Tapahtumakalenteri
Stem Cell Seminar
Arafath Najumudeen, Seyedehshima Naddafi
Spatially resolving the heterogeneity of intestinal epithelium in homeostasis and disease
Rubén Torregrosa Muñumer, Mitochondrial metabolism as a regulator of human stem cell identity
Credits for students, ILS-008
Please spread the word to your group members and others that might be interested.
Teaching Demonstrations of the Docentship Applicants
Docentship applicants give a demonstration of teaching skills as part of their application process. Demonstrations of teaching skills are open for all faculty members and students. Warmly welcome!
Program:
09:10-09:40 MD Kai Savonen (field of docentship: Public Health) aihe: Terveys, liikunta ja evoluutio; target group: terveystieteiden ammattilaiset/opiskelijat.
09:40-09:50 Tauko
09:50-10:20 PhD Anna Laury (field of docentship: Pathology) aihe: Endometrial Intraepithelial Neoplasia; target group: Pathology residents.
10:20-11:10 Tauko
11:10-11:40 MD Hanna Öhman (field of docentship: Geriatrics) aihe: Sairaaladeliriumin diagnostiikka ja hoidon perusteet; target group: Lääketieteen opiskelijat, 6. vuosi.
11:40-11:50 Tauko
11:50-12:20 MD Pauli Pöyhönen (field of docentship: Cardiology) aihe: Vasemman kammion diastolisen toiminnan arvio ultraäänellä; target group: Kardiologiaan erikoistuvat lääkärit.
Special seminar by Professor Kostas Tokatlidis
Welcome to a special seminar by Professor Kostas Tokatlidis, University of Glasgow.
Title: Oxidative-stress responsive protein import to the mitochondrial intermembrane space sustains healthy mitochondria
Prof Kostas Tokatlidis is the Chair of Biochemistry and Head of Mitochondrial Biology group at the University of Glasgow. He has been an EMBO member since 2013. His research interests are mitochondrial biogenesis and function and their impact on health and disease, focusing on proteins of the intermembrane space that undergo oxidative folding. They study the machinery, its molecular mechanism and structural basis and its relevance for redox homeostasis and cell physiology. Prof Tokatlidis has seminal discoveries of new mitochondrial protein import components, a new chaperone machinery, a novel redox-regulated import mechanism and responsive links to cellular stress.
Examples of recent publications of Prof Tokatlidis
Eaglesfield, R., Fernandez-Vizarra, E., Lacko, E., Caldwell, S. T. , Sloan, N. L., Siciarz, D., Hartley, R. C. and Tokatlidis, K. (2025) Sub-organellar mitochondrial hydrogen peroxide observed using a SNAP tag targeted coumarin-based fluorescent reporter. Redox Biology, 80, 103502. (doi: 10.1016/j.redox.2025.103502).
Dickson-Murray E, Nedara K, Modjtahedi N, Tokatlidis K. The Mia40/CHCHD4 Oxidative Folding System: Redox Regulation and Signaling in the Mitochondrial Intermembrane Space. Antioxidants (Basel). 2021 Apr 12;10(4):592. (doi: 10.3390/antiox10040592).
Webinar by Pedro Andrade: Models of seizures and epilepsy: Translational challenge
Webinar
organized by ILAE Young Epilepsy Section Finland
A warm welcome to a webinar on Thursday 24th of April 2025 at 17:00 in Teams.
Topic: Models of seizures and epilepsy: Translational challenge
Speaker: Pedro Andrade, University of Eastern Finland
Pedro Andrade works as a basic scientist in University of Eastern Finland specializing in acquisition and analysis (sleep, seizures etc) of rodent EEG. Additionally, he is a clinical neurophysiologist thus having expertise both in clinical and research EEG settings.
https://uefconnect.uef.fi/pedro.andrade-de-abreu/
The seminar is organized by the ILAE Young Epilepsy Section Finland.
The event is open to everyone interested. No preregistration is needed.
HiLIFE/Biomedicum Helsinki seminar by Professor Sergiu Pasca
Sergiu P. Pasca, M.D.
Don’t miss the chance to hear one of the most innovative neuroscientists of our time sharing how his lab is pushing the boundaries of biology and medicine!
