Biomedicum Helsinki -säätiö myöntää vuosittain apurahoja nuorille tutkijoille, kliiniselle post-doc tutkijoille sekä Startup projekteille. Lisää tietoa apurahahausta löytyy hakusivulta.
Vuosi
2025 apurahansaajat
50 000 €
Evolution of T cell reactivity against somatic mutations across human colon cancer stages with single-cell genomics and synthetic T cell specificity screening
SCGB1D2 as a Host Defense Factor and Therapeutic Target in Lyme Disease Fund: Borrelia research
6000 €
Adipose Tissue Vascular Distortion in Obesity: Mechanisms and Rescue by Incretin Agonists FUND: Cardiovascular
The influence of low-density lipoprotein lipidome on the risk of atherosclerosis in humans Fund: Cardiovascular
4000 €
The role of liquid biopsy in revealing clinical and biological heterogeneity in aggressive B-cell lymphomas FUND: Cancer and Cell Based Cancer Research
Molecular subtypes and novel serum biomarkers if gastric cancer
Ischemic stroke in the young: Long-term outcomes and the impact of psychiatric medication use FUND: Neurological and Cerebrovascular Disorder
Ex vivo drug response profiling for outcome prediction in acute myeloid leukemia (AML) – a prospective observational study FUND: Cancer and Cell Based Cancer Research
Mapping Environmental Contributors to Omic Variation in Monozygotic Twin Pairs
Understanding the effects of immune checkpoint inhibitors in treatment of AML patients with single-cell transcriptomics
The role of X chromosome in the genetics of complex traits and autoimmune diseases and sex differences within
Understanding and preventing thrombosis and bleeding in surgery and oncology FUND: Urological research
NGS based rare disease diagnostics and carrier screening
Decoding the Roles of Circulating Extracellular Vesicles in Brain-dead Donors
Uncovering ERCC6L2 Disease from Germline Defect to Bone Marrow Failure and Leukemia with Transcriptomics and Metabolomics FUND: Cancer and Cell Based Cancer Research
Computational Precision Oncology of Spatial Immune Escape Mechanisms in Ovarian Cancer FUND: Cancer and Cell Based Cancer Research
Modeling inborn errors of metabolism and developing clinically applicable gene editing tools using CRISPR base editors
Characterization of metabolic heterogeneity in normal pregnancies and gestational diabetes – early-pregnancy prognostic factors
Endothelial cell adipose depot specificity and its implications for health and metabolic disease FUND: Cardiovascular FUND: Cardiovascular
Advancing Cancer Research through Interpretable AI-driven Image Analysis
Mobile technology in the detection and treatment of main risk factors of patients with ischemic stroke or transient ischemic attack FUND: Neurological and Cerebrovascular Disorder
Pitkittyneet kokemukselliset oireet lievässä aivovammassa: Psykologisten tekijöiden ja elämäntilanteen merkitys
Genetic variation of pharmacokinetics: studies with antidiabetic and lipid-lowering drugs
Molecular background of endometriosis and the association of endometriosis with cancer FUND: Cancer and Cell Based Cancer Research
Probing the Molecular and Cellular Mechanisms Behind Thymic Abnormalities in Myasthenia Gravis: Unlocking the Origins of Autoimmunity. FUND: Neurological and Cerebrovascular Disorder
Uudet geneettiset menetelmät ja kuvantaminen luustodysplasioiden sikiödiagnostiikassa – diagnostinen osuvuus ja kliininen merkitys
Tyvisolusyövän ja Bowenin taudin uusia hoitostrategioita FUND: Cancer and Cell Based Cancer Research
AI-Driven Prognostic Models from Diagnostic Prostate MRI for Metastasis and Mortality Risk Assessment FUND: Urological research
