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November 29

Dissertation: Kirsi-Maaria Nyrhinen

Kirsi-Maaria Nyrhinen, University of Helsinki, Faculty of Medicine, Doctoral Program in Clinical Research
Comparison of two drilling techniques in ACL reconstruction, outcomes of surgically treated PCL injuries and patient injury claims following cruciate ligament injury treatment in Finland

Opponent: docent Heidi Haapasalo, University of Tampere



Start time: 29/11/2024 12:00
End time: 29/11/2024 14:00
Duration: 2 hours
Location: HUS SIltasairaala, Töölö luentosali STB3.03, Haartmaninkatu 4
Type: Dissertation
Organization: UH, Faculty of Medicine
Contact person: kirsi.maaria.nyrhinen@gmail.com
Further information: https://helda.helsinki.fi/items/ce848c0a-941d-4271-aa96-a07292a1b134
Online meeting link: https://teams.microsoft.com/l/meetup-join/19%3ameeting_ZjgyNGE1ZTItYWViOS00YmEyLWE4NTctNTNhMWUzNmJkMmNj%40thread.v2/0?context=%7b%22Tid%22%3a%22e307563d-5fcd-4e12-a554-9927f388b1cf%22%2c%22Oid%22%3a%2282e60a22-c4a0-4cdb-8551-48b0177940d0%22%7d
November 29

Dissertation: Laura Peräkylä

Laura Peräkylä, University of Helsinki, Faculty of Medicine, Doctoral Program in Clinical Research
Chronic lung allograft dysfunction : impact on prognosis and analysis using computed tomography

Opponent: professor Are Holm, University of Oslo



Start time: 29/11/2024 12:00
End time: 29/11/2024 14:00
Duration: 2 hours
Location: Biomedicum1, lecture hall 3, Haartmaninkatu 8, 00290 Helsinki
Type: Dissertation
Organization: UH, Faculty of Medicine
Contact person: laura.perakyla@gmail.com
Further information: https://helda.helsinki.fi/items/cf5210ba-03b1-4506-aec1-8aa5fde4c8fc
Online meeting link:
November 29

Dissertation: Mirjami Tran Minh

Mirjami Tran Minh, University of Helsinki, Faculty of Medicine, Doctoral Program in Population Health
Potilasjärjestöjen lausunnot lääkkeiden hintalautakunnalle ja terveydenhuollon palveluvalikoimaneuvostolle : Kokemuksia lääkeaiheisten lausuntojen antamisesta, osallisuudesta ja lausuntojen merkityksestä

Opponent: Professor (tenure track) Jari Kylmä, University of Tampere



Start time: 29/11/2024 13:00
End time: 29/11/2024 15:00
Duration: 2 hours
Location: Haartman Institute, lecture hall 2, Haartmaninkatu 3, 00290 Helsinki
Type: Dissertation
Organization: UH, Faculty of Medicine
Contact person: mirjami.tran@helsinki.fi
Further information: https://helda.helsinki.fi/items/97d456b1-3a8e-4412-a30c-1b8536dad02e
Online meeting link: https://video.helsinki.fi/unitube/live-stream.html?room=l11
November 29

Join to discuss image manipulations in the next ReproducibiliTea meeting!

Welcome to discuss the interesting topic of image manipulations!


Will you be able to spot the manipulations? What drives people to manipulate images?

Join our second  ReproducibiliTea journal club to discuss these themes and test in practice if you can spot the manipulations. We are offering tea and pulla and would like to know if you plan to join. The registration is not binding but helps us to plan the amount of snacks. Please let us know by November 25th but still come over even if you are late for the registration!  https://elomake.helsinki.fi/lomakkeet/132257/lomakkeet.html 

What? Our second ReproducibiliTea journal club where we will discuss the theme of image manipulation with a practical approach. Our example article will be "hnRNP K: An HDM2 Target and Transcriptional Coactivator of p53 in Response to DNA Damag, Moumen et al. 2016".  Link to The article PDF version  or copy to browser https://drive.google.com/file/d/1vTpB8wmkDS1d7Ud7M-XamVJTyCYK3ytW/view


