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January 09

Science talks and Teaching demonstrations of HiLIFE Assistant/Associate professor candidates

​The science talks take place before noon. During the 20-minute short talk followed by 5-minute discussion the candidates present their past achievements and future research directions. During the afternoon Teaching demonstrations, the candidates have an opportunity to demonstrate their teaching skills by giving a 20-minute pretend teaching event intended for Master's level students - except that the whole audience present in the demonstration (students, faculty members and the Teaching Skills Evaluation Committee) is regarded as students with whom they interact.

Science talks 9:30-11 AM

Katri Korpela, University of Helsinki, Faculty of Medicine
“Infant gut microbiota development"

Tommi Vatanen, University of Helsinki, Faculty of Medicine
“Known unknowns of human gut microbiomes”

Alexander Mühleip, University of Glasgow, School of Infection and Immunity, Wellcome Centre
for Integrative Parasitology
“Uncovering the molecular basis of cristae formation”
Teaching demonstrations
12.30 – 13.00 Tommi Vatanen, University of Helsinki, Faculty of Medicine
14.00 – 14.30 Katri Korpela, University of Helsinki, Faculty of Medicine
14.45 – 15.15 Alexander Mühleip, University of Glasgow, School of Infection and Immunity,
Wellcome Centre for Integrative Parasitology

Start time: 09/01/2023 09:30
End time: 09/01/2023 15:30
Duration: 6 hours
Location: Biocenter 2, Lecture Hall 1041, Viikinkaari 5
Type: Lecture
Organization: Helsinki Institute of Life Science HiLIFE
Contact person: salla.leppanen@helsinki.fi
Further information: https://flamma.helsinki.fi/en/group/ajankohtaista/news/-/uutinen/welcome-to-listen-science-talks-and-teaching-demonstrations-of-hilife-assistantassociate-professor-candidates/30571844
Online meeting link:
January 09

Special Seminars by Drs. Tuomas Tammela and Pekka Katajisto

​Differentiation mimicry as a novel mechanism of resistance to KRAS-targeted therapy in lung cancer
​Dr. Tuomas Tammela Memorial Sloan Kettering Cancer Center, New York, NY

Dr. Tuomas Tammela’s lab is interested in understanding the remarkable phenotypic heterogeneity of cancer cells within tumors. They approach this question using a combination of sophisticated genetically engineered mouse models, single-cell approaches, tracing and ablation of distinct tumor cell lineages, CRISPR-mediated gene regulation, and advanced imaging techniques. Tammela’s goal is to discover pathways that drive distinct cellular phenotypes and to develop new therapeutic concepts aimed at reducing cellular heterogeneity in tumors.

 

https://www.mskcc.org/research/ski/labs/tuomas-tammela

 

Recent publications:

 

Pitter KL, Grbovic-Huezo O, Joost S, Singhal A, Blum M, Wu K, Holm M, Ferrena A, Bhutkar A, Hudson A, Lecomte N, de Stanchina E, Chaligne R, Iacobuzio-Donahue CA, Pe'er D, Tammela T. Systematic Comparison of Pancreatic Ductal Adenocarcinoma Models Identifies a Conserved Highly Plastic Basal Cell State. Cancer Res. 2022 Oct 4;82(19):3549-3560.

 

Torborg SR, Li Z, Chan JE, Tammela T. Cellular and molecular mechanisms of plasticity in cancer. Trends Cancer. 2022 Sep;8(9):735-746.

 

Marjanovic ND, Hofree M, Chan JE, …, Tammela T. Emergence of a High- Plasticity Cell State during Lung Cancer Evolution. Cancer Cell. 2020 Aug 10;38(2):229-246.e13.



Metabolic cell fate regulation through selective segregation of organelles
Dr. Pekka Katajisto, University of Helsinki

Dr. Pekka Katajisto’s laboratory studies both stem cell intrinsic, and extrinsic mechanisms altering tissue renewal capacity, and how such mechanisms ultimately result in the functional decline we recognize as aging. Tissue resident stem cells (aka. adult stem cells) renew and repair our tissues. However, in order to secure tissue homeostasis, generation of new stem cells via self-renewal and their differentiation into functional cells must be carefully balanced. During aging, multiple types of alterations directly in stem cells, or in their tissue neighbourhood can disturb this balance.

 

https://www.katajisto-lab.com/

 

Recent publications:

Englund JI, Bui H, Dinç DD, Paavolainen O, McKenna T, Laitinen S, Munne P, Klefström J, Peuhu E, Katajisto P. Laminin matrix adhesion regulates basal mammary epithelial cell identity. J Cell Sci. 2022 Dec 1;135(23):jcs260232.

 

Pentinmikko N, Lozano R, Scharaw S, Andersson S, Englund JI, Castillo- Azofeifa D, Gallagher A, Broberg M, Song KY, Sola Carvajal A, Speidel AT, Sundstrom M, Allbritton N, Stevens MM, Klein OD, Teixeira A, Katajisto P. Cellular shape reinforces niche to stem cell signaling in the small intestine. Sci Adv. 2022 Oct 14;8(41):eabm1847.

 

Azkanaz M, Corominas-Murtra B, Ellenbroek SIJ, Bruens L, Webb AT, Laskaris D, Oost KC, Lafirenze SJA, Annusver K, Messal HA, Iqbal S, Flanagan DJ, Huels DJ, Rojas-Rodríguez F, Vizoso M, Kasper M, Sansom OJ, Snippert HJ, Liberali P, Simons BD, Katajisto P, Hannezo E, van Rheenen J. Retrograde movements determine effective stem cell numbers in the intestine. Nature. 2022 Jul;607(7919):548-554.