Puutiaisvälitteisen Tribeč-viruksen esiintyvyys Etelä-Suomessa FUND: Borrelia research
Neurodegenerative Changes of the Optic Pathway and Progression of Cerebral Small Vessel Disease in Type 1 Diabetes FUND: Neurological and Cerebrovascular Disorder
The therapeutic potential of phosphodiesterase 3A modulators and their synergistic compound combinations in the treatment of soft-tissue sarcomas FUND: Cancer and Cell Based Cancer Research
Hengitysteissä syntyvät partikkelit ja yksilöllisten tekijöiden vaikutus
Epigenome-wide association study of arterial stiffness in type 1 diabetes FUND: Cardiovascular
The genetics and biomarkers of diabetic kidney disease in individuals with type 1 diabetes
Magneettikuvauksen ja magneettikolangiografian merkitys lapsuusiän primääriä sklerosoivaa kolangiittia sairastavien potilaiden diagnostiikassa, seurannassa ja ennustearviossa
Effects of alcohol exposure on embryonic and extraembryonic cells in early pregnancy
4000 €
Uncovering How Microglia Derived From Discordant Schizophrenic Twins Resist Overactivation Following Bacterial Infection
Mathematical modelling and simulation of drug combination clinical trials FUND: Cancer and Cell Based Cancer Research
Exploring potentially brain-derived RNAs in urinary extracellular vesicles
Prevalence, Type & Severity of Anemia in Newly-Diagnosed Pediatric Patients with IBD at Helsinki New Children’s Hospital (2023-2024) FUND: Marketta Helenius Fund for Health Sciences
Induction of neuroinflammation by Borrelia surface proteins FUND: Borrelia research
Oncogenic neuroplasticity of brain metastases FUND: Brain Cancer
Targeting Bcl-xL and Mic-1 in Oral Cancer: Drug Response Studies in a Human Tumor Matrix Model FUND: Cancer and Cell Based Cancer Research
Spontaneous passage of common bile duct stones
Efficacy of AI-Assisted Ambient Scribe Technology in Clinical Documentation – A Randomized Clinical Trial
Synnytyksen käynnistykseen liittyvän sensoriteknologian kehitystutkimus: Sikiön sykkeen ja supistusten mittaus kohdunkaulan kypsytyksessä käytettävän pallokatetrin avulla täysiaikaisessa raskaudessa
Accelerating pre-clinical discovery through AI-powered phenotyping.
The role of endothelial Bone marrow kinase X (Bmx) in cardiac inflammation – pressure-overload and atherosclerosis FUND: Cardiovascular
FROM STEM CELLS TO MOTOR NEURONS: THE ROLE OF MITOCHONDRIAL CONTENT DYNAMICS IN NEUROMUSCULAR DISEASE FUND: Neurological and Cerebrovascular Disorder
Investigating the functional interplay of CHCHD2 and CHCHD10 in human stem cell models of late-onset spinal muscular atrophy FUND: Neurological and Cerebrovascular Disorder
Using Generative AI for Drug Design FUND: Cancer and Cell Based Cancer Research
Closed-loop control ventilation (INTELLiVENT) of intubated patients during prehospital care – A prospective pilot study
2024 apurahansaajat
50 000 €
Delirium as a risk factor for incident institutionalization
6000 €
Kognitiivis-behavioraalinen ryhmäinterventio neuro/psykiatrisesti oireilevien lasten hoidossa
Tracing back intrinsic chemo-resistance in HGSC organoids via ReSisTrace FUND: Cancer and Cell Based Cancer Research
Hematopoietic stem cell transplantation for ERCC6L2 disease FUND: Cancer and Cell Based Cancer Research
Unraveling the disease mechanisms of spinal muscular atrophy Jokela type using multiple new disease models FUND: Neurological and Cerebrovascular Disorder
Molecular Characterization of Uterine Leiomyomas and Leiomyosarcomas Through Omics Analyses
Novel integrative analysis of cell-free DNA based features and tissue omics for Monitoring Treatment Response and Tracking Cancer Evolution in High Grade Serous Ovarian Carcinoma FUND: Cancer and Cell Based Cancer Research
