Events

Show current events
May 06

HiLIFE webinar / Viikki Monday Seminar: Tamra Mendelson

Beauty and speciation in North American freshwater fishes

Mendelson earned her PhD at Duke University studying speciation in darters, a group of colorful North American fishes. Currently a Professor at the University of Maryland, Baltimore County, USA, Mendelson collaborates internationally to study the evolution of elaborate visual ornamentation and sex roles in speciation.

Mendelson lab   @tamram

 

Prof Mendelson will be in Helsinki on Monday and Tuesday 6-7 May. If you would like to schedule a meeting with her, please contact Sandra Winters (sandra.winters@helsinki.fi).

Welcome to this exciting seminar! 

Sandra Winters

 

Selected publications:

Mendelson, T.C. and Ryan, M.J. 2022. Beauty in nature: sex and design in our evolutionary cousins. Mètode Science Studies Journal 13:145-151.

Mendelson, T.C.* and Safran, R.J.* 2021. Speciation by sexual selection: 20 years of progress. Trends in Ecology & Evolution 36:1153-1163. *Authors contributed equally.

Hulse, S.V.G, Renoult, J.P.*, Mendelson, T.C.* 2020. Sexual signaling pattern correlates with habitat pattern in visually ornamented fishes. Nature Communications 11:1-8. *Authors contributed equally.

Renoult, J.P. and Mendelson, T.C. 2019. Processing bias: extending sensory drive to include efficacy and efficiency in information processing. Proceedings of the Royal Society, Series B 286:20190165.

Mendelson, T.C., Fitzpatrick, C.L., Hauber, M.E., Pence, C.H., Rodríguez, R.L., Safran, R.J., Stern, C.A., and Stevens, J.R.  2016. Cognitive phenotypes and the evolution of animal decisions. Trends in Ecology & Evolution 31: 850-859.

Martin, M.D. G and Mendelson, T.C. 2016. Male behavior predicts trait divergence and the evolution of reproductive isolation in darters (Percidae: Etheostoma). Animal Behaviour 112: 179-186.

************************************

University of Helsinki students please note: If you wish to obtain credits (DPBM, ILS) from this webinar series, please rename yourself in Zoom with first name + last name (do not use nickname/user ID/student number/just first name).


Start time: 06/05/2024 13:00
End time: 06/05/2024 14:00
Duration: 1 hour
Location: Biocenter 2, Lecture Hall 1041, Viikinkaari 5
Type: Seminar
Organization: Helsinki Institute of Life Science HiLIFE
Contact person: hilife-seminars@helsinki.fi
Further information: https://www.helsinki.fi/en/hilife-helsinki-institute-life-science/research/hilife-life-science-seminars/hilife-webinars
Online meeting link: https://helsinki.zoom.us/j/65074851967
May 08

Dissertation: Pinja Elomaa

Pinja Elomaa, University of Helsinki, Faculty of Medicine, Doctoral Program in Clinical Research
Simple devices for single-cell trapping and droplet digital PCR

Opponent: professor Marja Tiirola, University of Jyväskylä


Start time: 08/05/2024 12:00
End time: 08/05/2024 14:00
Duration: 2 hours
Location: Biomedicum1, lecture hall 2, Haartmaninkatu 8, 00290 Helsinki
Type: Dissertation
Organization: UH, Faculty of Medicine
Contact person: pinja.elomaa@helsinki.fi
Further information: https://helda.helsinki.fi/items/b594fde0-5582-4294-89f9-f88ba5ea9fd5
Online meeting link:
May 08

Biostatistics drop-in workshop

Are you a researcher needing support with any statistical aspect of your work? The Biostatistics Consulting Service here at Meilahti Campus holds drop-in workshop sessions every other week to answer smaller questions about your analysis - solving a particular problem, how to get started, etc. We provide service in Finnish, English and Swedish.

 

The next workshop is on Wednesday 8th May, at 13:00-15:00 in Biomedicum 2B, in the Olohuone on floor 6. Come whenever you can. Note that you may end up waiting a while for your turn, especially early on in the session. We aim to spend no more than 15 minutes with each customer.

 

Bring: 

·       your computer

·       your data

·       your questions

and we biostatisticians will be on hand to help and guide. 

 

Registration is not required, but you can help us prepare for your questions by filling in this form. The workshops are open to any researcher at the university's Medical Faculty, HUS or FIMM.

The next session is the last one for this academic year: 22.5.

We plan to continue again in August.

 

For more in-depth questions, please book a one-on-one consultation session using this e-form where we will have time to go into more detail. 

 

From the Biostatistics Team


Start time: 08/05/2024 13:00
End time: 08/05/2024 15:00
Duration: 2 hours
Location: Biomedicum 2, 6th floor lounge
Type: Other
Organization: Biostatistics Consulting Service
Contact person: biostat-consult@helsinki.fi
Further information: https://www.helsinki.fi/en/infrastructures/biostatistics-unit/consulting
Online meeting link:
May 08

Pharmacology Department Seminars

Rekonstruktiivinen kirurgia 1800-luvun Helsingissä
Maija Kolehmainen, LL. HUS


Start time: 08/05/2024 14:15
End time: 08/05/2024 15:00
Duration: 45 minutes
Location: Biomedicum 1, seminar room B201a
Type: Seminar
Organization: UH, Faculty of Medicine
Contact person: Piet.Finckenberg@Helsinki.Fi
Further information:
Online meeting link:
May 08

FICAN webinar: prof Olli Lohi

Precision Therapy for Childhood Leukemia: Improving Outcomes and Reducing Toxicities
Speaker: prof. Olli Lohi, Faculty of Medicine and Health Technology, Tampere University and Tampere University Hospital
FICAN webinars are jointly organized by regional cancer centers. This webinar is organized by FICAN Mid- Sisä-Suomen syöpäkeskus.
The seminar will be held online (Microsoft Teams) and is open to everyone interested in cancer research. Teams link can be found below.

