Events

November 02

Biostatistics drop-in workshop

Are you a researcher needing support with any statistical aspect of your work? The Biostatistics Consulting Service here at Meilahti Campus holds drop-in workshop sessions every other week to help get you started on your analysis, answer smaller questions etc. We provide service in Finnish, English and Swedish.

 

The next workshop is on Wednesday 2nd November, at 13:00-15:00 in Biomedicum 2, 6th floor Olohuone. Come when you can, stay as long as you need to. Folowing sessions are at the same time on 16th November, 30th Novemeber, and 14th December.

 

Bring: 

  • your computer
  • your data
  • your questions

and we biostatisticians will be on hand to help and guide.

 

Registration is not required, but you can help us prepare for your questions by filling in this form. The workshops are open to any researcher at the university's Medical Faculty, HUS or FIMM. Details will soon be available on our webpage.

 

For more in-depth questions, please book a one-on-one consultation session using this e-form where we will have time to go into more detail.

 

 

From the Biostatistics Team

Hanna, Olavi & Ville


Start time: 02/11/2022 13:00
End time: 02/11/2022 15:00
Duration: 2 hours
Location: Biomedicum 2, 6th floor lounge
Type: Other
Organization: UH, Faculty of Medicine
Contact person: biostat-consult@helsinki.fi
November 03

Metabolomics symposium

We’re pleased to invite you to face-to-face Metabolomics Symposium 2-3
November
. See the full program below and
the 
flyer attached!

 

PLEASE REGISTER HERE: https://elomake.helsinki.fi/lomakkeet/119388/lomake.html

 

Students, come and
earn credits!

 


SCHEDULE

Wednesday 2nd Nov
MEILAHTI Biomedicum, Hall 3, Haartmaninkatu 8

9.15-9.20 Opening words by Prof. Teemu Teeri, PI of
the Metabo-HiLIFE Metabolomics Platform


TOPIC 1 Metabolomics data analysis​
9.20-10.05 Hans Stenlund, Umeå University, SWE:
“Chemometrics in Metabolomics – what, how and why”

coffee
10.30-11.15 Kati Hanhineva, UTU: “Notame-pipeline
in food and nutritional metabolomics data-analysis”

11.15-12.00 Zhixu Ni, TU Dresden, GER: ”LC-MS based
(epi)Lipidomics data analysis and integration workflows”

 

LUNCH (own
expense) 

 

TOPIC 2 MS-based
imaging - DESI & SIMS

13.30-14.15 John Fletcher, University of
Gothenburg, SWE: “Secondary ion mass spectrometry – making the leap from
semiconductors to biology”

14.15-15.00 Ingela Lanekoff, Uppsala University,
SWE: "Quantitative mass spectrometry imaging with nano-DESI"

15.00-15.30 Wei Rao, Waters: "High resolution
mass spectrometry imaging of metabolites with DESI and MALDI"

coffee
MS-based imaging - MALDI
15:45-16.15 Seppo Auriola, UEF: ”MALDI imaging mass
spectrometry in ocular drug research”

16:15-16.45 Andras Kiss, Bruker: "MALDI Mass
Spectrometry Imaging is more than pretty images"


Thursday 3rd Nov VIIKKI Biocenter 2, Hall 2041, Viikinkaari 5

TOPIC 3 LIPIDOMICS
9.15-10.15 Kim Ekroos, Lipidomics Consulting: “Lipidomics
- A Central Field for Advancing Human Health”

coffee

10.45-11.15 Martjin
Molenaar, Utrecht University, NL: "LION/web: a web-suite for
lipidomics data analysis"

11.15-11.45 Satu
Lehti, JYU: “High density cholesterol changes across menopausal change”

11.45-12.15 Cagakan Ozbalci, SCIEX:
"Advancements for metabolomics and lipidomics workflows on ZenoToF
7600"

 

LUNCH (own expense)

 

TOPIC 4
FLUXOMICS AND METABOLIC PROFILING

13.30-14.30 Roland Nilsson, Karolinska
Institutet, SWE: “Towards systematic metabolic flux analysis in human cells and
tissues”

14.30-15.00 Jeffrey Barret,
Nightingale: "Nightingale blood biomarkers and preventative
health"

coffee 

15.30-16.00 Nyasha
Munjoma, Waters: “Lipidomic and DESI imaging study of mouse liver extracts
dosed with tyrosine kinase inhibiting drug”

16.00-16.45 Rahul
Deshpande, Thermo Fisher Scientific: “From data to knowledge:
Intelligence-driven workflow solutions for Metabolomics”

 


Students - ILS-149 course - 1 cr
Obligatory attendance to all 4 seminar
topics during the 2-day symposium (signature required).

