Tapahtumakalenteri (vanha)

kesäkuu 07

ONCOSYS Special seminar: Lecture by Prof. Douglas A. Lauffenburger (MIT)

A New Approach to Genome-Scale Modeling of Intracellular Signaling: Neural Networks Constrained by Prior Knowledge Interactomes

ABSTRACT: Mammalian cells adapt their phenotypic state in response to ligand stimuli binding cell surface receptors, inducing modulation of a complex network of intracellular molecular interactions that govern cell regulatory and functional processes. Computational modeling of the information flow through this network could help predict cell behaviors in health and disease. However, obtaining sufficient experimental data to construct reliable models comprising adequate parameterization continues to be a severe problem. To address this challenge, we have recently developed a new approach: integrating a neural network machine learning framework constrained by prior knowledge of the intracellular protein-protein interactome. This approach can generate an operational model based on ligand inputs and corresponding transcriptional profile outputs. We demonstrate utility in immune cell signaling applications, including macrophages and CAR T-cells, and describe potential wider use such as for tumor cells.

Biography (from the National Academy of Engineering)
Douglas A. Lauffenburger is the Ford Professor of Bioengineering in the Departments of Biological Engineering, Chemical Engineering, and Biology at MIT. He was the founding head of the Department of Biological Engineering and served in that capacity from 1998 until 2019. He also holds affiliations with the Center for Biomedical Engineering, Center for Gynepathology Research, and Koch Institute for Integrative Cancer Research at MIT, as well as the Ragon Institute of MGH, MIT, and Harvard. Before joining MIT in 1995, he was a member of the faculty at the University of Pennsylvania (1979–90) and University of Illinois at Urbana-Champaign (1991–94).

A central focus of the Lauffenburger research program is systems biology approaches to cell-cell communication and cell signaling important in pathophysiology, with emphasis on translational application to therapeutics discovery and development in cancer, pathogen infection, and inflammatory disease.

Dr. Lauffenburger coauthored the monograph Receptors: Models for Binding, Trafficking, and Signaling (Oxford Press, 1993) and coedited the book Systems Biomedicine: Concepts and Perspectives (Elsevier Press, 2010). More than 130 doctoral students and postdoctoral associates have undertaken research education under his supervision.

He has served as president of the Biomedical Engineering Society, chair of the College of Fellows of American Institute for Medical and Biological Engineering, a member of the advisory council for the National Institute of General Medical Sciences, and a coauthor of the 2009 National Research Council report A New Biology for the 21st Century. He has also been a scientific advisor to numerous biotech/pharma companies and biomedical science foundations.

Along with many honors and awards from professional societies, Professor Lauffenburger is a member of the NAE and American Academy of Arts & Sciences, and a fellow of the American Association for Advancement of Science and the American Scientific Affiliation.

Professor Lauffenburger’s BS and PhD degrees are in chemical engineering, from the University of Illinois (1975) and the University of Minnesota (1979) respectively.
Aloitusaika: 07.06.2023 16:15
Lopetusaika: 07.06.2023 17:00
Kesto: 45 minutes
Sijainti: Biomedicum1, lecture hall 3, Haartmaninkatu 8, 00290 Helsinki
Tyyppi: Seminar
Organisaatio: Research Program Systems Oncology (ONCOSYS)
Yhteyshenkilö: karen.ahlnas@helsinki.fi
kesäkuu 08

Dosentin arvon hakijoiden opetusnäytteet



12:00-12:30 Lääketieteen tohtori Petri Arvilommi (psykiatria) aihe: Kaksisuuntainen mielialahäiriö ja työkyky; kohderyhmänä: Psykiatriaan erikoistuvat lääkärit.


12:30-12:40 Tauko


12:40-13:10 Lääketieteen tohtori Pirkka Pekkarinen (anestesiologia ja tehohoito) aihe: Tulehdusreaktio sydänpysähdyksen jälkeen teho-osastolla; kohderyhmänä: Anestesiologian ja tehohoidon erikoistuvat lääkärit.


