Events

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February 06

Dosentin arvon hakijoiden opetusnäytteet

Dosentin arvoa hakeneet antavat hakemuksen yhteydessä opetusnäytteen. Opetusnäytteet ovat avoimia tilaisuuksia tiedekuntalaisille ja opiskelijoille. Lämpimästi tervetuloa!

Ohjelma:

12.00-12:30 Filosofian tohtori Natalia Skogberg (kansanterveystiede) aihe: Ethnic gap in health in Finland; kohderyhmänä: TtM ja lääketieteen opiskelijat.

 

12.30-15.20 Tauko

 

15.20-15.50 Lääketieteen tohtori Markus Haapanen (kokeellinen geriatria) aihe: Miksi Seija paranee nopeammin kuin Irma?; kohderyhmänä: Yleistä hauraudesta ja sen keski-iän aikaisista riskitekijöistä.



Start time: 06/02/2024 12:00
End time: 06/02/2024 15:00
Duration: 3 hours
Location: remotely
Type: Docententship lecture
Organization: UH, Faculty of Medicine
Contact person: avvi.korjo@helsinki.fi
Further information:
Online meeting link: https://helsinki.zoom.us/j/67235922289?pwd=N2didVZkRGRDUGdWTU9IMVoyckV5Zz09
February 07

iCAN science seminar: Fibroblast heterogeneity in gastrointestinal homeostasis and tumorigenesis

Welcome to the first of the iCAN science seminars in 2024!

 

Saara Ollila, Docent, PhD from the University of Helsinki, will give a talk Fibroblast heterogeneity in gastrointestinal homeostasis and tumorigenesis on Wed, Feb 7 at 13:30 – 14:30 in Biomedicum 1, seminar room 1-2 and online. 

 

Minibio: Saara Ollila did her PhD in University of Helsinki, studying variants of unknown significance in LynchSyndrome in the laboratory of professor Minna Nyström. She was trained as a postdoctoral researcher in Tomi Mäkelä’slab in UH in Timothy Wang lab in Columbia University Medical Center, studying the role of stromal cells in regulating gastrointestinal tumorigenesis. Currently, she is an Academy Research Fellow and group leader at Translational Cancer Medicine research program atUH. Her group studies the role of mesenchymal cells in regulating gastrointestinal homeostasis,regeneration and tumorigenesis.

 

Coffee and pulla will be served prior to the seminar, so do come in time to catch up with colleagues!


Start time: 07/02/2024 13:30
End time: 07/02/2024 14:30
Duration:
Location: Biomedicum 1, seminar room 1-2
Type: Seminar
Organization: iCAN Flagship Team
Contact person: ican@helsinki.fi
Further information: https://ican.fi/news-events/ican-science-seminar-continues-on-feb-7-with-saara-ollila/
Online meeting link: https://helsinki.zoom.us/j/64804986682?pwd=ME8rOVhucnQ5YXE1VVdpck5BN25BZz09
February 09

Dissertation: Anna Ojala

Anna Ojala, University of Helsinki, Faculty of Medicine, Doctoral Program in Clinical Research
Subclinical thyroid dysfunction and quality of life : Longterm outcome for older people with stable cardiovascular disease

Opponent: Professor Georg Brabant, University of Luebeck, Germany


Start time: 09/02/2024 13:00
End time: 09/02/2024 15:00
Duration: 2 hours
Location: Biomedicum1, lecture hall 3, Haartmaninkatu 8, 00290 Helsinki
Type: Dissertation
Organization: UH, Faculty of Medicine
Contact person: anna.k.ojala@helsinki.fi
Further information: https://helda.helsinki.fi/items/05fd9e2d-e9da-4d1b-9a0e-633a07049529
Online meeting link:
February 12

ONCOSYS Special seminar: Xin Lai

Cooperative MicroRNA Therapeutics in Cancer

Xin Lai, Ph.D., Systems and Network Medicine Lab, Faculty of Medicine and Health Technology, Tampere University, Finland

