KLIINISEN PATOLOGIAN NYKYNÄKYMIÄ: Ari Ristimäki
Kliinisen kemian seminaarit: Hanna Jarva
Wihuri Research Institute Special Seminar by Dr. Paolo Tammaro
Tammaro’s lab’s research interests lie in understanding the molecular mechanisms that regulate
the function of vascular ion channels and in identifying new ion channel
targets and specific compounds with the goal of modulating blood vessel
function for therapeutic benefit. His most recent work focuses on the role of
chloride transport mechanisms in the control of the function of pericytes
(contractile cells that surround capillaries) in regulation of cerebral blood flow after ischemia. The results
suggest that this channel constitutes a key contractile mechanism in cerebral
pericytes, where it may constitute a new drug target for disease of altered
microvascular blood flow such as stroke and vascular dementia.
The Ca2+-gated channel TMEM16A amplifies capillary pericyte contraction and reduces cerebral blood flow after ischemia. Korte N, Ilkan Z, Pearson CL, Pfeiffer T, Singhal P, Rock JR, Sethi H, Gill D, Attwell D, Tammaro P. J Clin Invest. (2022) 132:e154118. doi: 10.1172/JCI154118.
An outer-pore gate modulates the pharmacology of the TMEM16A channel. Dinsdale RL, Pipatpolkai T, Agostinelli E, Russell AJ, Stansfeld PJ, Tammaro P. Proc Natl Acad Sci U S A. (2021) 118(34):e2023572118. doi: 10.1073/pnas.2023572118.
Ion channels as convergence points in the pathology of pulmonary arterial hypertension.
Jouen-Tachoire TRH, Tucker SJ, Tammaro P. Biochem Soc Trans. (2021) 49(4):1855-1865. doi: 10.1042/BST20210538.
Please contact Pipsa Saharinen (email@example.com) for an appointment with the speaker.
iCAN science semiar: Coleman Lindsley
Biostatistics drop-in workshop
The next workshop is on Wednesday 15th February, at 13:00-15:00 in Biomedicum 2B, in the Olohuone on floor 6. Come whenever you can. Note that you may end up waiting a while for your turn, especially early on in the session. We aim to spend no more than 15 minutes with each customer.
· your computer
· your data
· your questions
and we biostatisticians will be on hand to help and guide.
Registration is not required, but you can help us prepare for your questions by filling in this form. The workshops are open to any researcher at the university's Medical Faculty, HUS or FIMM.
The next sessions are planned for 1.3, 15.3, 29.3, 12.4, 26.4, 10.5, and 24.5. For more in-depth questions, please book a one-on-one consultation session using this e-form where we will have time to go into more detail.