Events

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January 24

Dissertation: Aki Ronkainen

Aki Ronkainen, University of Helsinki, Faculty of Medicine, Doctoral Programme in Biomedicine
Bifidobacterium strains from donors of fecal microbiota transplantation : Colonization patterns and therapeutic prospects

Opponent: docent Antti Hakanen, University of Turku



Start time: 24/01/2025 12:00
End time: 24/01/2025 14:00
Duration: 2 hours
Location: Naistenklinikka, Seth Wichmann -sali, Haartmaninkatu 2
Type: Dissertation
Organization: UH, Faculty of Medicine
Contact person: aki.ronkainen@helsinki.fi
Further information: https://helda.helsinki.fi/items/b481ff57-9c84-4d1a-b7ba-ce2f42b62092
Online meeting link:
January 24

Dissertation: Maria Jauhiainen

Maria Jauhiainen, University of Helsinki, Faculty of Medicine, Doctoral Program in Clinical Research
Investigations on viral etiology of head and neck neoplasms

Opponent: Romain Kania, Lariboisière University Hospital and Paris Cité University



Start time: 24/01/2025 13:00
End time: 24/01/2025 15:00
Duration: 2 hours
Location: Kirurginen sairaala, Richard Faltin Luentosali, Kasarmikatu 11-13
Type: Dissertation
Organization: UH, Faculty of Medicine
Contact person: maria.k.jauhiainen@helsinki.fi
Further information: https://helda.helsinki.fi/items/ab1332ec-b7b7-4c7f-a45b-d9f066bdb0f6
Online meeting link:
January 27

Wihuri Research Institute Special Seminar by Dr. Bong-Ihn Koh

Functional specialization of cranial tissues: Lessons from blood vessels

Speaker: Dr. Bong-Ihn Koh Max Planck Institute for Molecular Biomedicine, Münster

Dr. Bong-Ihn Koh’s research focuses on understanding how the bone marrow microenvironment regulates hematopoietic stem cell self-renewal and fate. Although aging, chronic inflammation, and other insults compromise bone marrow function, it is not known whether different bone compartments exhibit distinct microenvironmental properties and functional resilience.

Dr. Koh will present his recent discoveries on the functional specialization of blood vessels in the skull bone marrow and the dura mater of the neighboring meninges. His findings reveal that the skull bone marrow unexpectedly undergoes lifelong expansion involving vascular growth, which results in an increasing contribution to total hematopoietic output and is largely protected against major hallmarks of aging. The underlying mechanisms of this process, as well as the rapid and complete vascular regeneration potential of the neighboring dura mater, will be discussed. He will also provide an overview of unique vascular channels, which physically connect these tissues, facilitating specialized immune functions in various pathophysiological conditions.
Selected publications
Koh BI#, Mohanakrishnan V, Jeong HW, Park H, Kruse K, Choi YJ, Nieminin-Kelhä M, Kumar R, Pereira RS, Adams S, Lee HJ, Bixel MG, Vajkoczy P, Krause DS, Adams RH# (2024) Adult skull bone marrow is an expanding and resilient hematopoietic reservoir. Nature. 636:172- 181. (#, co-corresponding author)

Liu Y, Chen Q, Jeong HW, Koh BI, Watson EC, Xu C, Stehling M, Zhou B, Adams RH (2022) A specialized bone marrow microenvironment for fetal hematopoiesis. Nat Commun. 13(1):1327.

Koh BI, Lee HJ, Kwak P, Yang MJ, Kim JH, Kim HS, Koh GY, Kim I (2020) VEGFR2 signaling drives meningeal vascular regeneration upon head injury. Nat Commun. 11(1):3866.

Park D, Spencer JA, Koh BI, Kobayashi T, Fujisaki J, Clemens TL, Lin CP, Kronenberg HM, Scadden DT (2012) Endogenous bone marrow MSCs are dynamic, fate-restricted participants in bone maintenance and regeneration. Cell Stem Cell. 2012 10:259-72.

Koh YJ, Koh BI*, Kim H, Joo HJ, Jin HK, Jeon J, Choi C, Lee DH, Chung JH, Cho CH, Park WS, Ryu JK, Suh JK, Koh GY (2011) Stromal vascular fraction from adipose tissue forms profound vascular network through the dynamic reassembly of blood endothelial cells. Arterioscler Thromb Vasc Biol. 31:1141-50. (*, co-first author)

Please contact Prof. Taija Mäkinen (taija.makinen@helsinki.fi) or Prof. Kari Alitalo (kari.alitalo@helsinki.fi) if you wish to discuss with Dr. Koh after his talk.



Start time: 27/01/2025 13:00
End time: 27/01/2025 14:00
Duration: 1 hour
Location: Aurora Hall 230, Siltavuorenpenger 10, Helsinki
Type: Seminar
Organization: Wihurin tutkimuslaitos
Contact person: taija.makinen@helsinki,fi
Further information:
Online meeting link:
January 27

ReproducibiliTea: Statistical Insights into reliable research

EVENT DETAILS

About the guest

Hanna Granroth-Wilding is an experienced biostatistician with a primary research background. Having completed her PhD at the University of Edinburgh, she continued her postdoctoral research in the UK and Finland, most recently at the University of Helsinki in the behavioral ecology group. After a spell in the energy industry, she now works at the Medical Faculty's Biostatistics Consulting Service, supporting researchers across the campus with statistical quandaries from planning through implementation to write-up and review.

 

What?

This month's pick is a more technical paper on pseudoreplication in neuroscience.  We ask you to focus on the general idea of the paper without sweating too much over specific numbers and cases. Do not be intimidated if there are any unknown statistical terms or techniques. Rather, bring the unknowns and questions to the discussion!

 

Name: Lazic SE. The problem of pseudoreplication in neuroscientific studies: is it affecting your analysis? BMC Neurosci. 2010 Jan 14;11:5. doi: 10.1186/1471-2202-11-5. PMID: 20074371; PMCID: PMC2817684.

 

See HERE for pdf version.

Please submit your registration before the event HERE. The registration is not binding. It will only be used to estimate amounts of food and drinks. So do come over even if you didn't register!



Start time: 27/01/2025 14:00
End time: 27/01/2025 16:00
Duration: 1 hour
Location: Biomedicum Helsinki 1, meeting room Skutsi
Type: Other
Organization: UH, Faculty of Medicine
Contact person: grp-reproducibilitea@helsinki.fi
Further information: https://reproducibilitea.org/journal-clubs/#UniHelsinki
Online meeting link:
January 28

3D Proteomics for Single Cells - Novel Insights in Immunology and Cancer Enabled by Molecular Pixelation 3D Proteomics

3D Proteomics for Single Cells - Novel Insights in Immunology and Cancer Enabled by Molecular Pixelation 3D Proteomics


Discover how Molecular Pixelation has been used to uncover cancer-specific phenotypes in hematological malignancies and CAR-T cell functionality  and efficency. 


Speaker: Louise Leijonancker, Field Application specialist, Pixelgen technologies

The seminar will be followed by a Q&A session, where you will have the opportunity to engage with the speaker and ask any questions related to the topic.


Start time: 28/01/2025 01:00
End time: 28/01/2025 12:00
Duration: 11 hours
Location: Biomedicum 1, seminar room 1-2
Type: Seminar
Organization: FIMM
Contact person: jenni.lahtela@helsinki.fi
Further information: https://www.pixelgen.com/.
Online meeting link: https://us06web.zoom.us/j/89214155132?pwd=M1jK1WHeeGyYomZ28XU6WdtfpqNYo5.1