Events

Christos Pliotas obtained a BSc in Physics at the University of Athens and an MSc and PhD at the University of Aberdeen in Scotland. He did his postdoc at the University of St Andrews with James H. Naismith FRS and was then awarded a Royal Society of Edinburgh Fellowship to start his own lab at the Biomedical Sciences Research Complex, University of St Andrews in 2016. Christos moved to the Astbury Centre for Structural Molecular Biology, University of Leeds in October 2018, as an Assistant Professor in Integrative Membrane Biology. During his time there, he received a BBSRC New Investigator Award (2019) and the Sir Robin MacLellan Award Tenovus (2022). As of June 2023, he has moved to the School of Biological Sciences, at The University of Manchester, as a Reader in Structural Biological EPR Spectroscopy. Christos has been recently elected as a Fellow of the Royal Society of Biology (FRSB) and is also affiliated with the Manchester Institute of Biotechnology. In Manchester, he will launch the new BioEmPiRe Centre for Structural Biological EPR Spectroscopy in 2025.

Pliotas Group   @pliotasgroup.bsky.social

Welcome to this exciting seminar!

Adrian Goldman

Selected publications:

Liu^, J., Shah^, A., Liu, X., Wort, J.L., Wort Ma, Y., Hardman, K., Johansson, N.J., Ribeiro, O., Brookfield, A., Bowen, A., Yli-Kauhaluoma, Y., Xhaard, H., Jeuken, L.J.C., Goldman*, A., Pliotas*, C., Vidilaseris*, K. (2025) Conformational dynamics and asymmetry in multimodal inhibition of membrane-bound pyrophosphatases. eLife (doi: 10.7554/eLife.102288.1)

Lane, B.J., Dionysopoulou, M., Yan, N., Lippiat, J.D., Muench, S.P., Pliotas*, C. (2025) The mechanosensitive channel YbiO has a conductance equivalent to the largest gated-pore. Structure 33: 1-11 (doi: 10.1016/j.str.2025.01.014))

Lane^, B.J., Ma^, Y., Yan^, N., Wang, B., Ackermann, K., Karamanos, T.K., Bode, B.E., and Pliotas*, C. (2024) Monitoring the Conformational Ensemble and Lipid Environment of a Mechanosensitive Channel Under Cyclodextrin-Induced Membrane Tension. Structure 32: 1-12 (doi:10.1016/j.str.2024.02.020)

Haysom, S.F., Machin, J., Whitehouse, J.M., Horne, J.E., Fenn, K., Ma, Y., Hassane El Mkami, Nils Böhringer, Schäberle, T.F., Ranson, N.A., Radford*, S.E., and Pliotas*, C. (2023) Darobactin B Stabilises a Lateral-Closed Conformation of the BAM Complex in E. coli Cells. Angew Chem Int Ed, p.e202218783 (doi: 10.1002/ange.202218783)

Kapsalis, C., Wang, B., El Mkami, H., Pitt, S. J., Schnell, J. R., Smith, T.K., Lippiat, J.D., Bode, B.E., Pliotas*, C. (2019) Allosteric activation of an ion channel triggered by modification of mechanosensitive nanopockets. Nat Commun 10:4619. (doi: 10.1038_s41467-019-12591-x)