Tapahtumakalenteri
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HiLIFE webinar / Biomedicum Helsinki seminar: Sara Zanivan
CAF metabolism drives pro-metastatic remodelling of the tumour microenvironment
Sara leads the Tumour Microenvironment & Proteomics lab and is head of the Advanced Technology Proteomics Facility at the Cancer Research UK Beatson Institute in Glasgow, and is Professor at the Institute of Cancer Sciences at the University of Glasgow. She graduated in Biology at the University of Torino and received her PhD degree in Complex Systems for Quantitative Biomedicine for work on cell-extracellular matrix adhesion at the Candiolo Cancer Institute in Torino, Italy. Before joining the Beatson, she was post-doc at the Max-Planck Institute for Biochemistry in Munich where she developed mass spectrometry-based proteomic technology to study cancer signalling in vivo and in 3D models. Her research aims to understand the molecular mechanisms through which cancer-associated fibroblasts (CAFs) alter the tumour microenvironment to influence cancer aggressiveness and resistance to therapy. CAF metabolism and their crosstalk signalling with other cell types are major research focus, and the overarching goal of her research is to find ways to target CAFs in combination with other anti-cancer therapies to improve survival of cancer patients. Sara’s group also develops mass spectrometry proteomic approaches, including new methods to study cell metabolism in vitro and in vivo, at cellular and systemic level.
Sara leads the Tumour Microenvironment & Proteomics lab and is head of the Advanced Technology Proteomics Facility at the Cancer Research UK Beatson Institute in Glasgow, and is Professor at the Institute of Cancer Sciences at the University of Glasgow. She graduated in Biology at the University of Torino and received her PhD degree in Complex Systems for Quantitative Biomedicine for work on cell-extracellular matrix adhesion at the Candiolo Cancer Institute in Torino, Italy. Before joining the Beatson, she was post-doc at the Max-Planck Institute for Biochemistry in Munich where she developed mass spectrometry-based proteomic technology to study cancer signalling in vivo and in 3D models. Her research aims to understand the molecular mechanisms through which cancer-associated fibroblasts (CAFs) alter the tumour microenvironment to influence cancer aggressiveness and resistance to therapy. CAF metabolism and their crosstalk signalling with other cell types are major research focus, and the overarching goal of her research is to find ways to target CAFs in combination with other anti-cancer therapies to improve survival of cancer patients. Sara’s group also develops mass spectrometry proteomic approaches, including new methods to study cell metabolism in vitro and in vivo, at cellular and systemic level.
Zanivan Research Group
@ZanivanLab
Welcome to this exciting seminar!
Elina Pietilä
Selected publications
Emily J Kay, Karla Paterson, David Sumpton, Ekaterina Stepanova, Claudia Boldrini, Juan R Hernandez-Fernaud, Sandeep Dhayade, Enio Gjerga, Robin Shaw, Lisa J Neilson, Grigorios Koulouras, Grace McGregor, Sergio Lilla, Craig Jamieson, Ann Hedley, Radia Marie Johnson, Morag Park, Crispin Miller, Jurre J Kamphorst, Fabricio Loayza-Puch, Julio Saez-Rodriguez, Karen Blyth, Michele Zagnoni, Sara Zanivan. Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix. Accepted Nature Metabolism 2022. BioRxiv https://doi.org/10.1101/2020.05.30.125237
Kugeratski FG, Atkinson SJ, Neilson LJ, Lilla S, Knight JRP, Serneels J, Juin A, Ismail S, Bryant DM, Markert EK, Machesky LM, Mazzone M, Sansom OJ, and Zanivan S. Hypoxic cancer–associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling. Science Signaling 2019 12(567), eaan8247. Cover Story. Editor’s choice in Science Signaling 12(569), eaax0155.
van der Reest J , Lilla S, Zheng L*, Zanivan S* and Gottlieb E*. Proteome-wide analysis of cysteine oxidation reveals metabolic sensitivity to redox stress. Nat Commun. 2018 9(1):1581. *Corresponding author.
Reid SE, Kay EJ, Neilson LJ, Henze AT, Serneels J, McGhee EJ, Dhayade S, Nixon C, Mackey JB, Santi A, Swaminathan K, Athineos D, Papalazarou V, Patella F, Román-Fernández Á, ElMaghloob Y, Hernandez-Fernaud JR, Adams RH, Ismail S, Bryant DM, Salmeron-Sanchez M, Machesky LM, Carlin LM, Blyth K, Mazzone M, Zanivan S. Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium. EMBO J. 2017 36(16):2373-2389.
