toukokuu 24

CancerBio Summer School Special Seminar: Mikaela Ekgblad

Heroes and villains: Immune cells regulating metastasis

Professor Mikala Egeblad obtained degrees in Medicine (B.S., 1993). Human Biology (M.Sc., 1996), and in Cancer Biology (Ph.D., 2000) from the University of Copenhagen, Denmark. She did her dissertation research under the mentorship of Dr. Marja Jäättelä at The Danish Cancer Society. Her postdoctoral training was performed in the laboratory of Dr. Zena Werb at University of California, San Francisco. There, she began developing intravital spinning disk confocal microscopy to understand how the microenvironment influences tumor progression, focusing on innate immune cell responses and protease-mediated extracellular matrix remodeling. She came to Cold Spring Harbor Laboratory in 2009 and established a research group that studies how the tumor microenvironment contributes to therapy resistance and metastasis, primarily focusing on the role of inflammatory cells. In 2014, she was promoted to Associate Professor and in January 2021 to Professor.

Selected publications:

Sun, L., Kees, T., Almeida, A. S., Liu, B., ... and Egeblad, M. (2020). Activating a collaborative innate-adaptive immune response to control breast and ovarian cancer metastasis. bioRxiv, 2020/200477; https://doi.org/10.1101/2020.07.13.200477

Fein, M. R., He, X. Y., Almeida, A. S., Bruzas, E., ... and Egeblad, M. (2020). Cancer cell CCR2 orchestrates suppression of the adaptive immune response. Journal of Experimental Medicine. https://doi.org/10.1084/JEM.20181551  

Middleton, EA, He, X.-Y., Denorme, F, Campbell, RA, … and Egeblad, M., Schiffman, JD., Con Yost, C. (2020). Neutrophil Extracellular Traps (NETs) Contribute to Immunothrombosis in COVID-19 Acute Respiratory Distress Syndrome. Blood. https://doi.org/10.1182/blood.2020007008

Barnes, B. J., Adrover, J. M., Baxter-Stoltzfus, A., Borczuk, A., … and Egeblad, M. (2020). Targeting potential drivers of COVID-19: Neutrophil extracellular traps. In Journal of Experimental Medicine. https://doi.org/10.1084/jem.20200652

Albrengues, J., Shields, M. A., Ng, D., Park, C. G., Ambrico, A., … and Egeblad, M. (2018). Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice. Science. https://doi.org/10.1126/science.aao4227

Park, J., Wysocki, R. W., Amoozgar, Z., Maiorino, L., ... and Egeblad, M. (2016). Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps. Science Translational Medicine. https://doi.org/10.1126/scitranslmed.aag1711

Find below more information on Professor Egeblad’s research and recent publications:

We welcome you to this exciting seminar.
CancerBio Summer School organizing team

Juha Klefström, Jeroen Pouwels,
Mariel Savelius, Krista Tuohinto,
Dipabarna Bhattacharya & Anna Laury

Aloitusaika: 24.05.2021 15:00
Lopetusaika: 24.05.2021 16:00
Sijainti: remotely
Tyyppi: Webinar
Organisaatio: CancerBio Summer School
Yhteyshenkilö: mariel.savelius@helsinki.fi>
kesäkuu 08

10th Meeting on Complement-related diseases: Blood, Brain & Kidneys

Chair: Seppo Meri

13:00 Welcome Seppo Meri, Helsinki
13:05 Overview on complement and complement diagnostics
 Sakari Jokiranta, Helsinki
13:25 The immunology of ALS and NMOSD Pentti Tienari, Helsinki 

13.55 Antibody-dependent neural damage in NMOSD, Mikael Simons, Munich
Coffee Break 14:30-15:15
Chair: Sakari Jokiranta
15.15 Covid-19 and the brain Liisa Myllykangas, Helsinki

15.45 C3 glomerulopathy Kati Kaartinen, Helsinki
16:15 Questions and discussion Seppo Meri, Sakari Jokiranta

17.00       End of meeting
Registration no later than May 31, 2021 to:

Aloitusaika: 08.06.2021 13:00
Lopetusaika: 08.06.2021 17:00
Kesto: 4 hours
Sijainti: The National Museum of Finland Auditorium, Mannerheimintie 34, Helsinki
Tyyppi: Meeting
Organisaatio: UH, Faculty of Medicine
Yhteyshenkilö: liisa.penttila@helsinki.fi
elokuu 19

Symposium: Cancer - Breaking Bad

​30th BioCity Symposium-14th Finnish Cancer Insitute Symposium
Depending on the pandemics situation, the Symposium will be arranged either as a hybrid or as a fully virtual event

Aloitusaika: 19.08.2021 09:00
Lopetusaika: 20.08.2021 18:00
Kesto: 33 hours
Sijainti: Mauno Conference Center, BioCity Turku
Tyyppi: Symposium
Organisaatio: Finnish Cancer Institute
Yhteyshenkilö: tiina.vesterinen@helsinki.fi