High-throughput drug screening to identify enhancers of NK cell immunotherapy in advanced phase chronic myeloid leukemia
Microenvironmental stiffness regulates luminal breast cancer cell immunity and resistance FUND: Cancer and Cell Based Cancer Research
Antibody-drug conjugates in experimental models of HER2-positive gastric cancer and breast cancer with special reference to drug resistance FUND: Cancer and Cell Based Cancer Research
Molecular landscape of endometrial tumors
Ischemic Stroke during Pregnancy and Puerperium FUND: Neurological and Cerebrovascular Disorder
4000 €
Targeting primary immunotherapy resistance in non-small cell lung caner patients carrying EGFR mutation FUND: Cancer and Cell Based Cancer Research
Myomectomies: Tumor Characteristics and Clinical Implications
Revolutionizing cancer treatment by uniting oncolytic adenoviruses with T cell engagers to prevent T cell exhaustion in ovarian ascites samples FUND: Cancer and Cell Based Cancer Research
Analysis of Prox1 transcription factor in intestinal differentiation and maintenance of the tumor stem cell pool FUND: Cancer and Cell Based Cancer Research
NOVEL MECHANISTIC INSIGHTS INTO DIABETIC KIDNEY DISEASE: THE ROLE OF ADAPTOR PROTEIN PACSIN2 Fund: Urological research
Innate immune responses in viral infections: Exploring the roles of neutrophils and monocytes in vascular permeability
Prediction of selective and synergistic drug combinations in relapsed AML using single-cell transcriptomics FUND: Cancer and Cell Based Cancer Research
The critical role of antibody producing cells in regulating the anti-tumour response to oncolytic adenovirotherapy FUND: Cancer and Cell Based Cancer Research
The role of hormonal contraception in prevention of anemia in premenopausal women
Enhancing mitochondrial biogenesis to slow biological aging in human skeletal muscle
Advancing Genetic Therapies: Developing Precision CRISPR Editing for Finnish Founder Pathogenic Variants
In-depth epidemiological, molecular, and genetic characterization of nodular lymphocyte-predominant Hodgkin´s lymphoma and T-cell/histiocyte rich large B-cell lymphoma FUND: Cancer and Cell Based Cancer Research
Pään ja kaulan kolmiulotteinen mallintaminen – kuvantaminen, leikkauspreparaatti ja histopatologia
Modeling disorders of hypothalamic-pituitary-gonadal axis
Germline variants in severe hematological diseases and their effect on hematopoietic stem cell transplantation outcomes and comorbidities FUND: Cancer and Cell Based Cancer Research
Oral Health in Cryptogenic Ischemic Stroke
Transcription stress-induced remodeling of RNA polymerase II-complex affects chromatin-accessibility FUND: Urological research
The impact of screen time and parental linguistic support on the language development of children aged 2.5 to 4.2 years
A fast and automated identification of disease-specific malignant and healthy cells using single-cell transcriptomics FUND: Cancer and Cell Based Cancer Research
Lipidomics and its link to genetics, cardio-metabolic disease risk, and lifestyle factors FUND: Cardiovascular
A genetic engineering strategy to control cell proliferation for cell therapies.
"Harnessing pro-apoptotic actions of metformin in novel combination therapeutic approaches for MYC-high breast cancer" FUND: Cancer and Cell Based Cancer Research
TARGETING SOX18 PIONEERING ACTIVITY IN ONCOGENIC HERPESVIRUS TUMORIGENESIS FUND: Cancer and Cell Based Cancer Research
Sex differences in the human plasma proteome
The relationship between the external and internal exposome linking to adolescent mental health
