Events

June 09

Dissertation: Aini Hyytiäinen

​Aini Hyytiäinen, University of Helsinki, Faculty of Medicine, Department of oral and maxillofacial diseases, Doctoral Program in Clinical Research
Towards more effective use of radiotherapy for treating head and neck squamous cell carcinoma patients

Opponent: docent Tero Soukka, University ofTurku


Start time: 09/06/2023 13:00
End time: 09/06/2023 15:00
Duration: 2 hours
Location: Biomedicum1, lecture hall 3, Haartmaninkatu 8, 00290 Helsinki
Type: Dissertation
Organization: UH, Faculty of Medicine
Contact person: aini.hyytiainen@helsinki.fi
June 12

CancerBio Summer School and HiLIFE Special seminar by Andrei Goga

Building a Better Cancer: Understanding Mechanisms that Drive the Growth and Metastasis of Aggressive Tumors
 
Andrei Goga is a renowned scientist and medical oncologist who has made significant contributions to the field of cancer research. He received his Bachelor's degree in Cell and Molecular Biology from the University of California, Los Angeles in 1990, followed by an MD and Ph.D in Medicine and Molecular Biology from the same university in 1997. Dr. Goga underwent residency training in internal medicine and fellowship in medical oncology at the University of California, San Francisco from 1997 to 2003. During his PhD and post-doctoral research, he received scientific training in the laboratories of Dr. Owen Witte, Dr. David Morgan, and Dr. J. Michael Bishop, where he studied various aspects of BCR-ABL oncogene signaling pathways and cell cycle deregulation in MYC-driven cancers.
Since 2007, Dr. Goga has been leading an independent lab at the University of California, San Francisco, where he is both a practicing medical oncologist and a basic investigator. Goga lab's primary research goal is to develop new cancer therapies by targeting oncogene signaling pathways for cancer therapy. Through the use of various model systems, Goga lab seeks to understand how oncogenes reprogram the cell cycle, small RNAs, and metabolism to drive tumorigenesis and metastasis. Andrei's lab also focuses on identifying novel tumor vulnerabilities and developing anti-cancer therapeutics based on this knowledge.
 
Dr. Goga current serves as a Co-Leader of the UCSF Breast Oncology Program of the UCSF Comprehensive Cancer Center.  He is also serves as Vice-Chair of the UCSF Department of Cell and Tissue Biology. Overall, Andrei's expertise and research continues to pave the way for the development of effective and innovative cancer therapies.
 
Awards and Achievements
 
Andrei Goga is a distinguished scholar who has received awards from various organizations for his research, including the Susan G. Komen Foundation, the Leukemia Lymphoma Society, and CDMRP Breast Cancer Research Program – Era of Hope award. In the past, he has also received funding from the Program in Breakthrough Biological Research (PBBR), V-Foundation, Leukemia, Lymphoma Society (LLS), and Gallo Family Foundation, and ACS Pilot for his research.
Currently, Andrei Goga's research is supported by various organizations, including the NIH/NCI, Atwater Foundation, Breast Cancer Research Foundation, Gazarian Family Foundation, and CDMRP BCRP.
 
Selected Publications:
 
Camarda R, Zhou AY, Kohnz RA, Balakrishnan S, Mahieu C, Anderton B, Eyob H, Kajimura S, Tward A, Krings G, Nomura DK, Goga A. Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer. Nat Med. 2016 Apr; 22(4):427-32. PMID: 26950360.
 
Lawson DA, Bhakta NR, Kessenbrock K, Prummel KD, Yu Y, Takai K, Zhou A, Eyob H, Balakrishnan S, Wang CY, Yaswen P, Goga A*, Werb Z*. Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells. Nature. 2015 Oct 1; 526(7571):131-5. PMID: 26416748.  *Co-Corresponding
 
Horiuchi D, Camarda R, Zhou AY, Yau C, Momcilovic O, Balakrishnan S, Corella AN, Eyob H, Kessenbrock K, Lawson DA, Marsh LA, Anderton BN, Rohrberg J, Kunder R, Bazarov AV, Yaswen P, McManus MT, Rugo HS, Werb Z, Goga A. PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression. Nat Med. 2016 Nov; 22(11):1321-1329. PMID: 27775705.
 
Rohrberg J, Van de Mark D, Amouzgar M, Lee JV, Taileb M, Corella A, Kilinc S, Williams J, Jokisch ML, Camarda R, Balakrishnan S, Shankar R, Zhou A, Chang AN, Chen B, Rugo HS, Dumont S, Goga A.  MYC Dysregulates Mitosis, Revealing Cancer Vulnerabilities. Cell Rep. 2020 Mar 10;30(10):3368-3382.e7.
 
Kilinc S, Paisner R, Camarda R, Gupta S, Momcilovic O, Kohnz RA, Avsaroglu B, L'Etoile ND, Perera RM, Nomura DK, Goga A. Oncogene Regulated Release of Extracellular Vesicles. Dev Cell. 2021 Jul 12;56(13):1989-2006.e6. PMID: 34118203
 
Lee JV, Housley F, Yau C, Nakagawa R, Winkler J, Anttila JM, Munne PM, Savelius M, Houlahan KE, Van de Mark D, Hemmati G, Hernandez GA, Zhang Y, Samson S, Baas C, Esserman LJ, van 't Veer LJ, Rugo HS, Curtis C, Klefström J, Matloubian M, Goga A. Combinatorial immunotherapies overcome MYC-driven immune evasion in triple negative breast cancer. Nat Commun. 2022 Jun 27; 13(1):3671. PMID: 35760778.
Navickas A, Asgharian H, Winkler J, Fish L, Garcia K, Markett D, Dodel M, Culbertson B, Miglani S, Joshi T, Yin K, Nguyen P, Zhang S, Stevers N, Hwang HW, Mardakheh F, Goga A, Goodarzi H. An mRNA processing pathway suppresses metastasis by governing translational control from the nucleus. Nat Cell Biol. 2023 May 8. doi: 10.1038/s41556-023-01141-9. Epub ahead of print. PMID: 37156909.
Coming Soon - Manuscripts available at bioRxiv:

Camarda, R., Williams, J. B., Malkov, S., Zimmerman, L. J., Manning, S., Aran, D., Beardsley, A., Van De Mark, D., Chen, Y., Berdan, C. A., Louie, S. M., Mahieu, C., Winkler, J., Willey, E., Gagnon, J. H., Shinoda, K., Ansel, K. M., Werb, Z., Nomura, D. K., . . . Goga, A. (2018). Tumor cell-adipocyte gap junctions activate lipolysis and are essential for breast tumorigenesis. bioRxiv. https://doi.org/10.1101/277939
 
Winkler, J., Tan, W., Diadhiou, C. M., McGinnis, C. S., Abbasi, A., Hasnain, S., Durney, S., Atamaniuc, E., Superville, D., Awni, L., Lee, J. M., Hinrichs, J. H., Hein, M. Y., Borja, M. J. B., Detweiler, A. M., Liu, S., Nanjaraj, A., Sitarama, V., Rugo, H. S., . . . Werb, Z. (2022). Dissecting the contributions of tumor heterogeneity on metastasis at single-cell resolution. bioRxiv. https://doi.org/10.1101/2022.08.04.502697

Find out more information on Professor Goga’s research and recent publications: 

https://www.oncogenes.net/

Twitter @goga_lab 

We welcome you to this exciting seminar!

Host: Juha Klefström

Student host: July Aung 

CancerBio Summer School Organizing Committee 

Juha Klefström,

July Aung, Ylva von Wright, Kim Le, Victor Arias, Leticia Castillon, Kerttu Kalander, Tatiana Kudling, James Clubb 

HiLIFE Seminars Coordinating Team

Leonardo Almeida-Souza, Jaan-Olle Andressoo, Anna Vähärautio, Anu Luoto



Start time: 12/06/2023 12:00
End time: 12/06/2023 13:00
Duration:
Location: Biomedicum1, lecture hall 2, Haartmaninkatu 8, 00290 Helsinki
Type: Seminar
Organization: Helsinki Institute of Life Science HiLIFE
Contact person: juha.klefstrom@helsinki.fi
June 13

iCAN science seminar: Doga C Gulhan

Pan-cancer immunogenomic landscape of homologous recombination deficiency


Doga Gulhan is a postdoctoral fellow at the Department of Biomedical Informatics at Harvard Medical School. She develops computational tools to decode patterns of mutations through signature analysis. The SigMA algorithm she developed enables the application of this technique in routine clinical genome sequencing with targeted panels. SigMA identifies the signature of homologous recombination deficiency and can be used to expand the patient population who may benefit from PARP inhibitors. Her recent work focuses on characterizing different types of genomic instability and constructing novel genomic biomarkers for targeted and immuno-therapies using liquid and solid biopsies.

Learn more about the speaker.


Please note, that the event is organised as a webinar only. Join with the link below!


Start time: 13/06/2023 14:00
End time: 13/06/2023 15:00
Duration:
Location: remotely
Type: Webinar
Organization: iCAN Flagship Team
Contact person: ican@helsinki.fi
June 14

Special seminar: Prof Noelle L'etoile

Sleep is required for odor exposure to consolidate memory and remodel olfactory synapses

The L'etoile Lab investigates how neurons perceive and transmit information both in response to novel and persistent environmental cues. We use the nematode C. elegans because its neuronal circuitry is completely described, and exhibits robust plasticity. C. elegans also allows us to use powerful cell biological, genetic, behavioral, physiological and molecular techniques to study plasticity. For example, we discovered a pathway in which nuclear translocation of a kinase and small RNAs modify chromatin, which allows environmental cues to sculpt long-term behavior. Our research may inform understanding of normal processes such as learning and memory as well as elucidate what goes awry in disease states such as addiction.

 

https://ctb.ucsf.edu/people

https://www.letoilelab.net/ 

Publications:

https://www.letoilelab.net/publications

 

Master student/PhD/ Post doc: Do you wish to meet Professor L'etoile during a student lunch after the lecture 11-12 am. (max 24 persons)?


Please sign up for henna-kaisa.wigren@helsinki.fi latest by June 5th.



Start time: 14/06/2023 10:00
End time: 14/06/2023 11:00
Duration: 1 hour
Location: Biomedicum1, lecture hall 2, Haartmaninkatu 8, 00290 Helsinki
Type: Seminar
Organization: SLEEPWELL Research Program
Contact person: henna-kaisa.wigren@helsinki.fi
June 16

Dissertation: Elias Oulasvirta

​Elias Oulasvirta, University of Helsinki, Faculty of Medicine, Doctoral Program in Clinical Research
Pediatric Brain Arteriovenous Malformations

Opponent: professor Veit Rohde, Göttingen University Hospital Neurosurgery Clinic


Start time: 16/06/2023 12:00
End time: 16/06/2023 14:00
Duration: 2 hours
Location: HUS SIltasairaala, Töölö luentosali STB3.03, Haartmaninkatu 4
Type: Dissertation
Organization: UH, Faculty of Medicine
Contact person: elias.oulasvirta@hus.fi