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September 29

Dissertation: Kristen Kurtzeborn

Kristen Kurtzeborn,  University of Helsinki, Faculty of Medicine, Doctoral Programme in Biomedicine
Cellular and molecular regulation of renal progenitor populations : The roles of receptor tyrosine kinase signaling in nephron and collecting duct progenitor maintenance and differentiation

Opponent: Professor Melissa Little, Murdoch Children's Research Institute and University of Melbourne



Start time: 29/09/2023 12:00
End time: 29/09/2023 14:00
Duration: 2 hours
Location: Biomedicum1, lecture hall 3, Haartmaninkatu 8, 00290 Helsinki
Type: Dissertation
Organization: UH, Faculty of Medicine
Contact person: kristen.kurtzeborn@helsinki.fi
Further information: https://helda.helsinki.fi/items/217ab32b-1c32-4609-96ef-f872d7b68211
Online meeting link:
September 29

Dissertation: Elina Rancken

Elina Rancken,  University of Helsinki, Faculty of Medicine, Doctoral Program in Clinical Research, Department of Pediatric Neurology

Helsinki University Hospital, Children's Hospital, Department of Pediatric Neurology, Pediatric Research Center
Perinatal asphyxia: Apgar scores and umbilical blood biomarkers in predicting neurodevelopmental outcome

Opponent: docent Hanna Soukka, University of Turku


Start time: 29/09/2023 12:00
End time: 29/09/2023 14:00
Duration: 2 hours
Location: Uusi lastensairaala, Hattivatti -sali, Stenbäckinkatu 9, Helsinki
Type: Dissertation
Organization: UH, Faculty of Medicine
Contact person: elina.rancken@helsinki.fi
Further information: https://helda.helsinki.fi/items/a79cdb2a-4966-44b5-8fd2-d1baf11ef0a0
Online meeting link:
September 29

Dissertation: Benjamin Sundqvist

Benjamin Sundqvist, University of Helsinki, Faculty of Medicine, Doctoral Programme in Biomedicine
Clues to Cellular Ancestry and Novel Biomarkers in Merkel Cell Carcinoma

Opponent: Professor Axel zur Hausen, Maastricht University



Start time: 29/09/2023 13:00
End time: 29/09/2023 15:00
Duration: 2 hours
Location: Haartman Institute, lecture hall 2, Haartmaninkatu 3, 00290 Helsinki
Type: Dissertation
Organization: UH, Faculty of Medicine
Contact person: benjamin.sundqvist@helsinki.fi
Further information: https://helda.helsinki.fi/items/10b34815-eb6f-42f7-96ea-5c35ae81d21f
Online meeting link:
September 29

Dissertation: Juho Pirhonen

Juho Pirhonen, University of Helsinki, Faculty of Medicine, Doctoral Programme in Biomedicine
Mechanisms of lipid deposition - application of novel omics techniques, tissue imaging methods, and their synergistic deployment in lipid research

Opponent: professor Pekka Taimen, Univeristy of Turku



Start time: 29/09/2023 13:00
End time: 29/09/2023 15:00
Duration: 2 hours
Location: University of Helsinki main building, Fabianinkatu 33, Helsinki
Type: Dissertation
Organization: UH, Faculty of Medicine
Contact person: juho.h.pirhonen@gmail.com
Further information: https://helsinginyliopisto.etapahtuma.fi/kalenteri/suomi.aspx#.YMGqz6gzZPY
Online meeting link:
October 02

HiLIFE webinar / Viikki Monday Seminar Hans-Georg Kräusslich

The HIV-1 capsid as orchestrator of early replication  
Hans-Georg Kräusslich graduated from Medical School in Munich completed his doctoral thesis on viral protein processing in 1985. He then did a postdoc on poliovirus at State University of New York at Stony Brook. In 1989, he established his own group at the German Cancer Research Center in Heidelberg working on assembly and replication of HIV. In 1995, he became full professor and Head of Department at the Heinrich-Pette-Institute in Hamburg, directing the Institute from 1996 to 1999. Since 2000, he has been the Head of Virology at Heidelberg University and since 2003 Director of the Department of Infectious Diseases. Currently he is the Dean of the Medical Faculty and coordinates a DFG Comprehensive Research Center on “Integrative Analysis of Pathogen Replication and Spread”. His contribution includes ~250 papers in international, peer-reviewed journals.
His research focuses on different aspects of retroviral biology, especially the formation and architecture of human immunodeficiency virus, the role of lipids in virus entry and egress, and the role of innate immunity during virus infection.
 
