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August 26

Dissertation: Julia Niskanen

​Julia Niskanen, University of Helsinki, Faculty of Medicine, Doctoral Programme in Integrative Life Science
The genetic background of five canine models of rare human disease

Opponent: professor Johanna Schleutker, University of Turku



Start time: 26/08/2022 12:15
End time: 26/08/2022 14:00
Duration: 1 hour 45 minutes
Location: Porthania PII, Yliopistonkatu 3, Helsinki
Type: Dissertation
Organization: UH, Faculty of Medicine
Contact person: julia.niskanen@helsinki.fi
Further information: https://helda.helsinki.fi/handle/10138/346442
Online meeting link:
August 26

Dissertation: Jenni Liikanen

​Jenni Liikanen, University of Helsinki, Faculty of Medicine, Doctoral Program in Clinical Research
PROGNOSTIC FACTORS OF pT1 BREAST CANCER

Opponent: Professor Gábor Cserni, University of Szeged


Start time: 26/08/2022 12:15
End time: 26/08/2022 14:00
Duration: 1 hour 45 minutes
Location: HUS Puistosairaala, Niilo Hallman sali, Stenbäckinkatu 11
Type: Dissertation
Organization: UH, Faculty of Medicine
Contact person: jenni.s.liikanen@gmail.com
Further information: https://helda.helsinki.fi/handle/10138/346620
Online meeting link: https://teams.microsoft.com/l/meetup-join/19%3ameeting_NWE2ZDFkZWItYTEzZS00ZmRjLTk5ZGItYTZmNGQ5ZWNmNDU2%40thread.v2/0?context=%7b%22Tid%22%3a%22e307563d-5fcd-4e12-a554-9927f388b1cf%22%2c%22Oid%22%3a%2282e60a22-c4a0-4cdb-8551-48b0177940d0%22%7d
August 26

Dissertation: Paavo Häppölä

​Paavo Häppölä, University of Helsinki, Faculty of Medicine, Doctoral Program in Population Health
Translating genetic epidemiology to health applications with large-scale biobank data

Opponent: Docent Patrik Magnusson, Karolinska Institutet



Start time: 26/08/2022 13:00
End time: 26/08/2022 15:00
Duration: 2 hours
Location: Biomedicum1, lecture hall 2, Haartmaninkatu 8, 00290 Helsinki
Type: Dissertation
Organization: UH, Faculty of Medicine
Contact person: paavo.happola@helsinki.fi
Further information: https://helda.helsinki.fi/handle/10138/346454
Online meeting link:
August 29

HiLIFE Webinar/ Biomedicum Helsinki seminar: Julia TCW

Cholesterol and matrisome pathways dysregulated in astrocytes and microglia

Dr. Julia TCW is an assistant professor at Boston University (primary appointment at Department of Pharmacology & Experimental therapeutics) and a director of the Laboratory of Human Induced Pluripotent Stem Cell Therapeutics. She received Ph.D. and A.M. in Molecular and Cellular Biology from Harvard University with Biophysics training background and research studies in induced pluripotent stem cell (iPSC) reprogramming in the Department of Stem Cell and Regenerative Biology. She then perused her postdoctoral research in the Department of Neuroscience, Ronald M. Loeb Center for Alzheimer’s Disease, Department of Genetics and Genomic Sciences at Icahn School of Medicine at Mount Sinai, New York, with a research focus of the development of iPSC models and study Alzheimer’s disease (AD) genetics. Currently, the TCW laboratory is aiming at human induced pluripotent stem cell therapeutics for AD and neurodegenerative diseases.  

Welcome to this exciting seminar!  

Liisa Myllykangas 


Selected publications: 

TCW J#, Qian L, Pipalia NH, Chao MJ, Liang SA, Shi Y, Jain B.R., Bertelsen SE, Kapoor M, Marcora E, Sikora E, Andrews EJ, Martini AC, Karch, CM, Head E, Holtzman DM, Zhang B, Wang M, Maxfield FR, Poon WW, Goate AM. Cholesterol and matrisome pathways dysregulated in astrocytes and microglia. Cell, Jun, 2022. https://www.cell.com/cell/pdf/S0092-8674(22)00648-1.pdf 

TCW J*, Preman P*, Snellinx A, Calafate S, Alfonso-Triguero M, Corthout N, Munck S, Rudolf Thal D, Goate AM, De Strooper B, Arranz AM. Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-β plaques. Molecular Neurodegeneration. 2021;16:68. *Co-first authors PMID: 34563212 PMCID: PMC8467145. https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-021-00487-8 

Saroja SR, Gorbachev K, TCW J, Goate AM, Pereira AC. Astrocyte-secreted glypican-4 drives APOE4-dependent tau hyperphosphorylation. PNAS, Jul, 2022. https://www.pnas.org/doi/10.1073/pnas.2108870119 



Start time: 29/08/2022 13:00
End time: 29/08/2022 14:00
Duration: 1 hour
Location: Biomedicum1, lecture hall 3, Haartmaninkatu 8, 00290 Helsinki
Type: Seminar
Organization: Biomedicum Helsinki
Contact person: hilife-seminars@helsinki.fi
Further information: https://www2.helsinki.fi/en/beta/hilife-life-science-seminars/hilife-webinars/hilife-webinars-fall-2020
Online meeting link: https://helsinki.zoom.us/j/67985748419
August 30

Dissertation: Risto Halonen

​Risto Halonen, University of Helsinki, Faculty of Medicine, Doctoral Programme Brain and Mind

Sleep and its oscillatory characteristics in overnight learning - what is the role of plasticity genes BDNF and COMT?
Professor Björn Rasch, University of Fribourg

Start time: 30/08/2022 13:00
End time: 30/08/2022 15:00
Duration: 2 hours
Location: University of Helsinki main building, Fabianinkatu 33, Helsinki
Type: Dissertation
Organization: UH, Faculty of Medicine
Contact person: risto.halonen@helsinki.fi
Further information: https://helda.helsinki.fi/handle/10138/346586
Online meeting link: https://video.helsinki.fi/unitube/live-stream.html?room=l54