Start time: 29/11/2024 14:00
End time: 29/11/2024 16:00
Duration: 1 hour
Location: Biomedicum Helsinki 1, meeting room Skutsi
Type: Other
Organization: UH, Faculty of Medicine
Contact person: julia.koivula@helsinki.fi
Further information: https://reproducibilitea.org/
Online meeting link:
December 02

HiLIFE / Biomedicum Helsinki seminar by Taija Mäkinen: Lymphatic vessels in tissue homeostasis and disease – insights from microscopic and transcriptional decoding at the single cell level

Lymphatic vessels in tissue homeostasis and disease – insights from microscopic and transcriptional decoding at the single cell level
Taija Mäkinen’s research focuses on the mechanisms regulating the lymphatic vascular system, which is increasingly recognized for its multifaceted roles and broad pathological relevance. By investigating the fundamental processes governing the developmental growth of lymphatic vasculature, her research has identified key regulators with implications for genetic human diseases and potential therapeutic targets. Additionally, her research explores the role of lymphatic vessels as organ-specific paracrine regulators of tissue homeostasis and disease processes. Recent advancements in her lab include the use of longitudinal intravital imaging to study homeostatic and disease mechanisms, as well as therapy responses, in mouse models of vascular disease (accepted in Nature).

Taija Mäkinen is currently a Professor at the Faculty of Medicine of the University of Helsinki, and Uppsala University, Sweden, and serves as the Director of the Wihuri Research Institute in Biomedicum Helsinki.

Welcome to this exciting seminar!
Pipsa Saharinen

Selected publications
Petkova M, Kraft M, Stritt S, Martinez-Corral I, Ortsäter H, Vanlandewijck M, Jakic B, Baselga E, Castillo SD, Graupera M, Betsholtz C, Mäkinen T. Immune-interacting lymphatic endothelial subtype at capillary terminals drives lymphatic malformation. J Exp Med Apr 3;220(4):e20220741. doi: 10.1084/jem.20220741 (2023).

Hernández Vásquez MN, Ulvmar MH, González-Loyola A, Kritikos I, Sun Y, He L, Halin C, Petrova TV, Mäkinen T. Transcription factor FOXP2 is a flow-induced regulator of collecting lymphatic vessels. EMBO J 40(12):e107192. doi: 10.15252/embj.2020107192 (2021).

Martinez-Corral I, Zhang Y, Petkova M, Ortsäter H, Sjöberg S, Diez SC, Brouillard P, Libbrecht L, Graupera M, Alitalo K, Boon L, Vikkula M, Mäkinen T. Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation. Nat Commun 11:2869 doi: 10.1038/s41467-020-16496-y (2020).

Frye M, Taddei A, Dierkes C, Martinez-Corral I, Fielden M, Ortsäter H, Kazenwadel J, Calado DP, Ostergaard P, Salminen M, He L, Harvey N, Kiefer F, Mäkinen T. Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program. Nat Commun, 9:1511 doi: 10.1038/s41467-018-03959-6 (2018).

Zhang Y, Ulvmar MH, Stanczuk L, Martinez-Corral I, Frye M, Alitalo, K, Mäkinen T. Heterogeneity in VEGFR3 levels drives lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms. Nat Commun 9:1296. doi: 10.1038/s41467-018-03692-0 (2018).

Start time: 02/12/2024 14:15
End time: 02/12/2024 15:15
Duration:
Location: Biomedicum1, lecture hall 1, Haartmaninkatu 8, 00290 Helsinki
Type: Seminar
Organization: Helsinki Institute of Life Science HiLIFE
Contact person: hilife-seminars@helsinki.fi
Further information: https://www.helsinki.fi/en/hilife-helsinki-institute-life-science/research/hilife-life-science-seminars/hilife-webinars
Online meeting link: https://helsinki.zoom.us/j/61892612947