PhD students and postdocs are invited to sign up for lunch with the speaker (first 5 to contact me). If you would like to meet the speaker in Viikki on Monday, please let me know.
Welcome to this exciting seminar!  
Sarah Butcher
 
Selected publications:
Zila V, Margiotta E, Turoňová B, Müller TG, Zimmerli CE, Mattei S, Allegretti M, Börner K, Rada J, Müller B, Lusic M, Kräusslich HG, Beck M. (2021) Cone-shaped HIV-1 capsids are transported through intact nuclear pores. Cell 184(4):1032-1046.e18. doi: 10.1016/j.cell.2021.01.025.
Müller TG, Zila V, Peters K, Schifferdecker S, Stanic M, Lucic B, Laketa V, Lusic M, Müller B, Kräusslich HG. (2021) HIV-1 uncoating by release of viral cDNA from capsid-like structures in the nucleus of infected cells. Elife 10:e64776. doi: 10.7554/eLife.64776
Zila V. Müller TG, Müller B, Kräusslich HG. (2021) HIV-1 capsid is the key orchestrator of early viral replication. PLoS Path. 17(12):e1010109. doi: 10.1371/journal.ppat.1010109. (review)
Qu K, Ke Z, Zila V, Anders-Össwein M, Glass B, Mücksch F, Müller R, Schultz C, Müller B, Kräusslich HG, Briggs J. (2021) HIV-1 uncoating by release of viral cDNA from capsid-like structures in the nucleus of infected cells. Science 373: 700-704. DOI: 10.1126/science.abe6821
Ke Z, Oton J, Qu K, Cortese M, Zila V, McKeane L, Nakane T, Zivanov J, Neufeldt CJ, Cerikan B, Lu JM, Peukes J, Xiong X, Kräusslich HG, Scheres SHW, Bartenschlager R, Briggs JAG. (2021) Structures and distributions of SARS-CoV-2 spike proteins on intact virions. Nature 588(7838):498-502. doi: 10.1038/s41586-020-2665-2.
Zila V, Müller TG, Laketa V, Müller B, Kräusslich HG. (2019) Analysis of CA Content and CPSF6 Dependence of Early HIV-1 Replication Complexes in SupT1-R5 Cells. mBio. 10(6):e02501-19. doi: 10.1128/mBio.02501-19.
Bejarano DA, Peng K, Laketa V, Börner K, Jost KL, Lucic B, Glass B, Lusic M, Müller B, Kräusslich HG. (2019) HIV-1 nuclear import in macrophages is regulated by CPSF6-capsid interactions at the nuclear pore complex. Elife. 8:e41800. doi: 10.7554/eLife.41800.
Sakin V, Hanne J, Dunder J, Anders-Össwein M, Laketa V, Nikić I, Kräusslich HG, Lemke EA, Müller B. 2017. A Versatile Tool for Live-Cell Imaging and Super-Resolution Nanoscopy Studies of HIV-1 Env Dis-tribution and Mobility. Cell Chem Biol. 24(5):635-645.e5. doi: 10.1016/j.chembiol.2017.04.007
Mattei S, Glass B, Hagen WJ, Kräusslich HG, Briggs JA. 2016. The structure and flexibility of conical HIV-1 capsids determined within intact virions. Science. 2016 Dec 16;354(6318):1434-1437
Hanne J, Göttfert F, Schimer J, Anders-Össwein M, Konvalinka J, Engelhardt J, Müller B, Hell SW, Kräuss-lich HG. 2016a. Stimulated Emission Depletion Nanoscopy Reveals Time-Course of Human Immunodeficiency Virus Proteolytic Maturation. ACS Nano. 10(9):8215-22
Schur FKM, Obr M, Hagen W, Wan W, Jakobi AJ, Kirkpatrick JM, Sachse C, Kräusslich HG, Briggs JAG. 2016 An atomic model of HIV-1 capsid-SP1 reveals structures regulating assembly and maturation. Sci-ence 353 (6298), 506-508
Peng K, Muranyi W., Glass B, Laketa V, Yant SR, Tsai L, Cihlar T, Müller B, Kräusslich HG. 2014. Quantita-tive microscopy of functional HIV post-entry complexes reveals association of replication with the viral capsid. eLife 10.7554/eLife.04114


Start time: 02/10/2023 13:00
End time: 02/10/2023 14:00
Duration: 1 hour
Location: Biocenter 1, Lecture Hall1401, Viikinkaari 9,
Type: Seminar
Organization: Helsinki Institute of Life Science HiLIFE
Contact person: hilife-seminars@helsinki.fi
Further information: https://www.helsinki.fi/en/hilife-helsinki-institute-life-science/research/hilife-life-science-seminars/hilife-webinars
Online meeting link: https://helsinki.zoom.us/j/68326277457