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April 05

Dissertation: Mirjami Laivuori

Mirjami Laivuori, University of Helsinki, Faculty of Medicine, Doctoral Program in Clinical Research, epartment of Vascular Surgery, Helsinki University Hospital
Prognosis of patients with lower extremity arterial disease - from noninvasive diagnostic evaluation to histologic plaque characteristics

Opponent: professor Philippe Kolh, University of Liège


Start time: 05/04/2024 12:00
End time: 05/04/2024 14:00
Duration: 2 hours
Location: HUS Siltasairaala, Kruunuhakasali, Haartmaninkatu 4
Type: Dissertation
Organization: UH, Faculty of Medicine
Contact person: mirjami.laivuori@hus.fi
Further information: https://helda.helsinki.fi/items/5396dfb5-a9d0-4db7-85c4-6cdd146c7235
Online meeting link:
April 05

Dissertation: John Söderholm

John Söderholm, University of Helsinki, Faculty of Medicine, Doctoral Program in Clinical Research
Suicidality, depression severity, and borderline features in unipolar and bipolar depression

Opponent: Professor Emeritus Jyrki Korkeila, University of Turku



Start time: 05/04/2024 12:00
End time: 05/04/2024 14:00
Duration: 2 hours
Location: HUS Psykiatriakeskus, Christian Sibelius -sali, Välskärinkatu 12
Type: Dissertation
Organization: UH, Faculty of Medicine
Contact person: john.soderholm@helsinki.fi
Further information: https://helda.helsinki.fi/items/84be71c8-ba1f-405c-91fa-fe85760944b0
Online meeting link:
April 08

HiLIFE webinar / Biomedicum Helsinki seminar: Franziska Richter Assencio

Treatment of co-proteinopathies: should we target tau in Parkinson’s disease?

Dr. Franziska Richter Assencio got her PhD from Free University of Berlin at 2007, and thereafter she did a 5-year post doctoral training in Marie-Françoise Chesselet’s laboratory at University of California Los Angeles (UCLA, USA). Dr. Richter Assencio worked in Leipzig University in 2012-2019 as assistant/associate professor in pharmacology and toxicology, before receiving full professorship in University of Veterinary Medicine Hannover, Foundation (TiHo). Her research has focused on translational preclinical drug development, particularly in neurological disorders and novel drug delivery systems.

 

Welcome to this exciting seminar! 

Timo Myöhänen

 

Selected publications: 

Schidlitzki A, Stanojlovic M, Fournier C, Käufer C, Feja M, Gericke B, Garzotti M, Welford RWD, Steiner M, Angot E, Richter F (2023) Double-edged effects of venglustat on behavior and pathology in mice overexpressing alpha-synuclein. Mov Disord 2023 Jun;38(6):1044-1055.

Richter F, Stanojlovic M., Käufer C, Gericke B, Malte F (2023) A mouse model to test novel therapeutics for Parkinson’s disease: an update on the Thy1-aSyn (“line 61”) mice. Neurotherapeutics DOI: 10.1007/s13311-022-01338-0 PMID: 36715870

Käufer C, Schreiber CS, Hartke AS, Denden I, Stanelle-Bertram S, Beck S, Kouassi NM, Beythien G, Becker K, Schreiner T, Schaumburg B, Beineke A, Baumgärtner W, Gabriel G, Richter F (2022) Microgliosis and neuronal proteinopathy in brain persist beyond viral clearance in SARS-CoV-2 hamster model. EBioMedicine 79, 103999. PMID: 35439679

Torres ERS, Stanojlovic M, Zelikowsky M, Bonsberger J, Hean S, Mulligan C, Baldauf L, Fleming S, Masliah E, Chesselet MF, Fanselow MS, Richter F (2021) Alpha-synuclein pathology, microgliosis, and parvalbumin neuron loss in the amygdala associated with enhanced fear in the Thy1-aSyn model of Parkinson's disease. Neurobiol Dis. 158, 105478. PMID: 34390837

Helmschrodt C, Höbel S, Schöniger S, Bauer A, Bonicelli J, Gringmuth M, Fietz SA, Aigner A, Richter A, Richter F (2017) Polyethylenimine nanoparticle-mediated siRNA delivery to reduce alpha-synuclein expression in a model of Parkinson’s disease. Molecular Therapy Nucleic Acids 9, 57-68.



