Tapahtumakalenteri

Paul Boutz Bio:

Professor Paul Boutz’ research group is based at Rochester University, New York, USA. Prior to starting his independent career, Dr Boutz was a Postdoc in Nobel Laureate Dr. Phillip Sharp’s group at Massachusetts Institute of Technology (MIT), where he discovered a novel class of introns, termed ‘detained introns’. He is trained as a molecular biologist (PhD) and developed broad expertise in computational biology during his Postdoctoral training.

Dr Boutz’s team develops novel algorithms to classify and annotate the structures of genes in order to understand how transcriptional and post-transcriptional processes shape the quantity and quality of the cellular transcriptome, and to uncover novel alternative splicing events and alternative polyadenylation sites that play important roles in both normal physiology as well as the development and progression of diseases, particularly cancer. They utilize deep-learning neural networks and long-read sequencing to gain insights into the cis-acting RNA sequence elements in response to pharmacological interventions or disease-causing mutations.

In brief, Dr Boutz has deep technical and biological understanding in the areas of RNA processing and gene expression regulation in health and disease.

Boutz lab website:

https://www.urmc.rochester.edu/people/112361806-paul-l-boutz

Selected publications:

Pan Y, Adachi H, He X, Chen JL, Yu Y*, Boutz PL*. Updated Pseudo-seq Protocol for Transcriptome-Wide Detection of Pseudouridines. Bio-Protocol 2024.

Insco ML, Abraham BJ, Dubbury SJ, Dust S, Kaltheuner IH, Wu C, Chen KY, Liu D, Bellaousov S, Cox AM, Martin BJE, Zhang T, Ludwig CG, Fabo T, Modhurima R, Esgdaille DE, Henriques T, Brown K, Chanock SJ, Geyer M, Adelman K, Sharp PA, Young RA, Boutz PL, Zon LI. Oncogenic CDK13 Mutations Impede Nuclear RNA Surveillance. Science 2023.

Adachi H, Pan Y, He X, Chen JL, Klein B, Platenburg G, Morais P, Boutz PL*, Yu YT*. Targeted pseudouridylation: An approach for suppressing nonsense mutations in disease genes. Molecular Cell 2023.

Tan ZW, Fei G, Paulo JA, Bellaousov S, Martin SES, Duveau DY, Thomas CJ, Gygi SP, Boutz PL*, Walker S*.  O-GlcNAc regulates gene expression by controlling detained intron splicing. Nucleic Acids Res 2020.

Dubbury SJ*, Boutz PL*, Sharp PA. *Co-first authors. CDK12 regulates DNA repair genes by suppressing intronic polyadenylation. Nature 2018.

Braun CJ*, Stanciu M*, Boutz PL*, Patterson JC, Calligaris D, Higuchi F, Neupane R, Fenoglio S, Cahill DP, Wakimoto H, Agar NYR, Yaffe MB, Sharp PA, Hemann MT, Lees JA. Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma. Cancer Cell 2017.