Events
Single cell RNAseq workshop
Time: Mon-Tue 23.-24.10.2023 at 9:00-11:00
Single cell RNAseq workshop 2023 wet-lab
Time: Mon-Tue 23.-24.10.2023 at 12:00-16:00
More information and links to registration:
HiLIFE webinar / Biomedicum Helsinki seminar: Sophie Janssens
Cholesterol metabolism at the decision point between homeostatic and immunogenic dendritic cell maturation
Sophie Janssens received her Master in Biology at the University of Antwerp and her PhD in Sciences at the University of Ghent (2003), where she studied the role of MyD88 in innate immune signalling. She went for her postdoc to the lab of Prof. J. Tschopp at the University of Lausanne (2005) to work on the PIDDosome, a complex involved in cell fate decisions upon DNA damage. After a second postdoc in a Peripheral Neuropathy Group at the University of Antwerp to study the role of disease causing mutations in Charcot Marie Tooth, she became Full Professor at the University of Ghent to coordinate a novel research line on ER stress and inflammation (2011).
Her Lab studies the role of the unfolded protein response in dendritic cells in vivo, both in steady state as during viral infections. This led them to uncover a novel role of IRE1 in controlling lipid metabolic pathways in DCs that play a crucial role in homeostatic dendritic cell maturation.
Welcome to this exciting seminar!
Related publications:
- Bosteels, V. et al. LXR signaling controls homeostatic dendritic cell maturation. Science Immunol 8(83):eadd3955, 2023. https://www.science.org/stoken/author-tokens/ST-1201/full
- Vetters, J. et al. The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF. J Exp Med 216, 2010-2023, 2019.
- Tavernier, S.J., et al. Regulated IRE1-dependent mRNA decay sets the threshold for dendritic cell survival. Nature Cell Biology, 19, 698-710, 2017.
- Osorio, F., et al. The unfolded-protein-response sensor IRE-1alpha regulates the function of CD8alpha+ dendritic cells. Nature Immunology, 15, 248-257, 2014.
- Janssens, S., et al. Emerging functions of the unfolded protein response in immunity. Nature Immunology, 15, 910-919, 2014.
iCAN seminar: Cancer cells crossing borders, prof. Johanna Ivaska
Johanna Ivaska is a K Albin Johansson Professor at the University of Turku. She started her own group at the VTT Technical Research Centre of Finland in 2003. In 2013, she joined the University of Turku Bioscience Centre where she currently leads the “Cell Adhesion and Cancer” group.