Start time: 08/04/2024 13:00
End time: 08/04/2024 14:00
Duration: 1 hour
Location: Biomedicum1, lecture hall 1, Haartmaninkatu 8, 00290 Helsinki
Type: Seminar
Organization: Helsinki Institute of Life Science HiLIFE
Contact person: hilife-seminars@helsinki.fi
Further information: https://www.helsinki.fi/en/hilife-helsinki-institute-life-science/research/hilife-life-science-seminars/hilife-webinars
Online meeting link: https://helsinki.zoom.us/j/65074851967
April 10

Pharmacology Department Seminars

Juho Väänänen. PhD. University of Helsinki, Functional Genomics Unit (FuGU).

Bioinformatics in RNA analysis
Start time: 10/04/2024 14:15
End time: 10/04/2024 15:15
Duration:
Location: Biomedicum 1, seminar room B201a
Type: Seminar
Organization: UH, Faculty of Medicine
Contact person: Piet.Finckenberg@Helsinki.Fi
Further information:
Online meeting link:
April 10

FICAN science webinar

Topic: Unveiling the immune landscape of colorectal cancer through quantitative, spatially resolved techniques
Speaker: Juha Väyrynen, MD, PhD, Adjunct professor in Cancer Biology, University of Oulu and Oulu University Hospital

This time the seminar is organized by FICAN North. The seminar will be held online (Microsoft Teams) at 15:00-16:00 and is open to everyone interested in cancer research:

Abstract:
Recent advances in cancer immunology have led to new cancer therapies activating anti-tumor immune responses. Studies have revealed that high lymphocyte densities are associated with favorable outcome in colorectal cancer, and the Immunoscore (IS), which measures CD3+ and
CD8+ T-cell densities, is an independent prognostic factor in colon cancer, surpassing the traditional TNM (tumor-node-metastasis) classification. However, the IS only considers cell densities and overlooks the spatial localization of immune and tumor cells.
 
The immune system can also aid tumor growth by supporting cell proliferation and angiogenesis and dampening anti-tumor immunity. Immature myeloid immune cells can be abnormally produced in cancer, leading to myeloid-derived suppressor cell (MDSC) accumulation.
Besides MDSCs, mature myeloid cells like macrophages are prevalent in the tumor microenvironment and affect tumor progression. Their role is complex, with a range of pro- and anti-inflammatory states, needing multi-marker approaches for accurate assessment.
 
We have utilized supervised machine learning based image analysis combined with hematoxylin-eosin staining or multiplex immunohistochemistry to recognize various immune cell populations in the colorectal cancer microenvironment. We have utilized spatial analysis methods to characterize the spatial patterns of immune cell infiltrates. Our results have identified several prognostically favorable (such as T cells, M1-like macrophages, mature monocytic cells, eosinophils) and unfavorable (such as M2-like macrophages and immature monocytic cells) cell types and shown that spatial immune features also harbor prognostic relevance. Our findings pave the way for developing advanced tumor-immune biomarkers for precision medicine.

Start time: 10/04/2024 15:00
End time: 10/04/2024 16:00
Duration:
Location: remotely
Type: Webinar
Organization: Finnish Cancer Center (FICAN)
Contact person: tuula.kallioinen@hus.fi
Further information:
Online meeting link: https://teams.microsoft.com/l/meetup-join/19%3ameeting_ODFiYTM4NDEtMjMwNS00MDk2LTkzZWMtOTdjNTgxMWY1OTlm%40thread.v2/0?context=%7b%22Tid%22%3a%229837ed87-b378-4f49-a0d1-fb48e67da013%22%2c%22Oid%22%3a%222fd1052d-f35f-426f-8b0c-30f81802e559%22%7d