Events

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September 13

iCAN science seminar: Tero Aittokallio

 Predictive modelling of drug combination effects for precision oncology.

Come early for a cup of coffee and discussions. Here's the link for those of you who wish to participate online:

Start time: 13/09/2023 12:00
End time: 13/09/2023 13:00
Duration:
Location: Biomedicum 1, seminar room 3
Type: Seminar
Organization: iCAN Flagship Team
Contact person: ican@helsinki.fi
Further information:
Online meeting link: https://helsinki.zoom.us/j/64804986682?pwd=ME8rOVhucnQ5YXE1VVdpck5BN25BZz09
September 13

Biostatistics drop-in workshop

​Are you a researcher needing support with any statistical aspect of your work? The Biostatistics Consulting Service here at Meilahti Campus holds drop-in workshop sessions every other week to answer smaller questions about your analysis - solving a particular problem, how to get started, etc. We provide service in Finnish, English and Swedish.

 

The next workshop is on Wednesday 13th September, at 13:00-15:00 in Biomedicum 2B, in the Olohuone on floor 6. Come whenever you can. Note that you may end up waiting a while for your turn, especially early on in the session. We aim to spend no more than 15 minutes with each customer.

 

Bring: 

·       your computer

·       your data

·       your questions

and we biostatisticians will be on hand to help and guide. 

 

Registration is not required, but you can help us prepare for your questions by filling in this form. The workshops are open to any researcher at the university's Medical Faculty, HUS or FIMM. 

The autumn's following sessions are planned for 27.9, 11.10, 25.10, 8.11, 22.11 & 13.12 (not 6.12!).

For more in-depth questions, please book a one-on-one consultation session using this e-form where we will have time to go into more detail. 

 

From the Biostatistics Team

 


Start time: 13/09/2023 13:00
End time: 13/09/2023 15:00
Duration: 2 hours
Location: Biomedicum 2, 6th floor lounge
Type: Other
Organization: Biostatistics Consulting Service
Contact person: biostat-consult@helsinki.fi
Further information: https://www.helsinki.fi/en/infrastructures/biostatistics-unit/consulting
Online meeting link:
September 13

Pharmacology Seminars: Timo Myöhänen

​Prolyl oligopeptidase as a drug target – past, present and future
Timo Myöhänen, Department of Pharmacology, UH/University of Eastern Finland

Start time: 13/09/2023 14:00
End time: 13/09/2023 14:45
Duration: 45 minutes
Location: Biomedicum 1, seminar room B201a
Type: Seminar
Organization: UH, Faculty of Medicine
Contact person: anni-maija.linden@helsinki.fi
Further information:
Online meeting link:
September 13

FICAN seminar Sampsa Hautaniemi

​​Characterizing and overcoming chemotherapy resistance mechanisms in ovarian cancer
Sampsa Hautaniemi
DTech, Professor of Systems Biology, Director, Research Program in Systems Oncology (ONCOSYS) & EU Horizon, 2020 consortium DECIDER
Faculty of Medicine, University of Helsinki
Chemotherapy resistance is one of the greatest contributors to cancer mortality. A prime example of the impact of our current inability to overcome treatment resistance is seen in ovarian high grade serous carcinoma (HGSC), which is the most common subtype of epithelial ovarian cancer. While 90% of HGSC patients show no clinically detectable signs of cancer after surgery and chemotherapy, tumors become progressively resistant to chemotherapy leading to five-year survival of <40%. We have established a prospective, longitudinal, multiregion observational study DECIDER (ClinicalTrials.gov identifier
NCT04846933) to characterize and overcome chemotherapy resistance in HGSC. In this presentation, I will discuss our latest ffindings on chemotherapy resistance mechanisms in HGSC, derived from comprehensive patient-level data and ex vivo experiments. Specifically, I will focus on highlighting computational methods that facilitate high-quality data collection from patient samples, HGSC tumor evolution before and during chemotherapy, as well as translating research findings to benefit patients.
Relevant references for this talk:
Lahtinen A, Lavikka K, Virtanen A, Li Y, Jamalzadeh S, Skorda A, Lauridsen AR, Zhang K, Marchi G, Isoviita VM, Ariotta V, Lehtonen O, Muranen TA, Huhtinen K, Carpén O, Hietanen S, Senkowski W, Kallunki T, Häkkinen A, Hynninen J, Oikkonen J, Hautaniemi S. Evolutionary states and trajectories characterized by distinct pathways stratify patients with ovarian high
grade serous carcinoma. Cancer Cell. 2023 May 11:S1535-6108(23)00143-5. https://doi.org/10.1016/j.ccell.2023.04.017