Start time: 09/01/2023 12:00
End time: 09/01/2023 13:00
Duration:
Location: Biomedicum1, lecture hall 3, Haartmaninkatu 8, 00290 Helsinki
Type: Seminar
Organization: UH, Faculty of Medicine
Contact person: saija.piiroinen@helsinki.fi
Further information:
Online meeting link: https://helsinki.zoom.us/j/66193737299?pwd=Nzlyek1GakU1Q1dZNHE2TUREYmtndz09
January 10

Science talks and Teaching demonstrations of HiLIFE Assistant/Associate professor candidates

​The science talks take place before noon. During the 20-minute short talk followed by 5-minute discussion the candidates present their past achievements and future research directions. During the afternoon Teaching demonstrations, the candidates have an opportunity to demonstrate their teaching skills by giving a 20-minute pretend teaching event intended for Master's level students - except that the whole audience present in the demonstration (students, faculty members and the Teaching Skills Evaluation Committee) is regarded as students with whom they interact.

Science talks 9-11:00
Claudius Kratochwil, University of Helsinki, Institute of Biotechnology, HiLIFE
“Genomic and developmental drivers of color pattern evolution”

Laura Antão, University of Helsinki, Faculty of Biological and Environmental Sciences
“Elucidating biodiversity change in the Anthropocene”

Kaisa Kajala, Utrecht University
“Evolution of dynamic plant root barriers"

Ilkka Kronholm, University of Jyväskylä
“How do properties of epigenetic changes and genetic mutations influence adaptation”
Teaching demonstrations
12.30 – 13.00 Laura Antão, University of Helsinki, Faculty of Biological and Environmental
Sciences
13.15 – 13.45 Ilkka Kronholm, University of Jyväskylä
14.00 – 14.30 Claudius Kratochwil, University of Helsinki, Institute of Biotechnology, HiLIFE
14.45 – 15.15 Kaisa Kajala, Utrecht University

Start time: 10/01/2023 09:00
End time: 10/01/2023 15:30
Duration: 6 hours 30 minutes
Location: Biocenter 2, Lecture Hall 1041, Viikinkaari 5
Type: Lecture
Organization: Helsinki Institute of Life Science HiLIFE
Contact person: salla.leppanen@helsinki,fi
Further information: https://flamma.helsinki.fi/en/group/ajankohtaista/news/-/uutinen/welcome-to-listen-science-talks-and-teaching-demonstrations-of-hilife-assistantassociate-professor-candidates/30571844
Online meeting link:
January 11

Science talks and Teaching demonstrations of HiLIFE Assistant/Associate professor candidates

​​The science talks take place before noon. During the 20-minute short talk followed by 5-minute discussion the candidates present their past achievements and future research directions. During the afternoon Teaching demonstrations, the candidates have an opportunity to demonstrate their teaching skills by giving a 20-minute pretend teaching event intended for Master's level students - except that the whole audience present in the demonstration (students, faculty members and the Teaching Skills Evaluation Committee) is regarded as students with whom they interact.

Science talks 9:30-11:30

Jette Lengefeld, University of Helsinki, Institute of Biotechnology, HiLIFE

“How size affects stem cell function”

Anniina Färkkilä, University of Helsinki, Faculty of Medicine
“Immunogenomic profiling for precision oncology ovarian cancer”

Simon Pfisterer, University of Helsinki, Faculty of Medicine
"Functional Profiling of Genetic Variants and Human Patient Samples Using Automated
Systems”

Andrea Ganna, University of Helsinki, FIMM, HiLIFE
"A world-leading program in health data science"

Teaching demonstration

12.30 – 13.00 Jette Lengefeld, University of Helsinki, Institute of Biotechnology, HiLIFE
13.15 – 13.45 Andrea Ganna, University of Helsinki, FIMM, HiLIFE
14.00 – 14.30 Anniina Färkkilä, University of Helsinki, Faculty of Medicine
14.45 – 15.15 Simon Pfisterer, University of Helsinki, Faculty of Medicine
Start time: 11/01/2023 09:30
End time: 11/01/2023 15:30
Duration: 6 hours
Location: Biomedicum1, lecture hall 1, Haartmaninkatu 8, 00290 Helsinki
Type: Lecture
Organization: Helsinki Institute of Life Science HiLIFE
Contact person: salla.leppanen@helsinki.fi
Further information: https://flamma.helsinki.fi/en/group/ajankohtaista/news/-/uutinen/welcome-to-listen-science-talks-and-teaching-demonstrations-of-hilife-assistantassociate-professor-candidates/30571844
Online meeting link:
January 13

Dissertation: Claudia Taipale

​​Claudia Taipale, University of Helsinki, Faculty of Medicine, Doctoral Program in Clinical Research
Age-related macular degeneration - Optimizing anti-VEGF treatment and quality of life after cataract surgery

Opponent: professor Morten Moe, University of Oslo

Start time: 13/01/2023 12:00
End time: 13/01/2023 14:00
Duration: 1 hour
Location: Biomedicum1, lecture hall 3, Haartmaninkatu 8, 00290 Helsinki
Type: Dissertation
Organization: UH, Faculty of Medicine
Contact person: claudia.taipale@gmail.com
Further information: https://helda.helsinki.fi/handle/10138/352093
Online meeting link: