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May 25

CancerBio Summer School&Cancer IO Sebinar: Douglas Hanahan

​Hallmarks of Caner - New Dimensions
Douglas Hanahan, born in Seattle, Washington, USA, received a bachelor’s degree in Physics from MIT (1976), and a Ph.D. in Biophysics from Harvard (1983). He worked at Cold Spring Harbor Laboratory in New York (1978-88) initially as a graduate student and then as a group leader. From 1988-2010 he was on the faculty of the Department of Biochemistry & Biophysics at UCSF in San Francisco. Hanahan joined the Lausanne Branch of the Ludwig Institute for Cancer Research as a Distinguished Scholar in January 2020. In addition, Hanahan is currently Professor and Director of the Swiss Institute for Experimental Cancer Research within the School of Life Sciences at EPFL, the Swiss Federal Institute of Technology Lausanne and Co-director of the new multi-institutional Swiss Cancer Center Leman. He has been elected to the American Academy of Arts & Sciences (2007), the US Institute of Medicine (2008), the US National Academy of Science (2009), and EMBO (2010). Hanahan has also received an honorary degree from the University of Dundee in the UK (2011) and the Lifetime Achievement Award from the AACR (2014). 
 
The Hanahan laboratory’s research program is structured around the use of genetically engineered mouse models (GEMMs) of multistep de novo tumorigenesis to investigate the hallmarks of cancer—the many distinct capabilities acquired by tumors and their constituent cells that are essential to the establishment and progression of cancers. The strategic plan is to elucidate the functional and phenotypic manifestations, molecular and cellular mechanisms, and regulation of hallmark capabilities—and to translate that knowledge into clinical applications, diagnostics and therapies. Currently Hanahan group investigates several organ-specific cancers, including ductal and neuroendocrine pancreatic cancers, cervical cancer, melanoma, metastatic breast cancer and glioblastoma. The group also have a robust program exploring the multiple mechanisms of immune evasion employed by tumors and strategies to disable such defenses to boost immunotherapy and broaden its applicability.


Selected publications 

 

D. Hanahan. Hallmarks of Cancer: New Dimensions. Cancer Discovery. 2022-01-01. DOI : 10.1158/2159-8290.CD-21-1059. 

S. Saghafinia; K. Homicsko; A. Di Domenico; S. Wullschleger; A. Perren, et al., D. Hanahan. Cancer Cells Retrace a Stepwise Differentiation Program during Malignant Progression. Cancer Discovery. 2021-10-01. DOI : 10.1158/2159-8290.CD-20-1637. 

Q. Zeng; I. P. Michael; P. Zhang; S. Saghafinia; G. Knott, et al., D. Hanahan. Synaptic proximity enables NMDAR signalling to promote brain metastasis. Nature. 2019-09-26. DOI : 10.1038/s41586-019-1576-6. 

J. Huelsken; D. Hanahan. A Subset of Cancer-Associated Fibroblasts Determines Therapy Resistance. Cell. 2018. DOI : 10.1016/j.cell.2018.01.028. 

S. Saghafinia; M. Mina; N. Riggi; D. Hanahan; G. Ciriello. Pan-Cancer Landscape of Aberrant DNA Methylation across Human Tumors. Cell Reports. 2018-10-23. DOI : 10.1016/j.celrep.2018.09.082. 

K. Shchors; A. Massaras; D. Hanahan. Dual Targeting of the Autophagic Regulatory Circuitry in Gliomas with Repurposed Drugs Elicits Cell-Lethal Autophagy and Therapeutic Benefit. Cancer Cell. 2015. DOI : 10.1016/j.ccell.2015.08.012. 

A. Sadanandam; C. A. Lyssiotis; K. Homicsko; E. A. Collisson; W. J. Gibb, et al., D. Hanahan. A colorectal cancer classification system that associates cellular phenotype and responses to therapy. Nature Medicine. 2013. DOI : 10.1038/nm.3175. 

L. Li; D. Hanahan. Hijacking the Neuronal NMDAR Signaling Circuit to Promote Tumor Growth and Invasion. Cell. 2013. DOI : 10.1016/j.cell.2013.02.051. 

D. Hanahan; R. A. Weinberg. Hallmarks of Cancer: The Next Generation. Cell. 2011. DOI : 10.1016/j.cell.2011.02.013. 

 

 

Find out more information on Professor Hanahan's research and recent publications:

https://www.epfl.ch/labs/hanahan-lab/ 




Start time: 25/05/2022 13:00
End time: 25/05/2022 14:00
Duration: 1 hour
Location: remotely
Type: Seminar
Organization: CancerBio Summer School
Contact person: mariel.savelius@helsinki.fi
Further information:
Online meeting link: https://helsinki.zoom.us/j/64902684556?pwd=bW1JTG4rdXFuRjlsbDJIc2pDb3YrZz09
May 25

Docentship lecture: Takashi Namba

"Adult neurogenesis in the human hippocampus: Death of a dogma or not?”

 

Length is 30min, after which there is discussion, and then the audience will evaluate the lecture. 


Start time: 25/05/2022 14:00
End time: 25/05/2022 15:00
Duration:
Location: Biomeiducm 1, meeting room 3
Type: Docententship lecture
Organization: UH, Faculty of Medicine
Contact person: anu.wartiovaara@helsinki.fi
Further information:
Online meeting link:
May 27

Dissertation: Pauliina Reijonen

​Pauliina Reijonen, University of Helsinki, Faculty of Medicine, Doctoral Program in Clinical Research
Risk factors of successful liver metastasectomy in colorectal cancer

Opponent: doent Marja Hyöty, University of Tampere



Start time: 27/05/2022 12:00
End time: 27/05/2022 14:00
Duration: 1 hour
Location: Haartman Institute, lecture hall 2, Haartmaninkatu 3, 00290 Helsinki
Type: Dissertation
Organization: UH, Faculty of Medicine
Contact person: pauliina.reijonen@hus.fi
Further information: https://helda.helsinki.fi/handle/10138/342706
Online meeting link:
May 27

Dissertation: Liisa Harjama

​Liisa Harjama, University of Helsinki, Faculty of Medicine, Doctoral Program in Clinical Research
Hereditary palmoplantar keratoderma in Finland

Opponent: professor Edel O'Toole, Queen Mary University of London



Start time: 27/05/2022 12:00
End time: 27/05/2022 14:00
Duration: 2 hours
Location: HUS Skin- and allergyhospital, lecture hall 1, Meilahdentie 2
Type: Dissertation
Organization: UH, Faculty of Medicine
Contact person: liisaharjama@gmail.com
Further information: https://helda.helsinki.fi/handle/10138/342842
Online meeting link:
May 27

Dissertation: Elisa Hackenberg

​Elisa Hackenberg, University of Helsinki, Faculty of Medicine, Doctoral Program in Clinical Research
Trauma-informed care for injuries after intimate partner violence
Opponent: associate professor Joonas Sirola, University of Kuopio


Start time: 27/05/2022 12:00
End time: 27/05/2022 14:00
Duration: 2 hours
Location: Töölön Sairaala, luentosali 1, Topeliuksenkatu 5
Type: Dissertation
Organization: UH, Faculty of Medicine
Contact person: elisa.hackenberg@hus.fi
Further information: https://helda.helsinki.fi/handle/10138/343391
Online meeting link: