Heroes and villains: Immune cells regulating metastasis
Professor Mikala Egeblad obtained degrees in Medicine (B.S., 1993). Human Biology (M.Sc., 1996), and in Cancer Biology (Ph.D., 2000) from the University of Copenhagen, Denmark. She did her dissertation research under the mentorship of Dr. Marja Jäättelä at The Danish Cancer Society. Her postdoctoral training was performed in the laboratory of Dr. Zena Werb at University of California, San Francisco. There, she began developing intravital spinning disk confocal microscopy to understand how the microenvironment influences tumor progression, focusing on innate immune cell responses and protease-mediated extracellular matrix remodeling. She came to Cold Spring Harbor Laboratory in 2009 and established a research group that studies how the tumor microenvironment contributes to therapy resistance and metastasis, primarily focusing on the role of inflammatory cells. In 2014, she was promoted to Associate Professor and in January 2021 to Professor.
Sun, L., Kees, T., Almeida, A. S., Liu, B., ... and Egeblad, M. (2020). Activating a collaborative innate-adaptive immune response to control breast and ovarian cancer metastasis. bioRxiv, 2020/200477; https://doi.org/10.1101/2020.07.13.200477
Fein, M. R., He, X. Y., Almeida, A. S., Bruzas, E., ... and Egeblad, M. (2020). Cancer cell CCR2 orchestrates suppression of the adaptive immune response. Journal of Experimental Medicine. https://doi.org/10.1084/JEM.20181551
Middleton, EA, He, X.-Y., Denorme, F, Campbell, RA, … and Egeblad, M., Schiffman, JD., Con Yost, C. (2020). Neutrophil Extracellular Traps (NETs) Contribute to Immunothrombosis in COVID-19 Acute Respiratory Distress Syndrome. Blood. https://doi.org/10.1182/blood.2020007008
Barnes, B. J., Adrover, J. M., Baxter-Stoltzfus, A., Borczuk, A., … and Egeblad, M. (2020). Targeting potential drivers of COVID-19: Neutrophil extracellular traps. In Journal of Experimental Medicine. https://doi.org/10.1084/jem.20200652
Albrengues, J., Shields, M. A., Ng, D., Park, C. G., Ambrico, A., … and Egeblad, M. (2018). Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice. Science. https://doi.org/10.1126/science.aao4227
Park, J., Wysocki, R. W., Amoozgar, Z., Maiorino, L., ... and Egeblad, M. (2016). Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps. Science Translational Medicine. https://doi.org/10.1126/scitranslmed.aag1711
Find below more information on Professor Egeblad’s research and recent publications:
We welcome you to this exciting seminar.
CancerBio Summer School organizing team
Juha Klefström, Jeroen Pouwels,
Mariel Savelius, Krista Tuohinto,
Dipabarna Bhattacharya & Anna Laury