O-GlcNAcylation directly controls RNA polymerase II (RNA Pol II) activity FUND: Urological research
Optimizing Personalized Drug Combinations for Acute Myeloid Leukemia Subtypes Using Multi-Omics Data and Machine Learning
4000 €
Characterisation of the role of TrkB in glioblastoma neuroplasticity FUND: Brain Cancer
Immune responses and evasion strategies of Borrelia spirochetes in neuroborreliosis. FUND: Borrelia reserch
Characteristics of above 65-years-olds with type 1 diabetes in the Finnish Diabetic Nephropathy Study
Group B streptococcus virulence factors and their interaction with the complement system
Mechanisms of Aβ binding to microbial surfaces FUND: Borrelia research
Bile acids as mediators of metabolic improvement in adipose tissue after weight loss through bariatric surgery
Impact of pre-eclampsia and hypertensive disorders of pregnancy on the risk of cardiovascular disease and all-cause mortality in women with type 1 diabetes FUND: Cadiovascular
Immune landscape and CLEVER-1 expression in hepatoblastoma FUND: Cancer and Cell Based Cancer Research
Humanizing mice for the study of schizophrenia patient-derived microglia-like cells
2023 apurahansaajat
50 000 €
Deciphering genomic determinants of immunity in tumour organoid models at single-cell resolution FUND: Cancer and Cell Based Cancer Research
6 000 €
Characterizing the Tumor Microenvironment in Diffuse Large B-cell Lymphoma FUND: Cancer and Cell Based Cancer Research
Simple devices for single cell trapping and droplet digital PCR
Myelin plasticity in resilience and susceptibility to psychosocial stress-induced anxiety
Large-scale genome-wide studies of migraine FUND: Neurological and Cerebrovascular Disorder
FUNCTIONAL AND ANTIGEN-SPECIFIC CHARACTERIZATION OF IMMUNE CELLS AT THE SINGLE-CELL LEVEL REVEALS CONVERGENCE OF ADAPTIVE AND INNATE IMMUNITY
Germline variants in severe hematological diseases and their effect on hematopoietic stem cell transplantation outcomes and comorbidities FUND: Cancer and Cell Based Cancer Research
Prognostic factors of lower extremity artery disease – from diagnostic strategies and medication to histologic plaque characteristics. FUND: Cardiovascular
Accelerating Cancer Research through Interactive Visualization Techniques
A genetic engineering strategy to control cell proliferation
Novel Epidemiological Aspects of Type 1 Diabetes in Children
Tumoral microenvironment and genomic biomarkers for precision oncology in ovarian cancer
Julius Development of hiPSC-Derived Models for the Study of Charcot-Marie-Tooth Disease FUND: Neurological and Cerebrovascular Disorder
Molecular mechanisms of coronary vasculature development and relationship to physiological and pathological hypertrophy FUND: Cardiovascular
4 000 €
Primary adrenal insufficiency: Epidemiological aspects and associating features in APECED
O-GlcNAc transferase epistatically regulates gene expression in response to transcriptional stress FUND: Urological research
Aivovaltimonpullistuman puhkemiseen vaikuttavat tulehdukselliset tekijät: seerumin amyloidi A, imusuonet ja lymfosyytit tulehdusvasteen säätelyssä. FUND: Neurological and Cerebrovascular Disorder
Evidence Synthesis in Orthopaedics – Guiding Clinical Practice in Shoulder Surgery
Rannekanavaoireyhtymä: ilmaantuvuus, riskitekijät sekä taloudelliset vaikutukset suomalaisessa väestössä FUND: Marketta Helenius Fund for Health Sciences
Oxidative stress influencing the tumor-immune interplay in triple-negative breast cancer
Munuaissiirron luovuttajan ja potilaan geneettisen vaihtelevuuden, sekä siirtoparien välisten geneettisten erojen vaikutus siirteen komplikaatioihin suomalaisilla munuaissiirtopareilla.
