book a one-on-one consultation session using this e-form where we will have time to go into more detail.
From the Biostatistics Team
FICAN Science webinar by prof Aki Manninen
Aki Manninen, Professor of Cell Biology, Leader of the Disease Networks Research Unit, Faculty of Biochemistry and Molecular Medicine, University of Oulu
This webinar is organized by FICAN North (Pohjoinen syöpäkeskus). The webinar will be held online in Teams (link below) and is open to everyone interested in cancer research.
SleepWell Special Seminar by Professor Michael Lazarus
Michael Lazarus received his doctoral degree (Dr. rer. nat.) in biochemistry at the University of Würzburg in Germany. In 1999, he joined Prof. Osamu Hayaishi’s group at the Osaka Bioscience Institute with prestigious fellowships from the Takeda Science Foundation of Japan and the Alexander-von-Humboldt Foundation of Germany. He then moved to Harvard Medical School, where, from 2002 to 2007, he was an Instructor in Prof. Clifford Saper’s Systems Neurobiology group to examine the differential role of prostaglandin E2 receptors in the regulation of fever by establishing transgenic mouse models with conditional expression of each receptor. In 2007, he returned to the Osaka Bioscience Institute, where he was a Research Associate (equivalent to the rank of assistant professor) and led a sleep research group in the Department of Molecular Behavioral Biology between 2007 and 2013. Dr. Lazarus has been a Principal Investigator at the International Institute for Integrative Sleep Medicine (WPI-IIIS) since 2013 and a Professor at the Institute of Medicine of the University of Tsukuba since 2022. The investigative focus of the Lazarus Lab is the cellular and synaptic basis by which the brain regulates sleep and wakeful consciousness.
"Our experiments seek to link the activity of defined sets of neurons with neurobehavioral and electroencephalographic outcomes in behaving animals by using innovative genetically or chemically engineered systems (optogenetics, chemogenetics, or optopharmacology) in conjunction with in-vivo imaging. We also employ single-cell or spatial gene expression profiling to understand how sleep is regulated at cellular and molecular levels. Our pioneering work includes discovering that caffeine induces wakefulness by blocking adenosine receptors in the nucleus accumbens, a part of the brain associated with motivation, and identifying the brain circuit linking sleepiness and motivation."
Selected publications: *Corresponding author
- Roy K, Zhou Z, Otani R, …, *Wang Y, *Saitoh T, *Lazarus M. (2024) Optochemical control of slow-wave sleep in the nucleus accumbens of male mice by a photoactivatable allosteric modulator of adenosine A2A receptors. Nature Communications, 15, 3661 (SCI-IF: 16.6)
- Lin Y, Roy K, …, *Saitoh T, *Lazarus M (2023) Positive allosteric adenosine A2A receptor modulation suppresses insomnia associated with mania- and schizophrenia-like behaviors in mice, Frontiers in Pharmacology, 14:1138666 (SCI-IF: 5.988).
- Takata Y, Oishi Y, …, *Lazarus M. Sleep and wakefulness are controlled by ventral medial midbrain/pons GABAergic neurons in mice. Journal of Neuroscience, 38:10080, 2018 (SCI-IF: 6.7).
- Oishi Y, Xu Q, Wang L, …, *Huang ZL, *Lazarus M. Slow-wave sleep is controlled by a subset of nucleus accumbens core neurons in mice. Nature Communications, 8:734, 2017 (SCI-IF: 16.6).
- Oishi Y, Suzuki Y, Takahashi K, Yonezawa T, Kanda T, Takata Y, Cherasse Y, *Lazarus M. Activation of ventral tegmental area dopamine neurons produces wakefulness through dopamine D2–like receptors in mice. Brain Structure & Function, 222:2907-2915, 2017 (SCI-IF: 3.3).
- McEown K, Takata Y, Cherasse Y, Nagata N, Aritake K, *Lazarus M. Chemogenetic inhibition of the medial prefrontal cortex reverses the effects of REM sleep loss on sucrose consumption. eLife, 5:e20269, 2016 (SCI-IF: 8.1).
- Lazarus M, Huang Z-L, Lu J, Urade Y, *Chen J-F. How do the basal ganglia regulate sleep-wake behavior? Trends in Neuroscience, 35: 723-732, 2012 (SCI-IF: 14.5).
- Lazarus M, Shen HY, Cherasse Y, Qu WM, Huang ZL, Bass C, Winsky-Sommerer R, Semba K, Fredholm B, Boison D, Hayaishi O, *Urade Y, *Chen JF. Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens. Journal of Neuroscience, 31: 10067-10075, 2011 (SCI-IF: 6.2).
- Lazarus M, Yoshida K, Coppari R, Bass CE, Mochizuki T, Lowell BB, *Saper CB. EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses. Nature Neuroscience, 10:1131-3, 2007 (SCI-IF: 24.9).
Dissertation: Kristiina Kokkonen
Opponent: Professor emerita Kaija Holli, University of Tampere