13:10-13:20 Tauko


13:20-13:50 Filosofian tohtori Maija Miettinen (kansanterveystiede) aihe: Tutkijan vastuu epidemiologisten tulosten esittämisestä; kohderyhmänä: Kansanterveystieteen tohtoriopiskelijat.


13:50-14:00 Tauko


14:00-14:30 Hammaslääketieteen tohtori Kaija Hiltunen (hammaslääketieteellisen protetiikka ja gerodontologia) aihe: Mitä ikääntyvän suun terveydelle kuuluu?; kohderyhmänä: Lääkäri ja hammaslääkäri opiskelijat.


14:30-14:40 Tauko


14:40-15:10 Filosofian tohtori Netta Mäkinen (molekyyligenetiikka) aihe: High-throughput DNA sequencing in cancer research; kohderyhmänä: Master's and graduate students who have already previous knowledge of genetics.


15:10-15:20 Tauko


15:20-15:50 Lääketieteen tohtori Kirsi Skogberg (infektiotautioppi) aihe: Mikrobilääkkeen valinnan periaatteet sairaalassa; kohderyhmänä: Loppuvaiheen lääketieteen opiskelijat.

Aloitusaika: 08.06.2023 12:00
Lopetusaika: 08.06.2023 16:00
Kesto: 3 hours
Sijainti: remotely
Tyyppi: Docententship lecture
Organisaatio: UH, Faculty of Medicine
Yhteyshenkilö: anni.korjo@helsinki.fi
kesäkuu 09

Dissertation: Riitta Tuompo

Riitta Tuompo, University of Helsinki, Faculty of Medicine, Doctoral Program in Clinical Research
Infection and Early Arthritis – New Aetiological Agents with Respect to Reactive Arthritis
Opponent: docent Johanna Huhtakangas, University of Eastern Finland

Aloitusaika: 09.06.2023 12:00
Lopetusaika: 09.06.2023 14:00
Kesto: 2 hours
Sijainti: Biomedicum1, lecture hall 1, Haartmaninkatu 8, 00290 Helsinki
Tyyppi: Dissertation
Organisaatio: UH, Faculty of Medicine
Yhteyshenkilö: riitta.tuompo@hus.fi
kesäkuu 09

Dissertation: Niina Sahrakorpi

​Niina Sahrakorpi, University of Helsinki, Faculty of Medicine, Doctoral Program in Clinical Research
Determinants of Health-Related Quality of Life from Pregnancy to Early Years of Motherhood - Focus on Obesity and Gestational Diabetes

Opponent: docent Riitta Luoto, University of Tampere

Aloitusaika: 09.06.2023 12:00
Lopetusaika: 09.06.2023 14:00
Kesto: 2 hours
Sijainti: Naistenklinikka, Seth Wichmann -sali, Haartmaninkatu 2
Tyyppi: Dissertation
Organisaatio: UH, Faculty of Medicine
Yhteyshenkilö: niina.sahrakorpi@helsinki.fi
kesäkuu 09

Dissertation: Johanna Nukari

​Johanna Nukari, University of Helsinki, Faculty of Medicine, Department of Psychology and Logopedics, Doctoral Programme in Cognition, Learning, Instruction and Communication (CLIC)
Effectiveness of individual and group-based neuropsychological interventions for young adults with dyslexia
Opponent: docent Päivi Hämäläinen, University of Turku

Aloitusaika: 09.06.2023 13:00
Lopetusaika: 09.06.2023 15:00
Kesto: 2 hours
Sijainti: Biomedicum1, lecture hall 2, Haartmaninkatu 8, 00290 Helsinki
Tyyppi: Dissertation
Organisaatio: UH, Faculty of Medicine
Yhteyshenkilö: johanna.nukari@kuntoutussaatio.fi