Tapahtumakalenteri

lokakuu 07

Dissertation: Giorgio Turconi

​Giorgio Turconi, University of Helsinki, Faculty of Medicine, Doctoral Programme in Biomedicine
New roles of glial cell line-derived neurotrophic factor GDNF in motor and cholinergic functions

Opponent: Professor Deniz Kirik, Lund University



Aloitusaika: 07.10.2022 14:00
Lopetusaika: 07.10.2022 16:00
Kesto: 2 hours
Sijainti: Porthania PII, Yliopistonkatu 3, Helsinki
Tyyppi: Dissertation
Organisaatio: UH, Faculty of Medicine
Yhteyshenkilö: giorgio.turconi@helsinki.fi
lokakuu 10

HiLIFE Webinar: Ryan Flynn

​glycoRNAs: bridging the gap between glycobiology and RNA biology

Ryan is a New Jersey native who completed his undergraduate training at MIT, where he worked in the lab of Phillip Sharp on small noncoding RNA biology. Subsequently he moved to Stanford where he completed his M.D. and Ph.D. with Howard Chang developing methods to study RNA-protein interactions. From this work, he won the Weintraub Graduate Student Award. As a post-doc he changed fields to learn both chemistry and glycobiology with Carolyn Bertozzi at Stanford as a Damon Runyon Cancer Research Postdoctoral Fellow. At the beginning of 2021, the Flynn Lab opened at Boston Children’s Hospital in the Stem Cell Program and the Department of Stem Cell and Regenerative Biology at Harvard University. The Flynn Lab is currently focused on advancing methods and mechanisms surrounding the glycoRNA molecule, which operates at the interface of RNA biology and the secretory pathway.  

Lab Website: http://www.rafrna.com/ 

Twitter: @raflynn5  

 

Welcome to this exciting seminar!  

Ville Paavilainen 

 

Selected publications: 

Ryan A Flynn , Kayvon Pedram, Stacy A Malaker, Pedro J Batista, Benjamin A H Smith, Alex G Johnson, Benson M George, Karim Majzoub, Peter W Villalta, Jan E Carette, Carolyn R Bertozzi. Small RNAs are modified with N-glycans and displayed on the surface of living cells. Cell 2021 Jun 10;184(12):3109-3124.e22.doi: 10.1016/j.cell.2021.04.023.  

Ryan A Flynn, Julia A Belk, Yanyan Qi , Yuki Yasumoto, Jin Wei, Mia Madel Alfajaro, Quanming Shi, Maxwell R Mumbach, Aditi Limaye, Peter C DeWeirdt, Cameron O Schmitz, Kevin R Parker, Elizabeth Woo, Howard Y Chang, Tamas L Horvath, Jan E Carette, Carolyn R Bertozzi, Craig B Wilen, Ansuman T Satpathy. Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions. Cell 2021 Apr 29;184(9):2394-2411.e16. doi: 10.1016/j.cell.2021.03.012. 


Aloitusaika: 10.10.2022 13:00
Lopetusaika: 10.10.2022 14:00
Kesto: 1 hour
Sijainti: Biocenter 2, Lecture Hall 1041, Viikinkaari 5
Tyyppi: Seminar
Organisaatio: Helsinki Institute of Life Science HiLIFE
Yhteyshenkilö: hilife-seminars@helsinki.fi
lokakuu 11

KLIINISEN PATOLOGIAN NYKYNÄKYMIÄ

​FINPROVE
Katriina Peltola

Aloitusaika: 11.10.2022 12:15
Lopetusaika: 11.10.2022 13:00
Kesto: 45 minutes
Sijainti: Patologian kirjasto (C-porras, 2. krs), Haartmaninkatu 3, 00290 Helsinki
Tyyppi: Seminar
Organisaatio: UH, Faculty of Medicine
Yhteyshenkilö:
lokakuu 13

iCAN Science Seminar by Dr. Saar Gill

​CAR T cells for myeloid malignancies

Dr. Gill obtained his medical degree and Ph.D in immunology from the University of Melbourne, and trained in hematology at St Vincent’s Hospital, the Royal Melbourne Hospital and the Peter MacCallum Cancer Centre. In 2008 he moved to the United States, first to pursue a post-doctoral fellowship in cellular therapy at Stanford University, and then in 2011 to the University of Pennsylvania where he is now an associate professor of medicine. Dr. Gill’s clinical practice is in leukaemia and bone marrow transplantation. He has led clinical trials of chimeric antigen receptor (CAR) T cells for chronic and acute leukemias. Dr. Gill’s research laboratory focuses on the interface between adoptive cellular therapy and genetic engineering.

