Tapahtumakalenteri
Dissertation: Pauliina Repo
Opponent: Professor Sapna Patel, Medicine-Medical Oncology, University of Colorado Cancer Center, USA
Kliinisen mikrobiologian perjantaisarja
Hanna Liimatainen, bioinformaatikko, kliininen
Dissertation: Phuoc Truong Nguyen
Opponent: Professor Samantha Lycett, University of Edinburgh
Seminar: by Prof. Antal Rot, chemokine signalling and tumorigenesis
A warm welcome to the seminar “New Functional Facets of Classical and Atypical Chemokine Receptors” by Prof. Antal Rot (Queen Mary University of London) on Tuesday the 27th of May at 15:00-16:00 in Biomedicum seminar room 1-2.
The seminar is organized by Translational Cancer Medicine Research Program (CAN-PRO). On Wednesday the 28th of May, Prof. Rot will act as an opponent in a Ph.D. thesis defense of M.Sc. Inam Liaqat.
Chemokines play a pivotal role in controlling, for example, leukocyte mediated antigen trafficking, T cell activation and, also, tumor dissemination. Prof. Rot is one of the leading figures on the chemokine research field. He acted 20 years as the Head of Experimental Pathology at Novartis (Vienna). After Institute’s closure, Antal moved to the UK taking up successive professorial appointments at the Universities of Birmingham and York. Since 2017 Antal has worked at the London School of Medicine, Queen Mary University of London.
Prof. Rot will present unpublished studies revealing an unexpected physiological phenomenon of chemokine receptor signalling from the nucleus and new findings on how erythroid ACKR1 modifies chemokine involvement in prostate cancer.
Selected Publications:
- Atypical chemokine receptor 1 on nucleated erythroid cells regulates haematopoiesis. Duchene J, Novitzky-Basso I, Thiriot A, Casanova-Acebes M, Bianchini M, Etheridge SL, Hub E, Nitz K, Artinger K, Eller K, Caamaño J, Rülicke T, Moss P, Megens RTA, von Andrian UH, Hidalgo A, Weber C, Rot A. Nat Immunol 18:753-761, 2017
- Atypical chemokine receptor CCRL1 shapes functional CCL21 gradients in lymph nodes. Ulvmar MH, Braun A, Werth K, Kelay P, Hub E, Eller K, Lucas B, Nakamura K, Chan L, Novitzky-Basso I, Rülicke T, Nibbs RJB, Worbs T, Forster R and Rot A. Nat Immunol 15:623-30, 2014
- Duffy antigen/receptor for chemokines transports chemokines and supports their pro-migratory activity. Pruenster M, Mudde-Boer L, Bombosi P, Zsak M, Dimitrova S, Middleton J, Richmond A, Graham GJ, Segerer S, Nibbs RJ and Rot A. Nat Immunol 10:101-8, 2009