Abstract: Childhood acute lymphoblastic leukemia (ALL), the most common cancer among children, has traditionally been managed with chemotherapy regimens. While these treatments are effective, they often lead to significant toxicities and long-term side effects for survivors. The implementation of response-based risk grouping has been crucial in customizing therapies, thereby significantly enhancing outcomes and reducing treatment-related toxicities. The introduction of modern sequencing technologies has unveiled the complexity of the disease by identifying numerous genetically distinct subtypes, each with unique behaviors and responses to treatment. This shift towards personalized medicine is underscored by the exploration of immunotherapies and novel targeted agents for cases that relapse or show poor response, representing a considerable departure from conventional chemotherapy methods.

Our recent discovery involves the application of the general tyrosine kinase inhibitor dasatinib as a targeted treatment for both T-cell and B-cell ALL. In particular, the effectiveness of a combination therapy that included dasatinib and temsirolimus for T-ALL was shown in patient samples and preclinical animal models. Additionally, the sequential treatment of B-ALL with an inhibitor of Wee1, a cell cycle regulator, and dasatinib was effective in eliminating an escape pathway for residual leukemic cells. Furthermore, in collaboration with European partners, we have begun to delineate the genetic landscape of slow responding leukemias within the second common subtype of ALL, expected to have a favorable outcome.

The importance of international collaboration is critical in hastening the development of novel treatments for childhood leukemias. The advent of immunotherapies as a frontline therapy modality represents the next frontier, with high hopes for achieving greater efficacy and reduced harm simultaneously.

Selected publications:

Zapilko V, Moisio S, Parikka M, Heinäniemi M, Lohi O. Generation of a Zebrafish Knock-In Model Recapitulating Childhood ETV6::RUNX1-Positive B-Cell Precursor Acute Lymphoblastic Leukemia. Cancers (Basel). 2023 Dec 13;15(24):5821. doi: 10.3390/cancers15245821. PMID: 38136366; PMCID:
PMC10871125.

Krali O, Marincevic-Zuniga Y, Arvidsson G, Enblad AP, Lundmark A, Sayyab S, Zachariadis V, Heinäniemi M, Suhonen J, Oksa L, Vepsäläinen K, Öfverholm I, Barbany G, Nordgren A, Lilljebjörn H, Fioretos T, Madsen HO, Marquart HV, Flaegstad T, Forestier E, Jónsson ÓG, Kanerva J, Lohi O, Norén-Nyström U, Schmiegelow K, Harila A, Heyman M, Lönnerholm G, Syvänen AC, Nordlund J. Multimodal classification of molecular subtypes in pediatric acute lymphoblastic leukemia. NPJ Precis Oncol. 2023 Dec 8;7(1):131. doi: 10.1038/s41698-023-00479-5. PMID: 38066241; PMCID: PMC10709574.

Laukkanen S, Veloso A, Yan C, Oksa L, Alpert EJ, Do D, Hyvärinen N, McCarthy K, Adhikari A, Yang Q, Iyer S, Garcia SP, Pello A, Ruokoranta T, Moisio S, Adhikari S, Yoder JA, Gallagher K, Whelton L, Allen JR, Jin AH, Loontiens S, Heinäniemi M, Kelliher M, Heckman CA, Lohi O, Langenau DM. Therapeutic targeting of LCK tyrosine kinase and mTOR signaling in T-cell acute lymphoblastic leukemia. Blood. 2022 Oct 27;140(17):1891-1906. doi: 10.1182/blood.2021015106. PMID: 35544598; PMCID: PMC10082361.

Mehtonen J, Teppo S, Lahnalampi M, Kokko A, Kaukonen R, Oksa L, Bouvy-Liivrand M, Malyukova A, Mäkinen A, Laukkanen S, Mäkinen PI, Rounioja S, Ruusuvuori P, Sangfelt O, Lund R, Lönnberg T, Lohi O, Heinäniemi M. Single cell characterization of B-lymphoid differentiation and leukemic cell states during chemotherapy in ETV6-RUNX1-positive pediatric leukemia identifies drug-targetable transcription factor activities. Genome Med. 2020 Nov 20;12(1):99. doi: 10.1186/s13073-020-00799-2. PMID: 33218352; PMCID: PMC7679990.


Start time: 08/05/2024 15:00
End time: 08/05/2024 16:00
Duration:
Location: remotely
Type: Webinar
Organization: Finnish Cancer Center (FICAN)
Contact person: anne.kairenius@hus.fi
Further information: https://research.tuni.fi/hematology-and-oncology/about-us/
Online meeting link: https://teams.microsoft.com/l/meetup-join/19%3ameeting_YWUzODBkNDQtZTdjMi00MGIzLTg1YjgtNjBlNjI3MWYyODY3%40thread.v2/0?context=%7b%22Tid%22%3a%22fa6944af-cc7c-4cd8-9154-c01132798910%22%2c%22Oid%22%3a%22e2d13f14-154c-4b47-9851-4e6e449f6a8c%22%7d