Tapahtumakalenteri
Biostatistics drop-in workshop
The next workshop is on Wednesday 2nd November, at 13:00-15:00 in Biomedicum 2, 6th floor Olohuone. Come when you can, stay as long as you need to. Folowing sessions are at the same time on 16th November, 30th Novemeber, and 14th December.
Bring:
- your computer
- your data
- your questions
and we biostatisticians will be on hand to help and guide.
Registration is not required, but you can help us prepare for your questions by filling in this form. The workshops are open to any researcher at the university's Medical Faculty, HUS or FIMM. Details will soon be available on our webpage.
For more in-depth questions, please book a one-on-one consultation session using this e-form where we will have time to go into more detail.
From the Biostatistics Team
Hanna, Olavi & Ville
Metabolomics symposium
We’re pleased to invite you to face-to-face Metabolomics Symposium 2-3
November. See the full program below and
the flyer attached!
PLEASE REGISTER HERE: https://elomake.helsinki.fi/lomakkeet/119388/lomake.html
Students, come and
earn credits!
SCHEDULE
Wednesday 2nd Nov
MEILAHTI Biomedicum, Hall 3, Haartmaninkatu 8
9.15-9.20 Opening words by Prof. Teemu Teeri, PI of
the Metabo-HiLIFE Metabolomics Platform
TOPIC 1 Metabolomics data analysis
9.20-10.05 Hans Stenlund, Umeå University, SWE:
“Chemometrics in Metabolomics – what, how and why”
coffee
10.30-11.15 Kati Hanhineva, UTU: “Notame-pipeline
in food and nutritional metabolomics data-analysis”
11.15-12.00 Zhixu Ni, TU Dresden, GER: ”LC-MS based
(epi)Lipidomics data analysis and integration workflows”
LUNCH (own
expense)
TOPIC 2 MS-based
imaging - DESI & SIMS
13.30-14.15 John Fletcher, University of
Gothenburg, SWE: “Secondary ion mass spectrometry – making the leap from
semiconductors to biology”
14.15-15.00 Ingela Lanekoff, Uppsala University,
SWE: "Quantitative mass spectrometry imaging with nano-DESI"
15.00-15.30 Wei Rao, Waters: "High resolution
mass spectrometry imaging of metabolites with DESI and MALDI"
coffee
MS-based imaging - MALDI
15:45-16.15 Seppo Auriola, UEF: ”MALDI imaging mass
spectrometry in ocular drug research”
16:15-16.45 Andras Kiss, Bruker: "MALDI Mass
Spectrometry Imaging is more than pretty images"
Thursday 3rd Nov VIIKKI Biocenter 2, Hall 2041, Viikinkaari 5
TOPIC 3 LIPIDOMICS
9.15-10.15 Kim Ekroos, Lipidomics Consulting: “Lipidomics
- A Central Field for Advancing Human Health”
coffee
10.45-11.15 Martjin
Molenaar, Utrecht University, NL: "LION/web: a web-suite for
lipidomics data analysis"
11.15-11.45 Satu
Lehti, JYU: “High density cholesterol changes across menopausal change”
11.45-12.15 Cagakan Ozbalci, SCIEX:
"Advancements for metabolomics and lipidomics workflows on ZenoToF
7600"
LUNCH (own expense)
TOPIC 4
FLUXOMICS AND METABOLIC PROFILING
13.30-14.30 Roland Nilsson, Karolinska
Institutet, SWE: “Towards systematic metabolic flux analysis in human cells and
tissues”
14.30-15.00 Jeffrey Barret,
Nightingale: "Nightingale blood biomarkers and preventative
health"
coffee
15.30-16.00 Nyasha
Munjoma, Waters: “Lipidomic and DESI imaging study of mouse liver extracts
dosed with tyrosine kinase inhibiting drug”
16.00-16.45 Rahul
Deshpande, Thermo Fisher Scientific: “From data to knowledge:
Intelligence-driven workflow solutions for Metabolomics”
Students - ILS-149 course - 1 cr
Obligatory attendance to all 4 seminar
topics during the 2-day symposium (signature required).
Writing of 4 learning diaries, 1
learning diary from each seminar topic (each 1 page long). Send the learning
diaries to minna.holopainen@helsinki.fi
Metabolomics Symposium is organized by Viikki
Metabolomics Unit (ViMU), FIMM Metabolomics/Lipidomics/Fluxomics Unit (FIMM
Meta) and Helsinki University Lipidomics Unit (HiLIPID).
The symposium is
sponsored by Waters.
FiCAN Seminar: Johanna Ivaska
Johanna Ivaska FCI K. Albin Johansson Research Professor University of Turku Organized by FICAN West
Abstract: Our research focuses on the fundamental role of cell-cell and cell-extracellular matrix crosstalk in maintaining tissue homeostasis. During tumour development, these pathways are altered and trigger the formation of environments that are physically and biochemically more conducive to cancer growth. Recently, we showed that expression of a motor protein MYO10, and MYO10-dependent filopodial extensions, while detrimental in invasive breast cancer and associated with poor patient survival, is protective at the early stage. In pre-invasive ductal carcinoma in situ (DCIS), MYO10 maintains a continuous basement-membrane border around the tumours and prevents dissemination into the surrounding stroma. Therefore, any therapeutic targeting of MYO10 must consider the dual actions of this motor protein and cancer stage. In another work (unpublished), we employed microfluidics to mimic cancer cell interaction with the vasculature (endothelial cell layer) under flow. We found that the method used by cancer cells to cross the endothelial cell barrier differs across cell types but is dependent on cancer-cell–endothelial-cell interaction, often involving the extension of filopodia-like protrusions. We are now employing single-cell mass CyToF and other innovative techniques to understand the molecular details of this interaction and identify a potential therapeutic target.
Relevant references for this talk:
E. Peuhu*, G. Jacquemet*, C. Scheele, A. Isomursu, M-C. Laisne, L.M. Koskinen, I. Paatero, K. Thol, M. Georgiadou, C. Guzmán, S. Koskinen, A. Laiho, L.L. Elo, P. Boström, P. Hartiala, J. van Rheenen, and J. Ivaska*. MYO10-filopodia support basement membranes at pre-invasive tumor boundaries. Developmental Cell (In Press). An earlier version available in the pre-print server bioRxiv. https://doi.org/10.1101/2021.10.22.464987.
Jacquemet G, Paatero I, Carisey AF, Padzik A, Orange JS, Hamidi H, Ivaska J. FiloQuant reveals increased filopodia density during breast cancer progression. J Cell Biol. 2017 Oct 2;216(10):3387-3403. doi: 10.1083/jcb.201704045.
Arjonen A, Kaukonen R, Mattila E, Rouhi P, Högnäs G, Sihto H, Miller BW, Morton JP, Bucher E, Taimen P, Virtakoivu R, Cao Y, Sansom OJ, Joensuu H, Ivaska J. Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis. J Clin Invest. 2014 Mar;124(3):1069-82. doi: 10.1172/JCI67280.
Kliinisen mikrobiologian perjantaisarja
Milka Hammarén, FT, Suomen Akatemian tutkijatohtori
Dissertation: Markku Vuorinen
Opponent: professor Ville Mattila, University of Tampere