Understanding neural crest stemness in development and disease FUND: Cancer and Cell Based Cancer Research
Geneettiset tekijät ei-alkoholiperäisen rasvamaksataudin patogeneesissä—vaikutukset maksan lipidimetaboliaan ja histopatologiaan
Psychometric Validation of (Short) Warwick-Edinburgh Mental Well-Being Scale in Finnish Context – Mental Well-Being before, during and after COVID-19 FUND: Marketta Helenius Fund for Health Sciences
SOX18 TRANSCRIPTION FACTOR AS AN ATTRACTIVE MOLECULAR TARGET FOR KAPOSI’S SARCOMA, A VIRAL CANCER FUND: Cancer and Cell Based Cancer Research
Representation learning in large-scale epidemiological studies
4 000 €
Antimicrobial effects of amyloid β may explain neuroinflammation and degeneration FUND: Borrelia research
Tumor educated platelets in pediatric brain cancer diagnostics
Yleisimpien perinnöllisten sairauksien geenivirheiden kantajuus suomalaisessa geeniperimässä & Perinnöllisyyslääketieteen ammattilaisten asenteet laajennettua kantajuusseulontaa kohtaan
Aivojen valkean aineen sairauden kliinisen kulun tutkimus käyttäen päälle puettavia mittareita FUND: Neurological and Cerebrovascular Disorder
Uutta tietoa rintasyövän perinnöllisyydestä
Nielurisojen osapoistoleikkauksen vaikuttavuus lasten kuorsauksen ja unihäiriön hoidossa
Lasten epilepsiakirurgia Suomessa: pitkäaikaistulokset ja komplikaatiot
2022 apurahansaajat
40 000 €
TWIST1 regulates smooth muscle cell phenotype as a mechanim of coronary artery disease risk
6000 €
Environmental effects on the epigenome, gene regulation, and embryonic development
Immune responses and evasion strategies of Borrelia spirochetes in neuroborreliosis
Clinical applicability of highly multiplex t-CycIF imaging from clinical high-grade serous ovarian tumor samples in assessing the tumor-immune microenvironment
Diabeteksen solukorvaushoitojen turvallisuuden parantaminen sekä synnynnäisen hyperinsulinismin lääkehoidon kehitys kantasoluperäisten saarekkeiden avulla
MicroRNAs as regulators of lineage commitment in human embryos.
Enhancing NK cell therapy anti-tumour efficacy for treatment of immunosuppressive solid tumours with an engineered oncolytic adenovirus coding for a human vIL-2 cytokine
Biomarkers of the gut fungal and bacterial compositions in inflammatory bowel disease
Predicting personalized cancer drug combinations by integrating drug screening and single-cell lineage tracing data
4000 €
MOLECULAR PROFILING OF UTERINE LEIOMYOMAS
New MYC-targeting Synthetic Lethal Strategies in Breast Cancer
Changes in subarachnoid hemorrhage mortality in the Finnish population – a national register-based study of 10,000 cases over the last 20 years.
Immune responses and evasion strategies of Borrelia spirochetes in neuroborreliosis
Loss of CDK12 triggers epigenetic reprogramming of prostate cancer cells to stem-cell like state
Mutant RFX6 disturbs pancreatic progenitor identity and its haploinsufficiency impairs beta-cell functionality predisposing to Type-2 diabetes
Development of a clinically relevant gene-editing strategy to correct the Finnish-founder pathogenic mutations causing CADASIL, Familial Hypercholesterolemia, and ASL.
COVID-19: diagnostic sensitivity and immunological consequences
Molecular genetic background of uterine leiomyomas and adenomyomas
Molecular Background of Uterine Leiomyomas and Leiomyosarcomas
Identification of personalized drug combinations for cancer patients
Verkkopohjaisen painonhallintaintervention vaikutus psyykkiseen hyvinvointiin ja koettuun elämänlaatuun
Tollin kaltaiset reseptorit sekä seerumin sytokiinit haiman duktaalisen adenokarsinooman prognostisina ja erotusdiagnostisina työkaluina
Modern aMMP-8 Poc/chairside diagnostic and treatment modalities in periodontitis and peri-implantitis
Role of the ventral tegmental area somatostatin-expressing neurons in the brain circuits and behaviour.
Extra-adrenal synthesis of aldosterone in the murine gut, regulation and relevance
Dysregulated germinal center reaction in the pathogenesis of neurological autoimmune diseases
Blood RNA adenosine methylation as a biomarker for ischemic heart disease
The development of work arrangements work ability and health in later careers
Antibodies against Streptococcus pneumoniae have a protective role against atherosclerosis by neutralizing Pro atherogenic HDL particles
The genetics of arterial stiffness in individuals with type 1 diabetes
Genetic Architecture of Intellectual Disability in Northern Finland
Repetitive transcranial magnetic stimulation targeting secondary somatosensory cortex in the treatment of complex regional pain syndrome
Ihomelanooman metastaattinen vartijasolmuke
ACCTAR: Accurately Targeting Cancer Vulnerabilities with AI-boosted Integration of Multi-source Perturbational Data
4000 €
Immunological profiling of natural killer cells in discontinuation of tyrosine kinase inhibitor therapy in chronic myeloid leukemia patients
Identifying Markers for Diagnosing the Overtraining Syndrome
Neurotoxic effects of MDMA in amygdala
“Chronic total occlusion percutaneous coronary intervention (CTO-PCI). Impact and prognosis.” – First thesis in Finland about chronic total occlusions.