Zhang K, Erkan EP, Jamalzadeh S, Dai J, Andersson N, Kaipio K, Lamminen T, Mansuri N, Huhtinen K, Carpén O, Hietanen S, Oikkonen J, Hynninen J, Virtanen A, Häkkinen A, Hautaniemi S, Vähärautio A. Longitudinal single-cell RNA-seq analysis reveals stress-promoted chemoresistance in metastatic ovarian cancer. Science Advances. 2022 Feb 25;8(8). https://science.org/doi/10.1126/sciadv.abm1831

Häkkinen A, Zhang K, Alkodsi A, Andersson N, Erkan EP, Dai J, Kaipio K, Lamminen T, Mansuri N, Huhtinen K, Vähärautio A, Carpén O, Hynninen J, Hietanen S, Lehtonen R, Hautaniemi S. PRISM: recovering cell-type-specific expression profiles from
individual composite RNA-seq samples. Bioinformatics. 2021 Sep 29;37(18):2882-2888.


Start time: 13/09/2023 15:00
End time: 15/09/2023 16:00
Duration: 48 hours
Location: remotely
Type: Seminar
Organization: Finnish Cancer Center (FICAN)
Contact person: tuula.kallioinen@hus.fi
Further information: https://www.helsinki.fi/en/researchgroups/systems-biology-of-drug-resistance-in-cancer
Online meeting link: https://teams.microsoft.com/l/meetup-join/19%3ameeting_Yjk1MjhjYWUtNDhkNy00NzBlLTg1OTUtMWIyNmIyNmJlNmVk%40thread.v2/0?context=%7b%22Tid%22%3a%22e307563d-5fcd-4e12-a554-9927f388b1cf%22%2c%22Oid%22%3a%22cd366190-0139-4821-a2d4-dc52228aa886%22%7d
September 14

Dosentin arvon hakijoiden opetusnäytteet

​Dosentin arvoa hakeneet antavat hakemuksen yhteydessä opetusnäytteen. Opetusnäytteet ovat avoimia tilaisuuksia tiedekuntalaisille ja opiskelijoille. Lämpimästi tervetuloa!
Ohjelma:

12:00-12:30 Hammaslääketieteen tohtori Kaija Hiltunen (hammaslääketieteellisen protetiikka ja gerodontologia) aihe: Mitä ikääntyneen suun terveydelle kuuluu; kohderyhmänä: Hammaslääkäri ja lääkäriopiskelijat.

12:30-14:40 Tauko

14:00-14:30 Filosofian tohtori Taru Muranen (bioinformatiikka) aihe: Inference of biological function from transcriptomic analysis; kohderyhmänä: PhD and MSc students.



Start time: 14/09/2023 12:00
End time: 14/09/2023 14:30
Duration: 2 hours 30 minutes
Location: remotely
Type: Docententship lecture
Organization: UH, Faculty of Medicine
Contact person: dosenttiasiat-ltdk@helsinki.fi
Further information:
Online meeting link: https://helsinki.zoom.us/j/62632286911?pwd=MDlIb3ZGYW1nQ3E4VUtjTzV5WHliZz09