February 04

Dissertation: Selina Mäkinen

​Selina Mäkinen, University of Helsinki, Faculty of Medicine, Doctoral Program in Clinical Research
Send in the signals: Studies on the mechanisms of insulin resistance in human skeletal muscle

Opponent: professor Peppi Karppinen,  University of Oulu

Start time: 04/02/2023 13:00
End time: 04/02/2023 15:00
Duration: 2 hours
Location: Naistenklinikka, Seth Wichmann -sali, Haartmaninkatu 2
Type: Dissertation
Organization: UH, Faculty of Medicine
Contact person:
February 06

HiLIFE webinar / Viikki Monday Seminar: Kirill Martemyanov

Terra Incognita of Neuronal GPCR signaling 

Prof. Kirill Martemyanov is the chair of the Department of Neuroscience, Scripps Biomedical Research, University of Florida. The main emphasis of his research is to reveal the fundamental principles that regulate signaling via G protein coupled receptors (GPCRs). GPCRs mediate a vast variety of critical biological processes ranging from proliferation and motility to cellular reception and excitability. GPCR signaling pathways are of particular importance for the nervous system function where they control many fundamental processes including excitability, differentiation, sensory perception and synaptic transmission. Even subtle imbalances in GPCR signaling often lead to the most profound nervous system disorders ranging from blindness and cognitive problems to grave neurological diseases. Scientific publications of Prof. Martemyanov’s research team describe the structure and function of many GPCRs, including the orphan receptors, and previously unknown molecular pathways, activated by them. These discoveries facilitate the understanding of the brain disorders and their possible medication. 

Lab Website 

Twitter: @KLabGPCR 

Welcome to this exciting seminar!  

Svetlana Molchanova 


Selected publications: 

Maza N, Wang D., Kowalski C., Stoveken H.M., Dao M., Sial O.K., Giles A.C., Grill B., Martemyanov K.A. (2022) Ptchd1 is an ancient regulator of opioid tolerance. Nat. Neurosci. 25, 1179-1190; PMID: 35982154 

Patil D.N., Singh S., Laboute T., Strutzenberg T.S., Qiu T., Wu D., Novick S.J., Robinson C.V. Griffin P.R., Hunt J.F., Izard T., Singh A.K., Martemyanov K.A. (2021) Cryo-EM structure of human GPR158 receptor coupled to RGS7-Gβ5 signaling complex. Science, abl4732 

Masuho I., Balaji S., Muntean B.S., Skamangas N.K., Chavali S., Tesmer J.J.G., Babu M.M., Martemyanov K.A. (2020) A global map of G protein signaling regulation by RGS proteins. Cell, 183, 503-521.  

Wang D., Stoveken H.M., Zucca S., Dao M., Orlandi C., Song C., Masuho I., Johnston C., Opperman K.J., Giles A.C., Gill M.S., Lundquist E.A., Grill B., Martemyanov K.A. (2019) Genetic behavioral screen identifies an orphan anti-opioid system. Science, eaau2078.  

Muntean B.S., Zucca S., MacMullen C.M, Dao M.T, Johnston C., Iwamoto H., Blakely R.D., Davis R.L., Martemyanov K.A. (2018) Interrogating spatio-temporal landscape of neuromodulatory GPCR signaling by real-time imaging of cAMP dynamics in intact neurons and circuits. Cell Rep.22, 255-268. 

Wang Y., Fehlhaber K.E., Sarria I., Cao Y., Ingram N.T., Guerrero-Given D., Throesch B., Baldwin K., Kamasawa N., Ohtsuka T., Sampath A.P., Martemyanov K.A. (2017) The auxiliary calcium channel subunit, α2δ4, is required for axonal elaboration, synaptic transmission, and wiring of rod photoreceptors. Neuron 93, 1359-1374. 



University of Helsinki students please note: If you wish to obtain credits (DPBM, ILS)  from this webinar series, please rename yourself in Zoom with first name + last name (do not use nickname/user ID/student number/just first name). 

Start time: 06/02/2023 14:15
End time: 06/02/2023 15:15
Location: Biocenter 2, Lecture Hall 1041, Viikinkaari 5
Type: Webinar
Organization: Helsinki Institute of Life Science HiLIFE
Contact person:
February 09

Wihuri Research Institute Special Seminar by Dr. Taija Mäkinen

The multifaceted role and regulation of the lymphatic vascular system in development and disease

Dr. Taija Mäkinen’s lab’s research interests lie in the understanding of mechanisms that regulate the lymphatic vasculature in development, homeostasis and disease. A major interest of her laboratory is to elucidate how (lymphatic) endothelial cells integrate signals from multiple sources in a complex tissue environment to coordinate vascular morphogenesis and functional specialization. Recently their work has extended to studying how endothelial cells actively modulate their environment through intercellular communication with other cell types, and how regulators of developmental (lymph)angiogenesis impact on genetic human diseases.