 

https://www.med.upenn.edu/cci/gilllab

 

If you would like to have a meeting with Dr. Gill, please contact Satu Mustjoki (satu.mustjoki@helsinki.fi) or Francesca De Lorenzo (francesca.delorenzo@helsinki.fi)

 

Recent publications:

 

Gill SI, Vides V, Frey NV, Hexner E, Metzger S, O'Brien M, Hwang WT, Brogdon JL, Davis MM, Fraietta JA, Gaymon A, Gladney WL, Lacey SF, Lamontagne A, Mato AR, Maus MV, Melenhorst JJ, Pequignot E, Ruella M, Shestov MA, Byrd JC, Schuster SJ, Siegel DL, Levine BL, June CH, Porter DL. Anti-CD19 CAR T Cells in Combination with Ibrutinib for the Treatment of Chronic Lymphocytic Leukemia. Blood Adv. 2022 Mar 29:bloodadvances.2022007317.

 

Singh N*, Frey NV*, Engels B*, Barrett DM, Shestova O, Ravikumar P, Cummins KD, Lee YG, Pajarillo R, Chun I, Shyu A, Highfill SL, Price A, Zhao L, Peng L, Granda B, Ramones M, Lu XM, Christian DA, Perazzelli J, Lacey SF, Roy NH, Burkhardt JK, Colomb F, Damra M, Abdel-Mohsen M, Liu T, Liu D, Standley DM, Young RM, Brogdon JL, Grupp SA, June CH, Maude SL*, Gill S*, Ruella M*. Antigen-independent activation enhances the efficacy of 4-1BB-costimulated CD22 CAR T cells. Nat Med. 2021 May;27(5):842-850. *equal contribution

 

Klichinsky M, Ruella M, Shestova O, Lu XM, Best A, Zeeman M, Schmierer M, Gabrusiewicz K, Anderson NR, Petty NE, Cummins KD, Shen F, Shan X, Veliz K, Blouch K, Yashiro-Ohtani Y, Kenderian SS, Kim MY, O'Connor RS, Wallace SR, Kozlowski MS, Marchione DM, Shestov M, Garcia BA, June CH, Gill S. Human chimeric antigen receptor macrophages for cancer immunotherapy. Nat Biotechnol. 2020 Aug;38(8):947-953.

 

Singh N*, Lee YG*, Shestova O, Ravikumar P, Hayer KE, Hong SJ, Lu XM, Pajarillo R, Agarwal S, Kuramitsu S, Orlando EJ, Mueller KT, Good CR, Berger SL, Shalem O, Weitzman MD, Frey NV, Maude SL, Grupp SA, June CH, Gill S*, Ruella M*. Impaired Death Receptor Signaling in Leukemia Causes Antigen-Independent Resistance by Inducing CAR T-cell Dysfunction. Cancer Discov. 2020 Apr;10(4):552-567. *equal contribution

 

Kim MY, Yu KR, Kenderian SS, Ruella M, Chen S, Shin TH, Aljanahi AA, Schreeder D, Klichinsky M, Shestova O, Kozlowski MS, Cummins KD, Shan X, Shestov M, Bagg A, Morrissette JJD, Sekhri P, Lazzarotto CR, Calvo KR, Kuhns DB, Donahue RE, Behbehani GK, Tsai SQ, Dunbar CE, Gill S. Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia. Cell. 2018 May 31;173(6):1439-1453.e19.


Aloitusaika: 13.10.2022 10:00
Lopetusaika: 13.10.2022 11:00
Kesto: 1 hour
Sijainti: Biomedicum1, lecture hall 2, Haartmaninkatu 8, 00290 Helsinki
Tyyppi: Seminar
Organisaatio: iCAN Flagship Team
Yhteyshenkilö: francesca.delorenzo@helsinki.fi
lokakuu 14

Dissertation: Saana Mönkäre

Saana Mönkäre, University of Helsinki, Faculty of Medicine, Doctoral Programme in Biomedicine
Genetics of inherited small vessel diseases

Opponent: docent Maria Johansson-Soller, Karolinska University Hospital



Aloitusaika: 14.10.2022 12:00
Lopetusaika: 14.10.2022 14:00
Kesto: 2 hours
Sijainti: University of Helsinki main building, Fabianinkatu 33, Helsinki
Tyyppi: Dissertation
Organisaatio: UH, Faculty of Medicine
Yhteyshenkilö: saana.monkare@helsinki.fi