- Discover how assembloids are revolutionising human brain modelling – bridging developmental biology and clinical medicine to unlock new insights into the human mind.
- Be inspired by Professor Pasca’s journey – from his unwavering pursuit to understand incurable brain disorders to developing next-generation therapeutics as leader of the transformative lab at Stanford University.
- Experience cutting-edge innovation – explore how assembloids technology is being used to build functional neural circuits and complex tissue systems, pushing the boundaries of biomedical science.
Remember to invite all your lab members, colleagues and students too, this is THE LECTURE to be at this spring 😍
✨Students: Join for the lecture lunch with Prof Pasca afterwards, info here: https://forms.gle/oL26JP2LEiYdDvm57
See you all there!
Teemu Aitta-aho, PI (teemu.aitta-aho@helsinki.fi)
Suvi Laitinen, student host (suvi.laitinen@helsinki.fi)
Cannot
wait to be there? Read more of his work: Lab
webpage https://www.pascalab.org/ For the last decade, Prof. Paşca and his team have made
highly interesting findings and created state-of-art assembloid method that has
wide relevance in the fields of neuroscience, medicine and developmental
biology. Most recently their determined effort for understanding
neuropsychiatric diseases yielded a next-generation therapeutic approach to
treat Timothy syndrome (type of genetic severe autism) (publ 1)💫 A few years back, Prof. Paşca and his team
very elegantly succeeded in creating a functional cortex-spinal cord-muscle
assembloid (publ 2) and in vivo implantation of those cortical assembloids
(publ 3). They also showed that cortical organoids maturation process matches
post-natal stages of human brain (publ 4)🤩 Paşca obtained his medical degree in 2007 from Hatieganu
School of Medicine, Romania and completed his post-doctoral studies in Stanford
University where he studies brain disorder genetics by developing hiPS neuron
models from patient skin samples. Currently, he is Kenneth T. Norris, Jr.
Professor of Psychiatry and Uytengsu Family Director of the Stanford Brain
Organogenesis Program at Stanford University. Selected
publications: Publ
1. Antisense oligonucleotide therapeutic approach for Timothy syndrome Xiaoyu
Chen, Fikri Birey, Min-Yin Li, Omer Revah, Rebecca Levy, Mayuri Vijay Thete,
Noah Reis, Konstantin Kaganovsky, Massimo Onesto, Noriaki Sakai, Zuzana
Hudacova, Jin Hao, Xiangling Meng, Seiji Nishino, John Huguenard, Sergiu P.
Pașca. Nature. 2024 Apr; 628(8009):818-825. doi:
10.1038/s41586-024-07310-6 Publ
2. Generation of Functional Human 3D Cortico-Motor Assembloids. Andersen
J, Revah O, Miura Y, Thom N, Amin ND, Kelley KW, Singh M, Chen X, Thete MV,
Walczak EM, Vogel H, Fan HC, Paşca SP. Cell. 2020 Dec
23;183(7):1913-1929.e26. doi: 10.1016/j.cell.2020.11.017. Publ
3. Maturation and circuit
integration of transplanted human cortical organoids. Omer Revah,
Felicity Gore, Kevin W. Kelley, Jimena Andersen, Noriaki Sakai, Xiaoyu Chen,
Min-Yin Li, Fikri Birey, Xiao Yang, Nay L. Saw, Samuel W. Baker, Neal D. Amin,
Shravanti Kulkarni, Rachana Mudipalli, Bianxiao Cui, Seiji Nishino, Gerald A.
Grant, Juliet K. Knowles, Mehrdad Shamloo, John R. Huguenard, Karl Deisseroth
& Sergiu P. Pașca. Nature. 2022 Oct 13; 610:319–326. doi:
10.1038/s41586-022-05277-w Publ 4. Long-term maturation of human cortical organoids
matches key early postnatal transitions. Gordon A, Yoon SJ, Tran SS,
Makinson CD, Park JY, Andersen J, Valencia AM, Horvath S, Xiao X, Huguenard JR,
Pașca SP, Geschwind DH. Nature Neuroscience. 2021
Mar;24(3):331-342. doi: 10.1038/s41593-021-00802-y.