Treatment of hallux rigidus (HARD trial): study protocol of a RCT-trial of arthrodesis versus watchful waiting in the treatment of a painful osteoarthritic first metatarsophalangeal joint
SARS-CoV-2 Variants of Concern Serology and Characterization of Novel SARS-CoV-2 Neutralizing Binder Molecules
Integrative Genomics of Insulin Resistance and Cardiometabolic Risk
2021 apurahansaajat
50 000 €
The role of physical activity in cognitive aging – longitudinal twin study on the relationships between physical activity, cognitive functioning and biomarkers of Alzheimer’s disease
6000 €
A nationwide artificial intelligence assessment of cardiometabolic risk
MelanoMAP: Single-clonotype roadmap of the evolution of T cell response during checkpoint therapies in metastatic melanoma patients
Genome wide CRISPR-Cas9 knockout screening with NK cell lymphoma/leukemia.
Cancer cell-microenvironment communication in high grade serous ovarian cancer
Humeral shaft fractures in adults – Effectiveness of surgery versus functional bracing: FISH (Finnish Shaft of the Humerus) Trial
Mechanisms of cellular cholesterol storage and removal: focus on NPC1 regulation
4000 €
Mutational landscape shaped by replication errors and DNA mismatch repair – from intestinal stem cell to mature epithelial cell
Stromal Lkb1 role in gastrointestinal epithelial regeneration and tumorigenesis
Modeling neurodegeneration in spinal muscular atrophy Jokela type using patient-specific and gene edited motor neurons
Towards Curative Therapy of Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia
Prediction of drug-combination toxicity based on single-cell RNA-seq expression atlases and combinatorial target and structural information
Understanding the role of Piezo1 mediated mechanosensation in epidermal homeostasis
Molecular genetics of rimmed vacuolar myopathies and deregulation of the cellular stress response
Mutation in MADD affects hormone expression in pituitary gonadotropes and pancreatic β-cells
The consequences of increased mitochondrial DNA replication: From premature ageing to neonatal heart failure
Adiponectin receptor as a target for the prevention of diabetic kidney disease
Lymphocyte somatic mutations and immune cell landscape in acquired aplastic anemia
Evidence Synthesis in Orthopaedics – Guiding Clinical Practice in Shoulder Surgery
Circulating Tumor DNA and Survival Associated Mutations in Diffuse Large B-cell Lymphoma
Identification of genetic risk factors in canine and human dilated cardiomyopathy and ventricular arrhythmia
Migraine with aura – susceptibility variants
Genetic susceptibility to molecularly unexplained colorectal cancer and polyposis
Ihmisen kudoksissa persistoivat DNA-virukset
Identification of new genetic causes for neuromuscular diseases and their modeling using stem cell derived motor neurons
Molecular mechanisms of coronary vasculature development and relationship to physiological and pathological hypertrophy
The role and regulation of DNA methylation in cancer
Primaaristen immuunipuutosten patogeeneesi geeni- ja molekyylitasolla
Haimatulehdus – ehkäisy, diagnosointi, ennuste ja vaikuttava hoito
Personalized drug combination recommendation for cancer patients by integrating drug screening and single-cell technologies
4000 €
Changes in subarachnoid hemorrhage mortality in the Finnish population – a national register-based study of 10,000 cases over the last 20 years.
Role of delay and antibiotics on PERForation rate while waiting appendECTomy (PERFECT): a protocol for a randomized non-inferiority trial
Pathophysiology and treatment of mitochondrial muscle disease
Investigation into protective variants modulating the penetrance of the C9ORF72 expansion in Finnish ALS
Circulating tumor DNA (ctDNA) – a promising biomarker for gastrointestinal cancers
Chronic subdural hematoma: reducing recurrences and epidemiology