Tapahtumakalenteri

Carla Kim is a Professor of Genetics at Boston Children's Hospital and Harvard Medical School. The broad interest of her lab is to use stem cell biology to better understand how mechanisms governing normal lung biology are impacted in disease and cancer. They created 3D co-culture organoid systems that allow them to visualize the formation of airway- and alveolar-like structures from lung epithelial progenitor cells. Using this platform, they are defining how progenitor cells are regulated by cell-cell communication between epithelial cells and mesenchymal cells. The tools they have developed also make it possible to understand the cell autonomous and paracrine mechanisms of lung progenitor cell biology that are altered in pulmonary diseases and in lung cancer. Their work is being applied to lung diseases ranging from premature infant lung disease to cystic fibrosis to diseases of aging. Their expertise in epigenetic regulation of lung cells has revealed new therapeutic approaches for particular subsets of lung cancer patients that are now being pursued in clinical studies. 

 Dr. Kim received her Ph.D. in Genetics from the University of Wisconsin—Madison in 2002 and performed postdoctoral research at the MIT Center for Cancer Research. She joined the Stem Cell Program at Children’s Hospital Boston and established her laboratory in September 2006. 

Link to group website   

@carlakimlab 

Welcome to this exciting webinar!  

Emmy Verschuren 

Selected publications: 

Dost AFM, Moye AL, Vedaie M, Tran LM, Fung E, Heinze D, Villacorta-Martin C, Huang J, Hekman R, Kwan JH, Blum BC, Louie SM, Rowbotham SP, Sainz de Aja J, Piper ME, Bhetariya PJ, Bronson RT, Emili A, Mostoslavsky G, Fishbein GA, Wallace WD, Krysan K, Dubinett SM, Yanagawa J, Kotton DN, Kim CF. Organoids Model Transcriptional Hallmarks of Oncogenic KRAS Activation in Lung Epithelial Progenitor Cells. Cell Stem Cell. 2020 Oct 1 PMID - 32891189 

Rowbotham S, Li F, Marsh B, Pessina P, Brainson C, Tuminello S, Zhang H, Schlaeger T, Wong K, Watanabe H, Dost A, Louie S, Centura A, Aronow B, Kim CF. H3K9 methyltransferases and demethylases control lung tumor-propagating cells and lung cancer progression. Nature Communications. 2018 PMID - 30455465

Lee J-H, Tammela T, Hofree M, Choi J, Marjanovic N, Han S, Canner D, Paschini M, Bhang D, Jacks T, Regev A, Kim CF.Anatomically and functionally distinct lung mesenchymal populations marked by Lgr5 and Lgr6. Cell. 2017 PMID - 28886383