Selected publications:


Petkova M, Kraft M, Stritt S, Martinez-Corral I, Ortsäter H, VanlandewijckM, Jakic B, Baselga E, Castillo SD, Graupera M, BetsholtzC, Mäkinen T. Immune-interacting lymphatic endothelial subtype at capillary terminals drives lymphatic malformation. J Exp Med. (2023).


Hernández Vásquez MN, Ulvmar MH, González-Loyola A, Kritikos I, Sun Y, He L, Halin C, Petrova TV, Mäkinen T. Transcription factor FOXP2 is a flow-induced regulator of collecting lymphatic vessels. EMBO J 40(12):e107192. doi: 10.15252/embj.2020107192 (2021).


Martinez-Corral I, Zhang Y, Petkova M, Ortsäter H, Sjöberg S, Diez SC, Brouillard P, Libbrecht L, Graupera M, AlitaloK, Boon L, Vikkula M, Mäkinen T. Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation. Nat Commun 11:2869 doi: 10.1038/s41467-020-16496-y (2020).


Frye M, Stritt S, Ortsäter H, Hernandez-Vasquez M, Kaakinen M, Vicente A, Wiseman J, Eklund L, Martinez-Torrecuadrada JL, Vestweber D, Mäkinen T. EphinB2-EPHB4 signalling provides Rho-mediated homeostatic control of lymphatic endothelial cell junction integrity. eLife 9:e57732 (2020).


Please contact Kari Vaahtomeri ( for an appointment with the speaker.

Start time: 09/02/2023 13:00
End time: 09/02/2023 14:00
Location: Biomedicum1, lecture hall 3, Haartmaninkatu 8, 00290 Helsinki
Type: Seminar
Organization: Wihurin tutkimuslaitos
Contact person:
February 09

4th FICAN seminar: Leena Latonen

Deciphering molecular and tissue mechanisms of prostate cancer
Leena Latonen, Ph.D., FCI K. Albin Johansson Cancer Research Fellow, in Cancer Biology & Vice Director, Institute of Biomedicine

This time the seminar is organized by FICAN East. The seminar will be held online (Microsoft Teams) and is open to everyone interested in cancer research. Join the meeting HERE

Start time: 09/02/2023 15:00
End time: 09/02/2023 16:00
Location: remotely
Type: Webinar
Organization: Finnish Cancer Center (FICAN)
Contact person:
February 14

Dosentin arvon hakijoiden opetusnäytteet

Dosentin arvoa hakeneet antavat hakemuksen yhteydessä opetusnäytteen. Opetusnäytteet ovat avoimia tilaisuuksia tiedekuntalaisille ja opiskelijoille. Lämpimästi tervetuloa!


12:00-12:30 LT Pasi Huttunen (lasten hematologia ja onkologia) aihe: Allogeeniset kantasolusiirrot lapsilla -akuutteja ongelmia vielä viiden vuosikymmenen jälkeenkin?, kohderyhmänä: Lastentauteihin ja lastenhematologiaan erikoistuvat lääkärit.

12:30-12:40 Tauko

12:40-13:10 FT Eevi Kaasinen (bioinformatiikka) aihe: Suurtehosekvensoinnin bioinformatiikka tautimutaatioiden tunnistamisessa, kohderyhmänä: Maisteri- ja jatko-opiskelijat.

13:10-13:20 Tauko

13:20-13:50 FT Riku Katainen (lääketieteellinen genetiikka) aihe: Syövän DNA - haitalliset ja harmittomat muutokset, kohderyhmänä: Maisteri- ja jatko-opiskelijat.

13:50-14:00 Tauko

14:00-14:30 LT Hanna Välimaa (lääketieteellinen mikrobiologia ja immunologia) aihe: Leukaluun osteomyeliitti, kohderyhmänä: Erikoistuvat hammaslääkärit ja lääkärit.

Start time: 14/02/2023 12:00
End time: 14/02/2023 14:30
Duration: 2 hours 30 minutes
Location: remotely
Type: Docententship lecture
Organization: UH, Faculty of Medicine
Contact person: