Tapahtumakalenteri

huhtikuu 10

FICAN science webinar

Topic: Unveiling the immune landscape of colorectal cancer through quantitative, spatially resolved techniques
Speaker: Juha Väyrynen, MD, PhD, Adjunct professor in Cancer Biology, University of Oulu and Oulu University Hospital

This time the seminar is organized by FICAN North. The seminar will be held online (Microsoft Teams) at 15:00-16:00 and is open to everyone interested in cancer research:

Abstract:
Recent advances in cancer immunology have led to new cancer therapies activating anti-tumor immune responses. Studies have revealed that high lymphocyte densities are associated with favorable outcome in colorectal cancer, and the Immunoscore (IS), which measures CD3+ and
CD8+ T-cell densities, is an independent prognostic factor in colon cancer, surpassing the traditional TNM (tumor-node-metastasis) classification. However, the IS only considers cell densities and overlooks the spatial localization of immune and tumor cells.
 
The immune system can also aid tumor growth by supporting cell proliferation and angiogenesis and dampening anti-tumor immunity. Immature myeloid immune cells can be abnormally produced in cancer, leading to myeloid-derived suppressor cell (MDSC) accumulation.
Besides MDSCs, mature myeloid cells like macrophages are prevalent in the tumor microenvironment and affect tumor progression. Their role is complex, with a range of pro- and anti-inflammatory states, needing multi-marker approaches for accurate assessment.
 
We have utilized supervised machine learning based image analysis combined with hematoxylin-eosin staining or multiplex immunohistochemistry to recognize various immune cell populations in the colorectal cancer microenvironment. We have utilized spatial analysis methods to characterize the spatial patterns of immune cell infiltrates. Our results have identified several prognostically favorable (such as T cells, M1-like macrophages, mature monocytic cells, eosinophils) and unfavorable (such as M2-like macrophages and immature monocytic cells) cell types and shown that spatial immune features also harbor prognostic relevance. Our findings pave the way for developing advanced tumor-immune biomarkers for precision medicine.

Aloitusaika: 10.04.2024 15:00
Lopetusaika: 10.04.2024 16:00
Kesto:
Sijainti: remotely
Tyyppi: Webinar
Organisaatio: Finnish Cancer Center (FICAN)
Yhteyshenkilö: tuula.kallioinen@hus.fi
huhtikuu 11

Metabolism seminar

Marja Mikkola, Growth and patterning in the developing mammary gland

Qiang Lan, Growth control in the embryonic mammary gland

 

Takashi Namba, Matilde Aquilino and Vasiliki Gkini
Neural stem cell metabolism: from brain evolution to diseases

Credits for studentsILS-008  

  

Please spread the word to your group members and others that might be interested. 
Stem cell seminars also has an own e-mail list. Please contact Emilia if you would like to be included on it. 


Aloitusaika: 11.04.2024 09:00
Lopetusaika: 11.04.2024 11:00
Kesto: 2 hours
Sijainti: Biomedicum 1, seminar room 3
Tyyppi: Seminar
Organisaatio: University of Helsinki
Yhteyshenkilö: emilia.kuuluvainen@helsinki.fi
huhtikuu 17

Drug safety during pregnancy and lactation - 30 years of teratology information service in Finland

Finnish Teratology Information Service was established 30 years ago. To celebrate our journey, we will organize together with Finnish Society of Clinical Pharmacology and University of Helsinki 30th Anniversary Symposium ”Drug safety during pregnancy and lactation - 30 years of teratology information service in Finland” on 17th of April 2024 at Biomedicum, Helsinki.

 

Participation to Symposium is free of charge. Scientific programme will include presentations on drug utilization during pregnancy and breastfeeding, potential drug effects on fetal and neonatal health, and how to use secondary data and to apply new statistical methods in pharmacovigilance studies. Full programme is available here.

 

Symposium is open for all health care professionals but primarily targeted for clinicians caring for people and families who are planning a pregnancy or already are pregnant or breastfeeding.

 

We have applied 4 hours of theoretical training in the KOPI system for following specialties: Obstetrics and Gynaecology, Clinical Pharmacology and Pharmacotherapy, General Practice, Paediatrics, Public Health. There will be a possibility for online participation to those living outside the capital region. Kindly note that the certificate of attendance will only be provided to participants on site at Biomedicum.

 

Register yourself on Wednesday 3rd of April at the latest using the registration form. Online participants will receive a link to webinar 1-2 days before the Symposium to the email address they have provided at the registration form. In case you will need to cancel your participation after the registration, please fill out and submit a separate cancellation form as soon as possible so that we can arrange enough coffee and tea on site.

 

You are warmly welcome to join to celebrate our 30th Anniversary!


Aloitusaika: 17.04.2024 12:00
Lopetusaika: 17.04.2024 16:00
Kesto: 3 hours
Sijainti: Biomedicum1, lecture hall 2, Haartmaninkatu 8, 00290 Helsinki
Tyyppi: Symposium
Organisaatio: HUS
Yhteyshenkilö: petri.makela@helsinki.fi
huhtikuu 26

ONCOSYS Special seminar

Speaker: Simone Zaccaria

Tentative title: “Measuring the proliferation rates of single-cell tumour clones though cancer and metastatic evolution.”

Recent publications:

Myers et al. HATCHet2: clone- and haplotype-specific copy number inference from bulk tumor sequencing data. Preprint 2023.

Frankell et al. The evolution of lung cancer and impact of subclonal selection in TRACERx. Nature 2023.

Grigoriadis et al. CONIPHER: a computational framework for scalable phylogenetic reconstruction with error correction. Nature Protocols 2023.

Zaccaria & Raphael. Accurate quantification of copy-number aberrations and whole-genome duplications in multi-sample tumor sequencing data. Nature Communications 2020.

Pich et al. The translational challenges of precision oncology. Cancer Cell 2022.



Aloitusaika: 26.04.2024 10:00
Lopetusaika: 26.04.2024 11:00
Kesto: 1 hour
Sijainti: Biomedicum 1, seminar room 3
Tyyppi: Seminar
Organisaatio: UH, Faculty of Medicine
Yhteyshenkilö: karen.ahlnas@helsinki.fi