Tapahtumakalenteri (vanha)

Dr. Taija Mäkinen’s lab’s research interests lie in the understanding of mechanisms that regulate the lymphatic vasculature in development, homeostasis and disease. A major interest of her laboratory is to elucidate how (lymphatic) endothelial cells integrate signals from multiple sources in a complex tissue environment to coordinate vascular morphogenesis and functional specialization. Recently their work has extended to studying how endothelial cells actively modulate their environment through intercellular communication with other cell types, and how regulators of developmental (lymph)angiogenesis impact on genetic human diseases.

http://www.makinenlab.com/

Selected publications:

Petkova M, Kraft M, Stritt S, Martinez-Corral I, Ortsäter H, VanlandewijckM, Jakic B, Baselga E, Castillo SD, Graupera M, BetsholtzC, Mäkinen T. Immune-interacting lymphatic endothelial subtype at capillary terminals drives lymphatic malformation. J Exp Med. (2023).

Hernández Vásquez MN, Ulvmar MH, González-Loyola A, Kritikos I, Sun Y, He L, Halin C, Petrova TV, Mäkinen T. Transcription factor FOXP2 is a flow-induced regulator of collecting lymphatic vessels. EMBO J 40(12):e107192. doi: 10.15252/embj.2020107192 (2021).

Martinez-Corral I, Zhang Y, Petkova M, Ortsäter H, Sjöberg S, Diez SC, Brouillard P, Libbrecht L, Graupera M, AlitaloK, Boon L, Vikkula M, Mäkinen T. Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation. Nat Commun 11:2869 doi: 10.1038/s41467-020-16496-y (2020).

Frye M, Stritt S, Ortsäter H, Hernandez-Vasquez M, Kaakinen M, Vicente A, Wiseman J, Eklund L, Martinez-Torrecuadrada JL, Vestweber D, Mäkinen T. EphinB2-EPHB4 signalling provides Rho-mediated homeostatic control of lymphatic endothelial cell junction integrity. eLife 9:e57732 (2020).

Please contact Kari Vaahtomeri (kari.vaahtomeri@helsinki.fi) for an appointment with the speaker.