Tapahtumakalenteri (vanha)
FICAN webinar by prof Kimmo Porkka
professor Kimmo Porkka
Department of Oncology, University of Helsinki and
HUS Helsinki University Hospital
Get to know the Speaker: Professor of personalized cancer medicine; chief physician Kimmo Porkka – University of Helsinki Research Portal
This time the seminar is organized by FICAN South. The seminar will be held online (Microsoft Teams), find the link below.
The event is open to everyone interested in cancer research.
Science talks of NC group leader candidates
9.00 - 9.15 Opening words by Neuroscience Center Director Satu Palva
9.15 – 9.45 Daniela Calvigioni, Neuroscience Department, Karolinska Institutet
Title of the talk: Hormone sensitive networks shape emotional brain states
9.45 – 10.15 Raunak Basu, Edmond and Lily Safra Center for Brain Sciences at the Hebrew University of Jerusalem
Title of the talk: Mapping the world around us: A topology preserved schema of space in the Orbitofrontal cortex
Dissertation: Hazem Ibrahim
Opponent: Professor Raphael Scharfmann, Université Paris Cité,
UHBrain seminar by Professor Petra Wahle
Speaker. Professor Petra Wahle ( Developmental Neurobiology, Faculty of Biology and Biotechnology, Ruhr University, Bochum, Germany).
Abstract: We have studied the role of ionotropic receptors for dendritic growth of neocortical interneurons (our preferred prey) and pyramidal cells (the "bycatch", but also delivering stories) over the past years, and I'll report some recent findings including work on GPCR-coupled receptors. Further, we recently turned to interneuronal axons, many of which emerge actually from dendrites, not somata. These privileged dendrites have been termed "axon-carrying dendrites, AcD". When depolarized they can fire the axon without somatic integration avoiding somatic inhibition. The proportion of AcD cells varies between cell type, cortical layers, and mammalian species. We started to look for a developmental influence of such AcDs and the axon it carries. The picture emerging is that both are in a mutual growth-promoting relationship, and - up to debate - our recent findings argue for a role of GluN2D-containing NMDA receptors. Finally, something to muse on: what about cells with more than one axon?
Lab website: https://www.ruhr-uni-bochum.de/neurobiol/ag_wahle/index.html.en
Recent publications :
Gonda S, Riedel C, Reiner A, Köhler I, Wahle P. (2023) Axons of cortical basket cells originating from dendrites develop higher local complexity than axons emerging from basket cell somata. Development. 2023 Nov 15;150(22):dev202305.
doi: 10.1242/dev.202305.
Gasterstädt
I, Schröder M, Cronin L, Kusch J, Rennau LM, Mücher B, Herlitze S, Jack A,
Wahle P. (2022)
Chemogenetic Silencing of Differentiating Cortical Neurons Impairs Dendritic
and Axonal Growth. Front Cell Neurosci. 2022 Jul 15;16:941620. doi:
10.3389/fncel.2022.941620.
Wahle P, Sobierajski E, Gasterstädt I, Lehmann N, Weber S, Lübke JHR, Engelhardt M, Distler C, Meyer G. (2022)
Neocortical pyramidal neurons with axons emerging from dendrites are frequent in non-primates, but rare in monkey and human.
Elife. 2022 Apr 20;11:e76101. doi: 10.7554/eLife.76101.
Sobierajski
E, Lauer G, Aktas M, Beemelmans C, Beemelmans C, Meyer G, Wahle P (2022)
Development of microglia in fetal and postnatal neocortex of the pig, the
European wild boar (Sus scrofa) J Comp Neurol. 2022 Jun;530(9):1341-1362.
doi: 10.1002/cne.25280.
Gonda
S, Giesen J, Sieberath A, West F, Buchholz R, Ziebarth T, Klatt O, Räk A,
Kleinhubbert S, Riedel C, Hollmann M, Hamad MIK, Reiner A, Wahle P (2020)
GluN2B but not GluN2A for basal dendritic growth of cortical pyramidal neurons
Frontiers in Neuroanatomy 2020
Neumann
JR, Dash-Wagh S, Jack A, Räk A, Jüngling K, Hamad MIK, Pape HC, Kreutz MR,
Puskarjov M5, Wahle P (2019)
The primate-specific peptide Y-P30 regulates morphological maturation of
neocortical dendritic spines.
PLoS One. 2019 Feb 13;14(2):e0211151. doi: 10.1371/journal.pone.0211151.
Jack A, Hamad MIK, Gonda S, Gralla S, Pahl S, Hollmann M, Wahle P (2018) Development of Cortical Pyramidal Cell and Interneuronal Dendrites: a Role for Kainate Receptor Subunits and NETO1. Mol Neurobiol. 2018 Nov 12. doi: 10.1007/s12035-018-1414-0.