Hernandez-Fernaud JR, Ruengeler E, Casazza A, Neilson LJ, Pulleine E, Santi A, Ismail S, Lilla S, Dhayade S, Macpherson IR, McNeish I, Ennis D, Ali H, Kugeratski F, Al Khamici H, van den Biggelaar M, van den Berghe PVE, Cloix C, McDonald L, Millan D, Hoyle A, Kuchnio A, Carmeliet P, Valenzuela SM, Blyth K, Yin H, Mazzone M, Norman JC and Zanivan S. Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity. Nat Commun. 2017 8:14206.
Aloitusaika: 29.04.2022 10:00
Lopetusaika: 29.04.2022 11:00
Kesto: 1 hour
Sijainti: Biomedicum1, lecture hall 1, Haartmaninkatu 8, 00290 Helsinki
Tyyppi: Seminar
Organisaatio: Biomedicum Helsinki
Yhteyshenkilö: hilife-seminars@helsinki.fi
Online-kokouslinkki:
https://helsinki.zoom.us/j/69292028293
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Dissertation: Kristiina Pynnä
Kristiina Pynnä, University of Helsinki, Faculty of Medicine, Doctoral Program in Clinical Research
HEALTH-RELATED QUALITY OF LIFE AND COST OUTCOMES OF TREATMENT OF GYNECOLOGICAL CONDITIONS
Opponent: professor Terhi Piltonen, University of Oulu
Aloitusaika: 29.04.2022 12:00
Lopetusaika: 29.04.2022 14:00
Kesto: 2 hours
Sijainti: Naistenklinikka, Seth Wichmann -sali, Haartmaninkatu 2
Tyyppi: Dissertation
Organisaatio: UH, Faculty of Medicine
Yhteyshenkilö: kristiina.pynna@hus.fi
Lisätiedot:
https://helda.helsinki.fi/handle/10138/341723
Online-kokouslinkki:
https://helsinki.zoom.us/j/61303892934?pwd=Y3lBL0F1V1hKR2huR0h2a2xITDcyUT09
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Dissertation: Juuso Rusanen
Juuso Rusanen, University of Heslinki, Faculty of Medicine, Doctoral Programme in Biomedicine
New Applications for TR-FRET-based Homogeneous Immunoassays in Diagnosis of Infectious and Autoimmune Diseases
Opponent: Associate professor Susanne Dudman, University of OsloAloitusaika: 29.04.2022 13:00
Lopetusaika: 29.04.2022 15:00
Kesto: 2 hours
Sijainti: Haartman Institute, lecture hall 2, Haartmaninkatu 3, 00290 Helsinki
Tyyppi: Dissertation
Organisaatio: UH, Faculty of Medicine
Yhteyshenkilö: juuso.rusanen@helsinki.fi
Lisätiedot:
https://helda.helsinki.fi/handle/10138/342520
Online-kokouslinkki:
https://video.helsinki.fi/unitube/live-stream.html?room=l11
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Dissertation: Elina Pietilä
Elina Pietilä, University of Helsinki, Faculty of Medicine, Doctoral Programme in Integrative Life Science
Cancer cell-microenvironment communication in tumor progression and therapy resistance
Opponent: professor Sara Zanivan, University of GlasgowAloitusaika: 29.04.2022 13:00
Lopetusaika: 29.04.2022 15:00
Kesto: 2 hours
Sijainti: Ossiansali, Topeliuksenkatu 20
Tyyppi: Dissertation
Organisaatio: UH, Faculty of Medicine
Yhteyshenkilö: elina.a.pietila@helsinki.fi
Lisätiedot:
https://helda.helsinki.fi/handle/10138/342586
Online-kokouslinkki:
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Dissertation: Ella Kohva
Ella Kohva, University of Helsinki, Faculty of Medicine, Doctoral Program in Clinical ResearchDevelopment of fertility potential and treatment modalities in differences of sex development and delayed puberty
Opponent: professor S. Faisal Ahmed, School of Medicine, Dentistry and Nursing; College of Medical, Veterinary and Life Sciences; University of Glasgow, UK
Aloitusaika: 29.04.2022 13:00
Lopetusaika: 29.04.2022 15:00
Kesto: 2 hours
Sijainti: Biomedicum1, lecture hall 2, Haartmaninkatu 8, 00290 Helsinki
Tyyppi: Dissertation
Organisaatio: UH, Faculty of Medicine
Yhteyshenkilö: ella.kohva@gmail.com
Lisätiedot:
https://helda.helsinki.fi/handle/10138/342547
Online-kokouslinkki:
https://video.helsinki.fi/unitube/live-stream.html?room=l43