Tapahtumakalenteri
Dissertation: Tommi Strausz
Opponent: Professor Timo Närhi, University of Turku
Dissertation: Abiodun Ayo
Opponent: Professor Tero Järvinen, Tampere University
HiLIFE webinar / Viikki Monday Seminar by Peter Cullen: Molecular mechanisms of endosomal cargo recycling in human health and disease
Using biochemistry and molecular cell biology, Peter Cullen has made many of the seminal discoveries that have identified the mechanisms by which hundreds of human integral membrane proteins undergo recycling through the human endosomal-lysosomal network. In performing in cellulo and in vivo analysis he has revealed how recycling regulates processes ranging from cell adhesion and migration, cell signalling and polarity through to synaptic activity and host:pathogen interactions . As dysfunction in endosomal recycling is increasingly associated with human disease, Peter’s research has made an immediate and long-lasting contribution to understanding human health and disease. Peter currently holds the Royal Society Noreen Murray Research Professor, is a Fellow of the Academy of Medical Sciences and an EMBO member.
Welcome to this exciting seminar!
Markku Varjosalo
Selected publications:
Antón-Plágaro C, et al, Cullen PJ (2024). Mapping of endosomal proximity proteomes reveals Retromer as a hub for RAB GTPase regulation. bioRix 2024.11.22.622898.
Butkovic R, et al, Cullen PJ. (2024). Mechanism and regulation of cargo entry into the Commander endosomal recycling pathway. Nat Commun 15:7180.
Healy MD*, McNally KE*, Butkovic R*, Chilton M*, et al, Cullen PJ. (2023). Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome. Cell 186:2219-2237.
Daly JL, et al, Cullen PJ. (2023). Multi-omicSpecial seminar by Prof Geert Bultynck
Prof Bultynck is the Secretary-General of European Calcium Society. He is well known for his work on intracellular Ca2+ signaling in cell survival, stress & death decisions, and particularly the BCL-2 family in Ca2+ regulation in cancer cell death. He has authored more than 260 publications. In his talk, he will focus on recent work on Ca2+-signaling dysregulation at organellar contact sites as a disease mechanism in Wolfram syndrome, a progressive neurodegenerative disorder characterized by diabetes mellitus, optic atrophy, hearing loss, dementia, ataxia, and neuropathy. Some of the publications related to this work include:
Liiv M, Vaarmann A, Safiulina D, Choubey V, Gupta R, Kuum M, Janickova L, Hodurova Z, Cagalinec M, Zeb A, Hickey MA, Huang YL, Gogichaishvili N, Mandel M, Plaas M, Vasar E, Loncke J, Vervliet T, Tsai TF, Bultynck G, Veksler V, Kaasik A.
Nat Commun. 2024 Jul 21;15(1):6143.
Loncke J, Vervliet T, Parys JB, Kaasik A, Bultynck G.
Sci Signal. 2021 Sep 28;14(702):eabc6165.
Balancing ER-Mitochondrial Ca2+ Fluxes in Health and Disease.
Loncke J, Kaasik A, Bezprozvanny I, Parys JB, Kerkhofs M, Bultynck G.
Trends Cell Biol. 2021 Jul;31(7):598-612.
For meetings with Prof Bultynck, please contact Henna Tyynismaa (henna.tyynismaa@helsinki.fi)
FuGU / FIMM Genomics Housewarming Event
Dear members of the research community,
We are delighted to invite you all to the housewarming event of the FuGU /FIMM Genomics in its new premises in Biomedicum 2 following the merger of FuGU with FIMM Genomics.
You are warmly welcome to join us for refreshments and drinks, as we show our new facilities and instruments as well as introduce you to our team. This is a wonderful opportunity to discuss about your needs in genomics services and to visit our new location.
We look very much forward to seeing you there!
On behalf of the FuGU / FIMM Genomics Team