Tapahtumakalenteri (vanha)
Dissertation: Marjut Metsäniitty
Opponent: Professor Margaret Sällberg Chen, Karolinska Institute
Dissertation: Iiris Nyholm
Opponent: docent Fredrik Åberg, University of Helsinki
Dissertatiin: Pi Fagerlund
HiLIFE / Biomedicum Helsinki seminar by Bogdan Pasaniuc:
Dr Pasaniuc is an professor of Computational Medicine, Human Genetics and Pathology & Laboratory Medicine at UCLA. Dr Pasaniuc develops statistical and computational methods to understand the genetic basis of disease, focusing on under-represented populations, integrative genomics, and biobank studies. Dr Pasaniuc group developed machine learning methods to integrate epigenetic profiles within trans-ancestry studies to localize disease variants and genes; his group introduced transcriptome-wide association studies (TWAS) using predicted gene expression as a principled approach to identify disease genes for many traits such as Schizophrenia, Ovarian Cancer and Prostate Cancer. Dr Pasaniuc serves as Associate Director of Population Genetics of the Institute for Precision Health at UCLA that links the genetics of more than 150k patients with their electronic health record to predict health outcomes, to stratify patients based on their genetic risk to disease and to translate genomics to the clinic. Dr Pasaniuc also serves as PI for the Center for Admixed populations and Health Equity and for the Biomedical Data Science Training Program for Precision Health Equity at UCLA.
Welcome to this exciting seminar!
Andrea Ganna
Selected publications
Polygenic scoring accuracy varies across the genetic ancestry continuum. Ding et al. Nature. 2023.
Large uncertainty in individual polygenic risk score estimation impacts PRS-based risk stratification. Ding*, Hou*, et al. Nat Genet. 2022.
Impact of cross-ancestry genetic architecture on GWASs in admixed populations. Mester et al. AJHG. 2023.
Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals. Hou et al. Nat Genet. 2023.
Special semnar by Prof Gyorgy Hajnóczky
Gyorgy Hajnóczky: Mitochondrial form and
function in the brain
Prof Gyorgy Hajnóczky from the Department of Pathology and Cell
Biology, Thomas Jefferson University, Philadelphia, is the Founding Director of
the MitoCare Center for Mitochondrial Imaging Research and Diagnostics.
Hajnóczky group was among the first to visualize mitochondrial energy and ion
metabolism in single live cells. They are credited with the discovery of
physically tethered contact sites between endoplasmic reticulum (ER)
and mitochondria, and that the ER-mitochondrial “synapses” enable calcium
signal propagation to the mitochondria to control both energy
production and cell death. They have also had major contributions to the
current understanding of mitochondrial maintenance and proper distribution by
fusion and movement. Hajnóczky group has invented numerous microscopy
techniques and probes to benefit the field. Their major
current focus is on the role of dysregulation of mitochondrial calcium
homeostasis, energetics and dynamics in human neuropathogenesis. For a meeting with Prof Hajnóczky, please
contact henna.tyynismaa@helsinki.fi. EXAMPLES OF RECENT PUBLICATIONS: Gal A, Balicza P, Weaver D, Naghdi S, Joseph SK, Várnai P, Gyuris
T, Horváth A, Nagy L, Seifert EL, Molnar MJ, Hajnóczky G. EMBO Mol
Med. 2023 Aug 7;15(8):e17911. doi: 10.15252/emmm.202317911. MICU1 controls the sensitivity of the mitochondrial
Ca2+ uniporter to activators and inhibitors. Rodríguez-Prados M, Huang KT, Márta K, Paillard M, Csordás G,
Joseph SK, Hajnóczky G. Cell Chem Biol. 2023 Jun
15;30(6):606-617.e4. doi: 10.1016/j.chembiol.2023.05.002. Fuel oxidation under the control of mitochondrial shape and
dynamics. Seifert EL, Hajnóczky G. EMBO J. 2023 Jun
1;42(11):e114129. doi: 10.15252/embj.2023114129. Katona M, Bartók Á, Nichtova Z, Csordás G, Berezhnaya E, Weaver D,
Ghosh A, Várnai P, Yule DI, Hajnóczky G. Nat Commun. 2022 Nov
9;13(1):6779. doi: 10.1038/s41467-022-34365-8. Singh R, Bartok A, Paillard M, Tyburski A, Elliott M, Hajnóczky
G. Sci Adv. 2022 Mar 18;8(11):eabj4716. doi: 10.1126/sciadv.abj4716. Oxidative bursts of single mitochondria mediate retrograde
signaling toward the ER. Booth DM, Várnai P, Joseph SK, Hajnóczky G. Mol Cell.
2021 Sep 16;81(18):3866-3876.e2. doi: 10.1016/j.molcel.2021.07.014. IP3 receptor isoforms differently regulate
ER-mitochondrial contacts and local calcium transfer. Bartok A, Weaver D, Golenár T, Nichtova Z, Katona M, Bánsághi S,
Alzayady KJ, Thomas VK, Ando H, Mikoshiba K, Joseph SK, Yule DI, Csordás G, Hajnóczky
G. Nat Commun. 2019 Aug 19;10(1):3726. doi:
10.1038/s41467-019-11646-3. Best regards, Henna Tyynismaa & Emil Ylikallio