Writing of 4 learning diaries, 1
learning diary from each seminar topic (each 1 page long). Send the learning
diaries to 
minna.holopainen@helsinki.fi


Metabolomics Symposium is organized by Viikki
Metabolomics Unit (ViMU), FIMM Metabolomics/​Lipidomics/​Fluxomics Unit (FIMM
Meta) and Helsinki University Lipidomics Unit (HiLIPID).

 

The symposium is
sponsored by Waters.


Start time: 03/11/2022 09:00
End time: 03/11/2022 17:00
Duration: 8 hours
Location: Biocenter 2, Lecture Hall 1041, Viikinkaari 5
Type: Symposium
Organization: UH, Faculty of Medicine
Contact person: Nieminen, Anni I
November 03

FiCAN Seminar: Johanna Ivaska

Cancer cells crossing borders

Johanna Ivaska FCI K. Albin Johansson Research Professor University of Turku Organized by FICAN West

Abstract: Our research focuses on the fundamental role of cell-cell and cell-extracellular matrix crosstalk in maintaining tissue homeostasis. During tumour development, these pathways are altered and trigger the formation of environments that are physically and biochemically more conducive to cancer growth. Recently, we showed that expression of a motor protein MYO10, and MYO10-dependent filopodial extensions, while detrimental in invasive breast cancer and associated with poor patient survival, is protective at the early stage. In pre-invasive ductal carcinoma in situ (DCIS), MYO10 maintains a continuous basement-membrane border around the tumours and prevents dissemination into the surrounding stroma. Therefore, any therapeutic targeting of MYO10 must consider the dual actions of this motor protein and cancer stage. In another work (unpublished), we employed microfluidics to mimic cancer cell interaction with the vasculature (endothelial cell layer) under flow. We found that the method used by cancer cells to cross the endothelial cell barrier differs across cell types but is dependent on cancer-cell–endothelial-cell interaction, often involving the extension of filopodia-like protrusions. We are now employing single-cell mass CyToF and other innovative techniques to understand the molecular details of this interaction and identify a potential therapeutic target.

 

Relevant references for this talk:

E. Peuhu*, G. Jacquemet*, C. Scheele, A. Isomursu, M-C. Laisne, L.M. Koskinen, I. Paatero, K. Thol, M. Georgiadou, C. Guzmán, S. Koskinen, A. Laiho, L.L. Elo, P. Boström,  P. Hartiala, J. van Rheenen, and J. Ivaska*. MYO10-filopodia support basement membranes at pre-invasive tumor boundaries. Developmental Cell (In Press). An earlier version available in the pre-print server bioRxiv. https://doi.org/10.1101/2021.10.22.464987.

Jacquemet G, Paatero I, Carisey AF, Padzik A, Orange JS, Hamidi H, Ivaska J. FiloQuant reveals increased filopodia density during breast cancer progression. J Cell Biol. 2017 Oct 2;216(10):3387-3403. doi: 10.1083/jcb.201704045.

Arjonen A, Kaukonen R, Mattila E, Rouhi P, Högnäs G, Sihto H, Miller BW, Morton JP, Bucher E, Taimen P, Virtakoivu R, Cao Y, Sansom OJ, Joensuu H, Ivaska J. Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis. J Clin Invest. 2014 Mar;124(3):1069-82. doi: 10.1172/JCI67280.

 



Start time: 03/11/2022 15:00
End time: 03/11/2022 16:00
Duration:
Location: remotely
Type: Seminar
Organization: Finnish Cancer Center (FICAN)
Contact person: mertor@utu.fi
November 04

Kliinisen mikrobiologian perjantaisarja

Mykobakteeribiofilmeihin kohdentuvat kokeelliset hoitomuodot
Milka Hammarén, FT, Suomen Akatemian tutkijatohtori
Tampereen yliopisto, EMBL Heidelberg

Start time: 04/11/2022 10:00
End time: 04/11/2022 11:00
Duration: 1 hour
Location:
Type: Seminar
Organization: HUS
Contact person: maarit.ahava@hus.fi
November 04

Dissertation: Markku Vuorinen

​Markku Vuorinen, University of Helsinki, Faculty of Medicine, Doctoral Program in Clinical Research
Risk factors and treatment of hip and knee prosthetic joint infections

Opponent: professor Ville Mattila, University of Tampere


Start time: 04/11/2022 12:00
End time: 04/11/2022 14:00
Duration: 2 hours
Location: Töölön Sairaala, luentosali 1, Topeliuksenkatu 5
Type: Dissertation
Organization: UH, Faculty of Medicine
Contact person: markku.vuorinen@hus.fi