Abstract
MicroRNAs (miRNAs) are short, non-coding RNAs that regulate gene expression at the post-transcriptional level. A miRNA can potentially bind many mRNAs, thereby affecting cancer genes and the activity of relevant pathways. miRNA therapeutics can harness this evolutionarily conserved mechanism for the coordinated gene regulation and thus restoring normal phenotypes in cancer cells. However, the promiscuous binding of miRNAs can provoke off-target effects caused by high-dose treatments. Hence, it is desirable to develop miRNA therapeutics with increased specificity and efficacy. To achieve that, we propose the concept of miRNA cooperativity to exert synergistic repression on target genes, thus reducing the undesired effects of miRNAs. We demonstrate the effectiveness of cooperating miRNAs in reducing the chemoresistance of tumors and improving the immunogenic potency of dendritic cells for immunotherapy. Our work shows the potential of miRNAs as monotherapy or adjuvant therapy in cancer.
 
Relevant publications
•             Lai X, Dreyer F, Cantone M, Eberhardt M, Gerer K, Jaitly T, Uebe S, Lischer C, Ekici A, Wittmann, J, Jäck HM, Schaft N, Dörrie J, Vera J. Network- and systems-based re-engineering of dendritic cells with non-coding RNAs for cancer immunotherapy. Theranostics. 2021;11(3)1412-1428. doi:10.7150/thno.53092
•             Lai X, Eberhardt M, Schmitz U, Vera J. Systems biology-based investigation of cooperating microRNAs as monotherapy or adjuvant therapy in cancer. Nucleic Acids Research 2019;47 (15):7753-7766. doi: 10.1093/nar/gkz638
•             Lai X, Gupta SK, Schmitz U, Marquardt S, Knoll S, Spitschak A, Wolkenhauer O, Pützer BM, Vera J. MiR-205-5p and miR-342-3p cooperate in the repression of the E2F1 transcription factor in the context of anticancer chemotherapy resistance. Theranostics. 2018;8(4):1106-1120. doi:10.7150/thno.19904
•             Schmitz U, Lai X, Winter F, Wolkenhauer O, Vera J, Gupta SK. Cooperative gene regulation by microRNA pairs and their identification using a computational workflow. Nucleic Acids Research. 2014;42(12):7539-7552. doi:10.1093/nar/gku465
•             Lai X, Schmitz U, Gupta SK, Bhattacharya A, Kunz M, Wolkenhauer O, Vera J. Computational analysis of target hub gene repression regulated by multiple and cooperative miRNAs. Nucleic Acids Research. 2012;40(18):8818-8834. doi:10.1093/nar/gks657



Start time: 12/02/2024 12:15
End time: 12/02/2024 13:00
Duration: 45 minutes
Location: Biomedicum1, lecture hall 2, Haartmaninkatu 8, 00290 Helsinki
Type: Seminar
Organization: UH, Faculty of Medicine
Contact person: karen.ahlnas@helsinki.fi
Further information:
Online meeting link:
February 14

Biostatistics drop-in workshop

Are you a researcher needing support with any statistical aspect of your work? The Biostatistics Consulting Service here at Meilahti Campus holds drop-in workshop sessions every other week to answer smaller questions about your analysis - solving a particular problem, how to get started, etc. We provide service in Finnish, English and Swedish.

 

The next workshop is on Wednesday 14th February, at 13:00-15:00 in Biomedicum 2B, in the Olohuone on floor 6. Come whenever you can. Note that you may end up waiting a while for your turn, especially early on in the session. We aim to spend no more than 15 minutes with each customer.

 

Bring: 

·       your computer

·       your data

·       your questions

and we biostatisticians will be on hand to help and guide. 

 

Registration is not required, but you can help us prepare for your questions by filling in this form. The workshops are open to any researcher at the university's Medical Faculty, HUS or FIMM.

Sessions are planned to continue roughly every other week throughout the spring: 14.2, 28.2, 20.3 (note 3-week interval), 3.4, 17.4, etc.

 

For more in-depth questions, please book a one-on-one consultation session using this e-form where we will have time to go into more detail. 

 

From the Biostatistics Team


Start time: 14/02/2024 13:00
End time: 14/02/2024 15:00
Duration: 2 hours
Location: Biomedicum 2, 6th floor lounge
Type: Other
Organization: Biostatistics Consulting Service
Contact person: biostat-consult@helsinki.fi
Further information: https://www.helsinki.fi/en/infrastructures/biostatistics-unit/consulting
Online meeting link: