Tapahtumakalenteri
Dissertation: Anna Nikula
Opponent: Professor Ian Maconochie, Imperial College Healthcare NHS Trust, London, United Kingdom
Dissertation: Viktória Roxána Balla
Opponent: Associate Professor Iria SanMiguel, Brainlab, Institute of Neurosciences, University of Barcelona
Dissertation: Inam Liaqat
Opponent: Professor Antal Rot, Queen Mary University of London, United Kingdom
Last biostatistics drop-in workshop before summer break
Are you a researcher needing support with any statistical aspect of your work? The Biostatistics Consulting Service here at Meilahti Campus holds drop-in workshop sessions every other week to answer smaller questions about your analysis - solving a particular problem, how to get started, etc. We provide service in Finnish, English and Swedish.
The next workshop - and the last one of the season - is on Wednesday 28th May, at 13:00-15:00 in Biomedicum 2B, in the Olohuone on floor 6. Come whenever you can. Note that you may end up waiting a while for your turn, especially early on in the session. We aim to spend no more than 15 minutes with each customer.
Bring:
- your computer
- your data
- your questions
and we biostatisticians will be on hand to help and guide.
Registration is not required, but you can help us prepare for your questions by filling in this form. The workshops are open to any researcher at the university's Medical Faculty, HUS or FIMM.
After this session we will take a summer break before starting again in August/September.
For more in-depth questions, please book a one-on-one consultation session using this e-form where we will have time to go into more detail. That service will continue throughout the summer.
From the Biostatistics Team
Seminar by Francesco Padovani
Francesco Padovani from Helmholtz Zentrum Munich (Germany) will give a seminar on May 30th: 11AM-12PM
Mitochondrial DNA copy number and nucleoid number control mechanisms
Francesco Padovani develops
AI-driven bioimage analysis tools like Cell-ACDC and SpotMAX, which are
user-friendly for experimental scientists without advanced technical expertise.
These tools are widely adopted globally and have helped uncover key molecular
regulators of mtDNA homeostasis while advancing accessibility to AI-driven
bioimage analysis frameworks.
Abstract
Mitochondria have their genome, the mitochondrial DNA (mtDNA), which encodes
for essential subunits of the respiratory pathway and is maintained in multiple
copies distributed throughout a highly dynamic mitochondrial network. Defects
in mtDNA maintenance are linked to metabolic, cardiac, and neurodegenerative
diseases, as well as many types of cancer. While we know mtDNA copies are
packaged by DNA-binding proteins into globular-like structures called nucleoids
(1-3 copies per nucleoid), the molecular mechanisms regulating mtDNA copy
number (mtDNA-CN) and nucleoid number remain unclear. Combining quantitative
microscopy with novel AI-driven bioimage analysis tools, we identified crucial
molecular players regulating mtDNA-CN in the model organism S. cerevisiae.
However, we also reveal that mtDNA-CN is partially uncoupled from nucleoid
number control, raising questions on how this fundamental homeostasis is
achieved.
Selected papers:
SpotMAX: a generalist framework for multi-dimensional automatic spot detection and quantification
Francesco Padovani, Ivana Čavka, Ana Rita Rodrigues Neves, Cristina Piñeiro López, Nada Al-Refaie, Leonardo Bolcato, Dimitra Chatzitheodoridou, Yagya Chadha, Xiaofeng A Su, Jette Lengefeld, Daphne S Cabianca, Simone Köhler, Kurt M Schmoller, bioRxiv, 2024
Segmentation, tracking and cell cycle analysis of live-cell imaging data with Cell-ACDC
F Padovani, B Mairhörmann, P Falter-Braun, J Lengefeld, KM Schmoller, BMC biology 20 (1), 174
Regulation with cell size ensures mitochondrial DNA homeostasis during cell growth
Anika Seel, Francesco Padovani, Moritz Mayer, Alissa Finster, Daniela Bureik, Felix Thoma, Christof Osman, Till Klecker, Kurt M Schmoller, Nature Structural & Molecular Biology, 2023
Welcome to this exciting seminar!
Jette Lengefeld