Tapahtumakalenteri
FICAN science webinar by Anssi Auvinen
Speaker: prof. Anssi Auvinen, Tampere University
This webinar is organized by FICAN MID (Sisä-Suomen syöpäkeskus). The webinar will be held online in Teams (link below) and is open to everyone interested in cancer research.
Abstract:
We have
shown in the ERSPC trial that PSA-based screening can reduce prostate cancer
mortality, but due to extensive overdiagnosis of low-risk cases, the balance of
benefits and harms is questionable.
We have designed a screening protocol aimed at minimising overdiagnosis, but maintaining the mortality impact. The screening intervention consist of three tests, provided in a stepwise fashion: First PSA, for men with PSA3 ng/ml also a kallikrein panel (4Kscore) and if it exceeds 7.5%, a referral to MRI. Men with a suspicious MRI findings (PI-RADS score 3–5) are referred to targeted prostate biopsy.
We
have randomised 113,357 men aged 50–63 from Helsinki and Tampere metropolitan
areas, with a quarter allocated to screening and the rest to the control arm.
Results from the first screening round show that large majority (80%) of the
screen-detected cases are high-grade cancers (ISUP grade group 2–5). Compared
with the control arm, one additional high-grade cancer was detected per 200
men, while the excess of low-grade cases (grade group 1) was considerably
smaller (one excess case per 800 men).
References
Auvinen A, Tammela T, Mirtti T, et al. Prostate cancer screening with PSA, kallikrein panel and MRI: The ProScreen randomized trial. JAMA 2024;331:1452-59
Rannikko A, Leht M, Mirtti T, ym. Population-based randomized trial of screening for clinically significant prostate cancer: A pilot study. BJU Int 2022;130:193-199
Bratt O, Auvinen A, Godtman AR, ym. Screening for prostate cancer. BMJ Oncol 2023;2:e000039
More information about the speaker:
https://www.tuni.fi/en/about-us/epidemiology#switcher-trigger-overview
Data visualization - join discussion at ReproducibiliTea
Dear all,
Welcome to the May installment of our ReproducibiliTea club - the final one of the season!
Data visualization: a friend and foe of data interpretation
Data visualization is the unspoken language of research. When used well, it helps communicate complex findings at a glance—but it can also mislead when used to obscure key details. In this final club of the season, we will explore best practices for crafting clear, honest, and effective visuals. Bring your favorite tips and tricks, and get inspired by others!
📚 Reading material
Weissgerber, Tracey L et al. “Reveal, Don't Conceal: Transforming Data Visualization to Improve Transparency.” Circulation vol. 140,18 (2019): 1506-1518. doi:10.1161/CIRCULATIONAHA.118.037777 [PDF link]
Bring your questions, ideas, curiosity and join us for a fruitful discussion (and some tea, of course)!
Yours truly,
ReproducibiliTea UniHelsinki Team
Minerva seminar by Professor Meredith Hawkins
"Type 5 diabetes - a new global challenge"
Professor Meredith Hawkins
Albert Eistein College of Medicine
New York, USA
Can you dream big and believe in goals that seem unrealistic? If you need encouragement, please come and listen to the journey which lead to type 5 diabetes finally being recognized as a new global challenge. Meredith Hawkins is professor of endocrinology at Albert Eistein College of Medicine in New York. Please come and listen to her incredible story May 23, at 11.45 at the Faculty Club at Biomedicum 1!
📅 When? Friday
May 23rd at 11:45
📍 Where? Faculty Club, Biomedicum 1
To secure your lunch, please register to cia.olsson@minervainstitute.fi by email by May 16, 2025.
Dissertation: Maria Lovén
Opponent: Professor Mats Brommels, Karolinska Institutet
Dissertation: Pauliina Repo
Opponent: Professor Sapna Patel, Medicine-Medical Oncology, University of Colorado Cancer Center, USA