Tapahtumakalenteri

Professor Lilach Sheiner from the University of Glasgow, UK will give a talk in the HiLIFE seminar series on May 26th at 13.00-14.00.  

Coffee and pulla will be served in front of the lecture hall 30 minutes prior to the seminar.

Keep it together! How >50 rRNA fragments create the Toxoplasma mitoribosome

Lilach Sheiner, is a Professor in Parasitology at the University of Glasgow and a co-director of the Glasgow Centre for Parasitology. She leads a team focused on mitochondrial biology of apicomplexan, and on divergent cell biology of eukaryotes.

Throughout her career Lilach has been researching divergent cell biology, primarily focused on Toxoplasma as an apicomplexan model organism. Her PhD at the university of Geneva Switzerland was focused on intracellular trafficking of Toxoplasma membrane proteins, and her postdoctoral work at the Center of Tropical and Emerging Global Diseases, GA, USA, was focused on apicoplast protein import. In the past 11 years Lilach and her team at Glasgow have developed new techniques and protocols for the study of mitochondrial biology in Toxoplasma which they have been using to explore its unique biology and biogenesis. 

Sheiner Lab

Welcome to this exciting seminar!

Brendan Battersby and Alex Mühleip

Selected publications:

Shikha Shikha, Victor Tobiasson, Mariana Ferreira Silva, Jana Ovciarikova, Dario Beraldi, Alexander Mühleip, Lilach Sheiner. Numerous rRNA molecules form the apicomplexan mitoribosome via repurposed protein and RNA elements. Nat Commun 2025 Jan 18;16(1):817. doi: 10.1038/s41467-025-56057-9. PMID: 39827269.

Jana Ovciarikova, Shikha Shikha, Alice Lacombe, Flavie Courjol, Rosalind McCrone, Wasim Hussain, Andrew Maclean, Leandro Lemgruber, Erica S Martins-Duarte, Mathieu Gissot, Lilach Sheiner. Two ancient membrane pores mediate mitochondrial-nucleus membrane contact sites. J Cell Biol. 2024 Apr 1;223(4):e202304075. doi: 10.1083/jcb.202304075. PMID: 38456969.

Mariana F Silva, Kiera Douglas, Sofia Sandalli, Andrew E Maclean, Lilach Sheiner. Functional and biochemical characterization of the Toxoplasma gondii succinate dehydrogenase complex. PLoS Pathog. 2023 Dec 11;19(12):e1011867. doi: 10.1371/journal.ppat.1011867. PMID: 38079448.

Andrew E Maclean, Hannah R Bridges, Mariana F Silva, Shujing Ding, Jana Ovciarikova, Judy Hirst, Lilach Sheiner. Complexome profile of Toxoplasma gondii mitochondria identifies divergent subunits of respiratory chain complexes including new subunits of cytochrome bc1 complex. PLoS Pathog. 2021 Mar 2;17(3):e1009301. doi: 10.1371/journal.ppat.1009301. PMID: 33651838.

Alexander Mühleip, Rasmus Kock Flygaard, Jana Ovciarikova, Alice Lacombe, Paula Fernandes, Lilach Sheiner, Alexey Amunts. ATP synthase hexamer assemblies shape cristae of Toxoplasma mitochondria. Nat Commun. 2021 Jan 5;12(1):120. doi: 10.1038/s41467-020-20381-z. PMID: 33402698.

And a "fun outlier" paper: 

Shahar Bracha, Hannah J Johnson, Nicole A Pranckevicius, Francesca Catto, Athena E Economides, Sergey Litvinov, Karoliina Hassi, Marco Tullio Rigoli, Cristina Cheroni, Matteo Bonfanti, Alessia Valenti, Sarah Stucchi, Shruti Attreya, Paul D Ross, Daniel Walsh, Nati Malachi, Hagay Livne, Reut Eshel, Vladislav Krupalnik, Doron Levin, Stuart Cobb, Petros Koumoutsakos, Nicolò Caporale, Giuseppe Testa, Adriano Aguzzi, Anita A Koshy, Lilach Sheiner, Oded Rechavi. Engineering Toxoplasma gondii secretion systems for intracellular delivery of multiple large therapeutic proteins to neurons. Nat Microbiol. 2024 Aug;9(8):2051-2072. doi: 10.1038/s41564-024-01750-6. PMID: 39075233.