Events

Dr. Geert Kops is the head of Oncode Institute, an independent research institute dedicated to understanding cancer and translating basic research into clinical practice. His own work focus on chromosome segregation during cell division, specifically molecular mechanisms of chromosome segregation, evolution of the segregation machinery and chromosomal instability diseases. His main research aim is to understand how the cell division process gives rise to two genetically identical daughter cells with a specific focus on the processes that ensure faithful chromosome segregation during mitosis. His past work has significantly contributed to the mechanistic understanding on chromosome segregation errors, which are not only a major cause for birth defects and embryonic lethality in humans but also the most common genetic alterations in human tumors.

Lab web site: www.hubrecht.eu/research-groups/kops-group/

Host: Mikko Frilander 

Please contact mikko.frilander@helsinki.fi if you wish to meet the speaker 

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Recent highlights from Kops lab

Nuclear chromosome locations dictate segregation error frequencies. (2022). Nature. 607:604-609
https://www.nature.com/articles/s41586-022-04938-0

Chromosomal instability by mutations in the novel minor spliceosome component CENATAC. (2021). The EMBO Journal 40:e106536.
https://www.embopress.org/doi/full/10.15252/embj.2020106536

Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids (2019). Nature Genetics 51: 824-834
https://doi.org/10.1038/s41588-019-0399-6

Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis (2018). Nature Cell Biology 20: 800-810. https://www.nature.com/articles/s41556-018-0130-3